Research Interest: Stem Cells, Cancer, Immune Therapy, Regenerative Medicine.
Dr. Monther AlAlwan is a scientist at the Stem Cell and Tissue Re-engineering Program (SCTRP), King Faisal Specialist Hospital and Research Centre, as well as an Associate professor at Alfaisal University, Riyadh Saudi Arabia. He holds M.Sc. and Ph.D. in Immunology from Dalhousie University (Halifax, Canada). Dr. AlAlwan conducted a 3-years postdoctoral fellowship studying signaling in immune cells at the University of Manitoba, Canada. During his graduate studies and postdoctoral fellowship, Dr. AlAlwan made substantial contribution in the immunology field, particularly his groundbreaking discovery that highlighted the significance of the dendritic cells in the immunological synapse. After joining the SCTRP in 2007, he shifted gear to study cancer, where he identified novel mechanisms that regulate cancer metastasis and chemoresistance. Currently, he is actively involved in dissecting the molecular pathways that regulate the function of cancer stem cells and how this related to chemoresistance and metastasis. Dr. AlAlwan is an author in 20 peer-reviewed publications, has delivered several invited lectures and is a regular reviewer for various international journals.
Research Interest: As Is Clear From The Biography, Shigetaka Asano Accomplisheddistinguished
Performance In Research Based On Medical Needs By Full Of Enthusiasm With
State-Of-The-Art New Technology, Such As 1. Verification Of Existence Of Rabbit
Neutrophil Cell Membrane Knack+-Atpase, 2. Discovery Of Laterarity Of Mouse
Intestinal Mucous Membrane Proteins, 3. Finding Of Human Tumor Cell Mediated By
Granulocyte Colony-Stimulating Factor (G-CSF; Bioactive Substance To Stimulate
Differentiation, Proliferation And Functional Activity Of Neutrophil), 4. Analysis
Of Human G-CSF Activity, 5. Succeeding In Incubation Of Human Tumor
Infiltrating T Lymphocyte Colony, 6. Discovery Of Allogenicimmunosuppression Of
Placenta Decidual Cells, 7. Differentiation Induction Of Mesenchymalstem Cell,
8. Cloning Of G-Csfcdna And Development Of Recombinant Human Native G-CSF (Lenograstim)
As The 1st Generation Biomedicine, 9. Constitution Of International Clinical
Guideline For Transplantation Of Bone-Marrow And Cord Blood, And Construction
Of Public Bank Of Bone-Marrow And Cord Blood, 10. Non-Clinical Study Of Human
Granulocyte Colony-Stimulating Factor (GM-CSF; Bioactive Substance To Stimulate
Differentiation, Proliferation And Functional Activity Of Macrophage Besides
Neutrophil)Immunogene Therapy And Execution Of The Phase Iia Clinical Study,
11. Non-Clinical Study Of Utilizing Maxizyme For Immunogene Therapy Of Myeloid
Leukemia Cell, 12. Acquisition And Molecular Analysis Of Leukemia Stem Cell
Like Property By Stochastic Adhesion Of In Vitro Human Myelogenous Leukemic
Cell Line Cell And Stromal Cell, 13. Pathological Analysis Of Mesenchymalstem
Cell(Parental Cell Of Range Of Cell Consist Ofstroma) Differentiation And
Proliferation In Translin(Substance Found As Molecule To Bind Fusion Gene Of
Lymphatic Leukemia) Knockout Mouse.
Research Interest: Focuses on Aging-Related Diseases and Stem Cell
Research Interest: Cancer Stem Cells, Ocular Stem Cells
Research Interest: Cell Reprogramming and Induced Pluripotent Stem
Cells, Stem Cells and Neural Tissue Engineering, Mammalian Inner Ear
Development and Hair Cell Regeneration.
Research Interest: Clinical Nephrology, Metabolic Syndrome, Hypertension, Inflammation
Research Interest: Hematopoietic Stem Cell Transplanting, Cell Therapy
and Everything in the Field of Publication and Education.
Research Interest: Embryonic Stem Cells, Pluripotency, Induced Pluripotent
Cells, Differentiation, Endoderm, Beta Cell, Diabetes, Obesity, Adipose Tissue,
Brown Fat, Endothelium, Oxidative Stress, Nitric Oxide, Peroxynitrite, Superoxide,
Two Major Projects are Currently Underway in the Laboratory.
A Cell Reprogramming Technique Has Been Used to Convert Heterogeneous Malignant Breast Cancer Cells into Induced Pluripotent Stem Cells Using Sox2/Oct4/Nanog Proteins. Dr. Wu’s Laboratory is Clarifying these Induced Pluripotent Stem Cells for their Differentiation Potential and Oncogenic Properties, and Try to Develop a Novel Cell Converting Therapy for Malignant Breast Cancer Treatment.
Metastasis, the Spread of Cancer Cells from the Primary Tumor To Distant Organs, Is The Most Dreadful Development Of Breast Cancer, As Well As Other Neoplastic Diseases. Although Metastasis Contributes To Over 90% Of Human Cancer Mortality, The Molecular Mechanism Of This Process Remains Largely Unknown. Dr. Wu’s Laboratory Is In The Process Of Identifying Molecular Signatures Involved In Breast Cancer Metastasis Using Integrative Genetic, Epigenetic And Proteomic Approach, As Well As Animal Models And Clinical Specimens.
Research Interest: Fate Decisions of Embryonic Stem Cell, Induced
Pluripotent Stem Cell (ESC/Ips): Pluripotency and Direct Lineage Specification to
the Three Germ Layers.
Research Interest: Cancer Biology, Cell Biology, Breast Cancer, Cancer
Prevention, Anti-Cancer Drug Development, Cancer Metastasis, Transcription
Factors, Kinase, Glucose Metabolism.
Research Interest: Clinical Pharmacology, Gastroenterology, Pharmaceutical Development, Drug Development, Colorectal Cancer, Inflammatory Bowel Disease, Ulcerative Colitis, Crohn's Disease
Research Interest: Actually Works
as Young Researcher in Projects Regarding Genomics, Proteomics and Inflammatory
Aspects of Human Breast Cancer and Chronic Diseases.
Years She Extended her Initial Research Interests on Endothelial Progenitor
Cell (EPC) Biology and their Potential use in Regenerative Medicine.
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Published On: December 31, 2016 | Pages: 001 - 005Abstract View Full Article View
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Published On: December 29, 2016 | Pages: 017 - 024Abstract View Full Article View
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