Research Interest: Natural Product Chemistry, Medicinal Chemistry, Chemical Biolgoy

Research Interest:  "Targeted drug delivery; Chemical functionalization of nanoparticles; Chemical composition-biological behavior relationship of nanoparticles; Biomaterials for immunotherapy; Nanomedicine; Pharmaceutical Nanotechnology; Nanovaccines; Immunotoxicity of nanoparticles; Surface biofunctionalization of the nanoparticles with antibodies and peptides; Cell-nanoparticle interactions

"

Research Interest: Asymmetric synthesis, total synthesis of natural products, multi-component reactions, heterocyclic synthesis and green chemistry

Research Interest: Isolation and structural elucidation of biologically active metabolites from natural sources (Plants, Bacteria, Marine and Fungi). Phytochemical characterization of plant extracts used in traditional medicine, their pharmacological evaluation, and the isolation and identification of their active constituents

Research Interest: Phenolic content and antioxydant activity of medicinal plants, Anti-inflammatory, analgesic and antipyretic activities of medicinal plants, Mutagenic and anticancer effects of medicinal plants. NF-κB pathway inhibition, Antileishmanial and antitrypanosomal activities of medicinal plants, Antioxidant, anticancer, mutagenic, Anti-inflammatory, Analgesic, Antipyretic, Antiparasitic, Polyphenols, Flavonoïds, medicinal plants 

Research Interest: Medicinal Chemistry.

Research Interest: Topics in chemical quality control in pharmacy practice; Application of different analytical techniques for the determination of pharmaceuticals in the presence of their degradation product(s) including; Different spectrophotometric methods such as colorimetry, derivative and derivative-ratio spectrophotometry. Different chromatographic methods such as TLC-densitometry, Preparative TLC, Two-dimensional TLC, GC and HPLC. Monitoring of the degradation profile of the pharmaceuticals and kinetic studies. Synthesis of the degradation product(s) of the selected drugs and structure elucidation.Chemometric methods, such as CLS, PCR and PLS.

Research Interest: Isolation and structural elucidation of biologically active metabolites from natural sources (Plants and Fungi); Marine natural products chemistry and biology; Phytochemical characterization of plant extracts used in traditional medicine, their pharmacological evaluation, and the isolation and identification of their active constituents.

Research Interest: Organic chemistry, molecular imaging and bioorganic chemistry, including organofluorine chemistry, asymmetric synthesis and catalysis, and the relevant mechanistic studies using various physical organic chemistry tools,   molecular imaging, PET/Fluorescence/MRI multi modality imaging, inhibited tumor growth suppresion, and nanoparticle assembled drug delivery

Christoforos G. Kokotos is an Assistant Professor of Organic Chemistry at the Department of Chemistry, National and Kapodistrian University of Athens, Greece, with undergraduate studies at the University of Athens, PhD studies at the University of Bristol, UK (Prof. Varinder Aggarwal) and post-doctoral studies at Princeton University, USA (Prof. David W. C. MacMillan). His research interests focus on the development of novel asymmetric organocatalytic methodologies, green and sustainable organocatalytic oxidations, Photocatalysis, their application in the synthesis of pharmaceuticals, compounds of biological importance and natural products and the study of the mechanisms of organic transformations employing modern techniques, like HRMS. He is co-author of 71 peer-reviewed papers, 4 book chapters, 2 patents, >40 presentations in conferences. He is the recipient of prestigious awards, like the Hildergard-Zervas Award, Academy of Athens (2016 and 2018), JSP fellowship for the Burgenstock Conference (2016), Young Investigators Workshop (3 times representing Greece, 2014, 2017 and 2018) and ACS Young Academic Investigators Award (2014, representing Europe).

Research Interest: Organic Chemistry, Food Chemistry, Green Chemistry

Grants: (1) Research Funding Scheme Post-doc, “PEPCAT-Novel Organocatalysts Based on Peptides and Amino Acids and their Application in Asymmetric Organic Transformations”, General Secretariat for Research and Development (2012-2015, 150.000 €).

(2) Organocatalysis – ORCA, Cost Action CM0905 funded by the intergovernmental framework for European Cooperation in Science and technology (2011-2014), Management Committee Substitute and co-Organizer of the third ORCA meeting in Athens, 2012. Action Chair: Prof. P. Pihko, University of Jyvskyl, Finland.

(3) Research Proposal Funding Scheme, John Latsis Foundation “PhotoOrganocatalysis: Development of new environmentally-friendly methods for the synthesis of compounds for the pharmaceutical and chemical industry” (2015, 12.000€).

(4) C-H Activation in Organic Synthesis – CHAOS, Cost Action CM15106 funded by the intergovernmental framework for European Cooperation in Science and technology (2016-2020), Management Committee Substitute. Action Chair: Prof. M. Schnurch, Technical University of Vienna, Austria.

(5) Fellowship for PhD programme, Ms Errika Voutyritsa, State Scholarships Foundation (IKY), 2016.

(6) Fellowship for PhD programme, Ms Ierasia Triandafillidi, Hellenic Foundation for Research and Innovation (ELIDEK), 2017.

(7) Fellowship for PhD programme, Mr Nikolaos Nikitas, State Scholarships Foundation, 2018.

(8) European Network on Pseudomyxoma Peritonei – PMP, Cost Action CA17101 funded by the intergovernmental framework for European Cooperation in Science and technology (2019-2023), Management Committee Member. Action Chair: Prof. Kjersti Flatmark, Oslo University Hospital, Norway.

(9) Chemobrionics, Cost Action CA17120 funded by the intergovernmental framework for European Cooperation in Science and technology (2019-2023), Management Committee Member. Action Chair: Prof. Julyan Cartwright, CSIC Granada, Spain.

(10) Fellowship for PhD programme, Ms Nikoleta Spiliopoulou, Hellenic Foundation for Research and Innovation (ELIDEK), 2019.

(11) Research Funding Scheme Teams of Young Investigators, “Green and Sustainable Organocatalysis: Novel Epoxidation reactions and their application in Chemical Industry”, General Secretariat for Research and Development (2019-2021, 50.000 €).

List of Publications:1.    “Photoorganocatalytic Synthesis of Acetals from Aldehydes” N. F. Nikitas, I. Triandafillidi and C. G. Kokotos*, Green Chem., 2019, 21, 669-674. (citations: 0) (Impact factor: 8.59)

2.    “Enantioselective Organocatalytic Enamine C-H Oxidation/Diels-Alder Reaction” Z. Dzambaski, D.-I. Tzaras, S. Lee, C. G. Kokotos and B. P. Bondzic*, Adv. Synth. Catal., 2019, 361, 1792-1797. (citations: 0) (Impact factor: 5.12)

3.    “Photocatalytic Atom Transfer Radical Addition to Olefins utilizing Novel Photocatalysts” E. Voutyritsa, I. Triandafillidi, N. V. Tzouras, N. F. Nikitas, E. K. Pefkianakis, G. C. Vougioukalakis and C. G. Kokotos*, Molecules, 2019, 24, 1644-1653. (citations: 0) (Impact factor: 3.09)

4.    “Photocatalytic Synthesis of γ-Lactones from Alkenes: High-Resolution Mass Spectrometry as a Tool to Study Photoredox Reactions” I. Triandafillidi, M. G. Kokotou and C. G. Kokotos*, Org. Lett., 2018, 20, 36-39. (citations: 8) (Impact factor: 6.49)

5.    “Organocatalytic Synthesis of Oxazolines and Dihydrooxazines from Allyl-Amides: Bypassing the Inherent Regioselectivity of the Cyclization” A. Theodorou, I. Triandafillidi and C. G. Kokotos*, Adv. Synth. Catal., 2018, 360, 951-957. (citations: 0) (Impact factor: 5.12)

6.    “Green Photo-Organocatalytic C−H Activation of Aldehydes: Selective Hydroacylation of Electron-Deficient Alkenes” G. N. Papadopoulos, E. Voutyritsa, N. Kaplaneris and C. G. Kokotos*, Chem. Eur. J., 2018, 24, 1726-1731. (citations: 2) (Impact factor: 5.16)

7.    “Expanding the Scope of Photocatalysis: Atom Transfer Radical Addition of Bromoacetonitrile to Aliphatic Olefins” E. Voutyritsa, I. Triandafillidi and C. G. Kokotos*, ChemCatChem, 2018, 10, 2466-2470. (citations: 1) (Impact factor: 4.67)

8.    “Photoorganocatalysis, Small Organic Molecules and Light in the Service of Organic Synthesis: the Awakening of a Sleeping Giant” I. K. Sideri, E. Voutyritsa and C. G. Kokotos*, Org. Biomol. Chem., 2018, 16, 4596-4614. Invited Review. (citations: 7) (Impact factor: 3.56)

9.    “Combining Οrganocatalysis with Photoorganocatalysis: Photocatalytic Hydroacylation of Asymmetric Organocatalytic Michael Addition Products” A. Schiza, N. Spiliopoulou,  A. Shahu and C. G. Kokotos*, New J. Chem., 2018, 42, 18844-18849. (citations: 7) (Impact factor: 3.28)

10.    “Proline Dipeptides Containing Fluorine Moieties as Organocatalysts for the Asymmetric Aldol Reaction” A. Ahmetlli, N. Spiliopoulou, A. Magi-Oikonomopoulou, D.-T. Gerokonstantis, P. Moutevelis-Minakakis* and C. G. Kokotos*, Tetrahedron, 2018, 74, 5987-5995. (citations: 0) (Impact factor: 2.65)

11.    “Green Organocatalytic Oxidative Methods using Activated Ketones” I. Triandafillidi, D. I. Tzaras, and C. G. Kokotos*, ChemCatChem, 2018, 10, 2521-2535. (citations: 1) (Impact factor: 4.67)

12.    “Combining Prolinamides with 2-Pyrrolidinone: Novel Organocatalysts for the Asymmetric Aldol Reaction” I. Vlasserou, M. Sfetsa, D. T. Gerokonstantis, C. G. Kokotos* and P. Moutevelis-Minakakis*, Tetrahedron, 2018, 74, 2338-2349. (citations: 3) (Impact factor: 2.65)

13.    “Photoorganocatalytic Atom Transfer Radical Addition of Bromoacetonitrile to Aliphatic Olefins” E. Voutyritsa, N. F. Nikitas, M. K. Apostolopoulou, A. D. D. Gerogiannopoulou and C. G. Kokotos*, Synthesis, 2018, 50, 3395-3401. Invited Contribution for Special Issue: Photoredox Methods and their Strategic Applications in Synthesis (citations: 0) (Impact factor: 2.72).

14.    “Green Photoorganocatalytic Synthesis of Phenols from Arylboronic Acids” I. K. Sideri, E. Voutyritsa and C. G. Kokotos*, Synlett, 2018, 29, 1324-1328. Invited Contribution for Special Issue: 9th EuCheMS Organic Division Young Investigator Workshop (citations: 3) (Impact factor: 2.37)

15.    “Organocatalytic Synthesis of Lactones by the Oxidation of Alkenoic Acids” I. Triandafillidi, M. Raftopoulou, A. Savvidou, and C. G. Kokotos*, ChemCatChem, 2017, 9, 4120-4124. (citations: 3) (Impact factor: 4.67)

16.    “Photoorganocatalytic Synthesis of Lactones via a Selective C–H Activation–alkylation of Alcohols” N. Kaplaneris, A. Bisticha, G. N. Papadopoulos, D. Limnios and C. G. Kokotos*, Green Chem., 2017, 19, 4451-4456. (citations: 11) (Impact factor: 8.59)

17.    “Visible-Light-Mediated Catalytic Hydroacylation of Dialkyl Azodicarboxylates by Graphite Flakes” G. S. Koutoulogenis, M. G. Kokotou, E. Voutyritsa, D. Limnios, C. G. Kokotos*, Org Lett., 2017, 19, 1760-1763. (citations: 11) (Impact factor: 6.49)

18.    “Organocatalytic Oxidation of Substituted Anilines to Azoxybenzenes and Nitro Compounds: Mechanistic Studies Excluding the Involvement of a Dioxirane Intermediate” E. Voutyritsa, A. Theodorou, M. G. Kokotou and C. G. Kokotos*, Green Chem., 2017, 1291-1298. (citations: 14) (Impact factor: 8.59) 2017 Green Chemistry Hot

19.    “Green Organocatalytic Synthesis of Indolines and Pyrrolidines from Alkenes” A. Theodorou and C. G. Kokotos*, Adv. Synth. Catal., 2017, 359, 1577-1581. (citations: 9) (Impact factor: 5.12)

20.    “Green Organocatalytic Synthesis of Isoxazolines via a One-Pot Oxidation of Allyloximes” I. Triandafillidi and C. G. Kokotos*, Org. Lett., 2017, 19, 106-109. (citations: 17) (Impact factor: 6.49)

21.    “Photoinitiated Thiol-Ene “Click” Reaction: An Organocatalytic Alternative” D. Limnios and C. G. Kokotos*, Adv. Synth. Catal., 2017, 19, 1291-1298. (citations: 20) (Impact factor: 5.12)

22.    “Organocatalytic Synthesis of Polysubstituted Tetrahydrofurans from Alkenes” A. Theodorou and C. G. Kokotos*, Green Chem., 2017, 19, 670-674. (citations: 11) (Impact factor: 8.59)

23.    “Green Organocatalytic Dihydroxylation of Alkenes” A. Theodorou, I. Triandafillidi and C. G. Kokotos*, Eur. J. Org. Chem., 2017, 11, 1502-1509. (citations: 5) (Impact factor: 2.88)

24.    “Green Organocatalytic Synthesis of Dihydrobenzofurans by Oxidation-Cyclization of Allylphenols” I. Triandafillidi, I. K. Sideri, D. I. Tzaras, N. Spiliopoulou and C. G. Kokotos*, Synthesis, 2017, 49, 4254-4260. Invited Contribution for Special Issue: Modern Strategies in Cyclization Reactions (citations: 2) (Impact factor: 2.77).

25.    “Green Organocatalytic Oxidation of Sulfides to Sulfoxides and Sulfones” E. Voutyritsa, I. Triandafillidi and C. G. Kokotos*, Synthesis, 2017, 49, 917-924. Invited Contribution for Burgenstock Conference (citations: 13) (Impact factor: 2.77).

26.    “Enantioselective Organocatalytic Synthesis of 2-Oxopiperazines from Aldehydes: Identification of the Elusive Epoxy Lactone Intermediate” N. Kaplaneris, C. Spyropoulos, M. G. Kokotou and C. G. Kokotos*, Org. Lett., 2016, 18, 5800-5803. (citations: 5) (Impact factor: 6.49)

27.    “One-pot Amide Bond Formation from Aldehydes and Amines via a Photoorganocatalytic Activation of Aldehydes” G. N. Papadopoulos and C. G. Kokotos*, J. Org. Chem., 2016, 81, 7023-7028. (citations: 17) (Impact factor: 4.81)

28.    “Photoorganocatalytic One-pot Synthesis of Hydroxamic Acids from Aldehydes” G. N. Papadopoulos and C. G. Kokotos*, Chem. Eur. J., 2016, 22, 6964-6967. (citations: 27) (Impact factor: 5.12)

29.    “Green Organocatalytic α-Hydroxylation of Ketones” E. Voutyritsa, A. Theodorou and C. G. Kokotos*, Org. Biomol. Chem., 2016, 14, 5708-5713. Invited Article for the Special Thematic issue “New Talent in Organic and Medicinal Chemistry”. (citations: 10) (Impact factor: 3.56)

30.    “(Thio)urea-mediated Synthesis of Functionalized Six-membered Rings with Multiple Chiral Centers” G. Koutoulogenis, N. Kaplaneris and C. G. Kokotos*, Beilstein J. Org. Chem., 2016, 12, 462-495. Invited Article for the Special issue “Multifunctional Organocatalysis”. (citations: 19) (Impact factor: 2.76)

31.    “4-Fluoro and 4-Hydroxy Pyrrolidine-thioxotetrahydropyrimidinones: Organocatalysts for Green Asymmetric Transformations in Brine” N. Kaplaneris, G. Koutoulogenis, M. Raftopoulou and C. G. Kokotos*, J. Org. Chem., 2015, 80, 5464-6473. (citations: 21) (Impact factor: 4.81)

32.    “tert-Butyl Esters of Peptides as Organocatalysts for the Asymmetric Aldol Reaction” A. Bisticha, I. Triandafillidi and C. G. Kokotos*, Tetrahedron: Asymmetry, 2015, 26, 102-108. (citations: 15) (Impact factor: 2.13)

33.    “One-pot Synthesis of O-Allylhydroxylamines through the Organocatalytic Oxidation of Tertiary Allylic Amines followed by a [2,3]-Meisenheimer Rearrangement” A. Theodorou, D. Limnios and C. G. Kokotos*, Chem. Eur. J., 2015, 21, 5238-5241. (citations: 20) (Impact factor: 5.12)

34.    “tert-Butyl Ester or Benzylamide of the Dipeptide Pro-Gly as Organocatalysts for the Asymmetric Aldol Reaction” I. Triandafillidi, A. Bisticha, E. Voutyritsa, G. Galiatsatou and C. G. Kokotos*, Tetrahedron, 2015, 71, 932-940. (citations: 20) (Impact factor: 2.65)

35.    “Conjugating Proline Derivatives onto Multi-walled Carbon Nanotubes: Preparation, Characterization and Catalytic Activity in Water” D. D. Chronopoulos, C. G. Kokotos, M. Tsakos, N. Karousis, G. Kokotos and N. Tagmatarchis, Mat. Lett., 2015, 157, 212-214. (citations: 5) (Impact factor: 2.69)

36.    “Functionalized Multi-walled Carbon Nanotubes in an Aldol Reactions” D. D. Chronopoulos, C. G. Kokotos, N. Karousis, G. Kokotos* and N. Tagmatarchis*, Nanoscale, 2015, 7, 2750-2757. (citations: 8) (Impact factor: 7.23)

37.    “Organocatalytic Oxidation Reactions” D. Limnios and C. G. Kokotos*, Current Organocatalysis, 2015, 2, 171-190. (citations: 3) (Impact factor: -)

38.    “Fullerene-proline Hybrids: Synthesis, Characterization and Organocatalytic Properties in Aldol Reactions” D. D. Chronopoulos, M. Tsakos, N. Karousis, C. G. Kokotos* and N. Tagmatarchis*, Mat. Lett., 2014, 137, 343-346. (citations: 11) (Impact factor: 2.69)

39.    “Photoorganocatalytic Hydroacylation of Dialkyl Azodicarboxylates by utilizing Activated Ketones as Photocatalysts” G. N. Papadopoulos, D. Limnios and C. G. Kokotos*, Chem. Eur. J., 2014, 20, 13811-13814. (citations: 24) (Impact factor: 5.12)

40.    “2,2,2-Trifluoroacetophenone: An Organocatalyst for an Environmentally Friendly Epoxidation of Alkenes” D. Limnios and C. G. Kokotos*, J. Org. Chem., 2014, 79, 4270-4276. (citations: 37). Feature Article, ACS Editors Choice Article, Top Read Article for the last 12 months, Highlighted at TCI catalogue for 2,2,2-trifluoroacetophenone. (Impact factor: 4.81)

41.    “One-pot Synthesis of Ureas from Boc-Protected Amines” C. Spyropoulos and C. G. Kokotos*, J. Org. Chem., 2014, 79, 4477-4483. (citations: 30) (Impact factor: 4.81)

42.    “2,2,2-Trifluoroacetophenone as an Organocatalyst for the Oxidation of Tertiary Amines and Azines to N-Oxides” D. Limnios and C. G. Kokotos*, Chem. Eur. J., 2014, 20, 559-563. (citations: 34) (Impact factor: 5.12)

43.    “tert-Butyl Esters of Tripeptides based on Pro-Phe as Organocatalysts for the Asymmetric Aldol Reaction in Aqueous or Organic Medium” A. Psarra, C. G. Kokotos* and P. Moutevelis-Minakakis*, Tetrahedron, 2014, 70, 608-615. (citations: 29) (Impact factor: 2.65)

44.    “Primary and Secondary Amine-(thio)ureas and Squaramides and their Applications in Asymmetric Organocatalysis” M. Tsakos and C. G. Kokotos*, Tetrahedron, 2013, 69, 10199-10222. (citations: 91) (Impact factor: 2.65)

45.    “Organocatalytic Oxidation of Organosilanes to Silanols” D. Limnios and C. G. Kokotos*, ACS Catalysis, 2013, 3, 2239-2243. (citations: 33) (Impact factor: 11.38)

46.    “β-tert-Butyl Aspartate as an Organocatalyst for the Asymmetric α-Amination of α,α-Disubstituted Aldehydes” A. Theodorou, G. N. Papadopoulos and C. G. Kokotos*, Tetrahedron, 2013, 69, 5438-5443. (citations: 23) (Impact factor: 2.65)

47.    “An Asymmetric Michael Addition of α,α-Disubstituted Aldehydes to Maleimides leading to a One-pot Enantioselective Synthesis of Lactones Catalyzed by Amino Acids” C. G. Kokotos*, Org. Lett., 2013, 15, 2406-2409. (citations: 49) (Impact factor: 6.49)

48.    “Microwave-Assisted Organocatalytic Cross-Aldol Condensation of Aldehydes” D. Limnios and C. G. Kokotos*, RSC Adv., 2013, 3, 4496-4499. (citations: 16) (Impact factor: 2.94)

49.    “Organocatalytic Asymmetric Domino Michael-Henry Reaction for the Synthesis of Substituted Bicyclo[3.2.1]octan-2-ones” M. Tsakos, M. R. J. Elsegood and C. G. Kokotos*, Chem. Commun., 2013, 49, 2219-2221. (citations: 45) (Impact factor: 6.29)

50.    “Novel Prolinamide-Ureas as Organocatalysts for the Asymmetric Aldol Reaction” P. Revelou, C. G. Kokotos* and P. Moutevelis-Minakakis*, Tetrahedron, 2012, 68, 8732-8738. (citations: 28) (Impact factor: 2.65)

51.    “Pyrrolidine-thioxotetrahydropyrimidinone as an Efficient Organocatalyst for the Enantioselective Michael Addition of Cyclic Ketones to Nitrodienes” M. Tsakos. M. Trifonidou and C. G. Kokotos*, Tetrahedron, 2012, 68, 8630-8635. (citations: 13) (Impact factor: 2.65)

52.    “A Tripeptide-like Prolinamide-Thiourea as an Aldol Reaction Catalyst” S. Fotaras, C. G. Kokotos and G. Kokotos, Org. Biomol. Chem., 2012, 10, 5613-5619. (citations: 35) (Impact factor: 3.56) 

53.    “Primary Amine-Thioureas with Improved Catalytic Properties for “Difficult” Michael Reactions. Efficient Organocatalytic Syntheses of (S)-, (R)-Baclofen and (S)-Phenibut” M. Tsakos, C. G. Kokotos and G. Kokotos, Adv. Synth. Catal., 2012, 354, 740-746. (citations: 47) (Impact factor: 5.12)

54.    “Enantioselective Organocatalytic α-Alkylation of Ketones Utilising SN-1 Type Reaction of Alcohols” M. Trifonidou and C. G. Kokotos*, Eur. J. Org. Chem., 2012, 1563-1568. (citations: 33) (Impact factor: 2.88)

55.    “Construction of Tertiary Alcohols Bearing Perfluoroalkyl Chains Catalyzed by Prolinamide-Thioureas” C. G. Kokotos*, J. Org. Chem., 2012, 77, 1131-1135. (citations: 46) (Impact factor: 4.81)

56.    “Organocatalytic “Difficult” Michael Reaction of Ketones with Nitrodienes Utilising Primary Amine-Thioureas Based on di-tert-Butyl Esters of Aspartic Acid” M. Tsakos and C. G. Kokotos*, Eur. J. Org. Chem., 2012, 576-580. (citations: 24) (Impact factor: 2.88)

57.    “Novel Pyrrolidine-thiohydantoins/thioxotetrahydropyrimidinones as Highly Effective Catalysts for the Asymmetric Michael Addition” C. G. Kokotos, D. Limnios, D. Triggidou, M. Trifonidou and G. Kokotos, Org. Biom. Chem., 2011, 9, 3386-3395. (citations: 37) (Impact factor: 3.56) 

58.    “Prolinamides bearing Thiourea Groups as Catalysts for Asymmetric Aldol Reactions” S. Fotaras, C. G. Kokotos, E. Tsandi and G. Kokotos, Eur. J. Org. Chem., 2011, 1310-1317. (citations: 50) (Impact factor: 2.88)

59.    “Potent and Selective Fluoroketone Inhibitors of Group VIA Calcium-independent Phospholipase A2” G. Kokotos, Y.-H. Hsu, J. Burke, C. Baskakis, C. G. Kokotos, V. Magrioti and E. A. Dennis, J. Med. Chem., 2010, 53, 3602-3610. (citations: 53) (Impact factor: 6.26)

60.    “Interactions at the Bilayer Interface and Receptor Site Induced by the Novel Synthetic Pyrrolidinone Analog MMK3” C. Fotakis, S. Gega, E. Siapi, C. Potamitis, K. Viras, P. Moutevelis-Minakakis, C. G. Kokotos, S. Durdagi, S. Golic Grdadolnik, B. Sartori, M. Rappolt and T. Mavromoustakos, Biochim. Biophys. Acta Biomembranes, 2010, 1798, 422-432. (citations: 23) (Impact factor: 3.44) 

61.    “Bacillus subtilis Esterase (BS2) and its Double Mutant have Different Selectivity in the Removal of Carboxyl Protecting Groups” E. Barbayianni, C. G. Kokotos, S. Bartsch, C. Drakou, U. Bornscheuer and G. Kokotos, Adv. Synth. Catal., 2009, 351, 2325-2332. (citations: 10) (Impact factor: 5.12) 

62.    “Primary Amine-thioureas based on tert-Butyl Esters of Natural Amino Acids as Organocatalysts for the Michael Reaction” C. G. Kokotos and G. Kokotos, Adv. Synth. Catal., 2009, 351, 1355-1362. (citations: 71) (Impact factor: 5.12) 

63.    “Sulfonamides of Homoproline and Dipeptides as Organocatalysts for Michael and Aldol Reactions” E. Tsandi, C. G. Kokotos, S. Kousidou, V. Ragoussis and G. Kokotos, Tetrahedron, 2009, 65, 1444-1449. (citations: 50) (Impact factor: 2.65) 

64.    “Synthesis of Medicinally Interesting Polyfluoro Ketones via Perfluoroalkyl Lithium Reagents” C. G. Kokotos, C. Baskakis and G. Kokotos, J. Org. Chem., 2008, 73, 8623-8626. (citations: 24) (Impact factor: 4.81)

65.    “Sulfur Ylide Mediated Three-component Aziridination and Epoxidation Reactions using Vinyl Sulfonium Salts” C. G. Kokotos, E. M. McGarrigle and V. K. Aggarwal, Synlett, 2008, 2191-2195, highlighted in Synfacts, 2008, 11, 1142. (citations: 24) (Impact factor: 2.37)

66.    “Aminals as Substrates for Sulfur Ylides: A Synthesis of Functionalised Aziridines and N-Heterocycles” C. G. Kokotos and V. K. Aggarwal, Org. Lett., 2007, 9, 2099-2102. (citations: 39) (Impact factor: 6.49)

67.    “A Practical Synthesis of a [2.2.1] Bicyclic Chiral Sulfide for Asymmetric Transformations” V. K. Aggarwal, G. Fang, C. G. Kokotos, J. Richardson and M. G. Unthank, Tetrahedron, 2006, 62, 11297-11303. (citations: 26) (Impact factor: 2.65)  

68.    “Hemi-aminals as Substrates for Sulfur Ylides: Direct Asymmetric Syntheses of Functionalised Pyrrolidines and Piperidines” C. G. Kokotos and V. K. Aggarwal, Chem. Commun., 2006, 2156-2158. (citations: 42) (Impact factor: 6.29)   

69.    “Synthesis, Binding Studies, and in vivo Biological Evaluation of Novel non-Peptide Antihypertensive Analogues” T. Mavromoustakos, P. Moutevelis-Minakakis, C. G. Kokotos, P. Kontogianni, A. Politi, P. Zoumpoulakis, J. Findlay, A. Cox, A. Balmforth, A. Zoga and E. Iliodromitis, Bioorg. Med. Chem., 2006, 14, 4353-4360. (citations: 21) (Impact factor: 2.79)

70.    “Systemic and Intrathecal Effects of a Novel Series of Phospholipase A2 Inhibitors on Hyperalgesia and Spinal PGE2 Release” T. L. Yaksh, G. Kokotos, C. I. Svensson, D. Stephens, C. G. Kokotos, B. Fitzsimmons, D. Hadjipavlou-Litina, X. Y. Hua and E. A. Dennis, J. Pharmacol. Exp. Ther., 2006, 316, 466-475. (citations: 56) (Impact factor: 3.87)

71.    “Synthesis and Activity of 2-Oxoamides containing Long Chain β-Amino Acids” V. Constantinou-Kokotou, A. Peristeraki, C. G. Kokotos, D. A. Six and E. A. Dennis, J. Peptide Sci., 2005, 11, 431-435. (citations: 18) (Impact factor: 1.55)

Research Interest: Ion selective electrodes techniques,Voltammetric techniques,Spectrophotometric techniques,Chemometric techniques for simultaneous determination of mixtures.

Research Interest: Antioxidant Activity, Antioxidants, Ethnobotany, Compound Isolation, Bioactivity, Free Radical Scavengers, DPPH, Biotechnology, Essential Oils, Antioxidant Assays, Flavonoids, Phenol, Phytochemicals, Natural Product Chemistry, Chromatography, Natural Product Isolation, Anthocyanins, Extraction, Phytochemical Analysis, Ethnopharmacology, Phytochemical Purification, Herbal Medicine, Biological Activities, Soxhlet Extraction, Natural Product Pharmacology, Antibacterial Activity, Nutraceuticals, Natural Product Drug Discovery, Ethnomedicine, Ethnopharmacy, Chemotaxonomy, Herbal Drug Development, Evaluation of Cytotoxicity, Medicinal and Pharmaceutical Chemistry, Traditional Medicine, Pharmacological Screening, Natural Compound, Fatty acid composition, Fatty acid analysis.Pharmacology, Biochemistry, Natural Products, Chromatography, Asphodeline.