• Postdoctoral Research Fellow, University of Botswana, Gaborone, August 2021-Present
• Senior Consultant (Covid-19), Botswana Harvard AIDS Partnership, Gaborone, March 2020-Present
• Mentor/Advisory (Undergraduate Students), University of Botswana, Gaborone, January 2017-Present
• Research Laboratory Scientist, Botswana-UPenn Partnership, Gaborone, February 2015- July 2021
• Intern, UCSI University, Kuala Lumpur, January 2013- July 2013
• Research Laboratory Assistant, UCSI University, Kuala Lumpur, October 2012- December 2013
Research Interest: Pharmacokinetics/genomics in HIV and Malaria, HIV infection on the distribution of human papillomavirus genotypes, Pathogenesis of persistent cervicovaginal infections of oncogenic HPV genotypes, Host epigenetic changes associated with cervical cancer progression, Clinical trials work to improve meningitis outcomes in Botswana, Examining the utility of novel diagnostics to improve outcomes in HIV-associated meningitis patients, Molecular Surveillance of Plasmodium falciparum Drug Resistance Markers and Plasmodium falciparum multi drug resistance gene 1 mutations in symptomatic patients.
Grants: Identification of differential expression of host genes in cervical cancer, U54-, U54, Co-PI and Graduate Student, 05/24/17-05/28/21 and Human papillomavirus infection in HIV-infected and HIV-uninfected women from Botswana and Kenya: HPV genetic variation by phylogenetic type. Project Leader, 2019 to 2021.
Research Interest:Nanomedicine, Controlled/Targeted Drug Delivery,
Toxicology, Pharmacology, Cellular Interaction, Nanofilms and Microcapsules,
Biomimetic, Microbiology, Immunology.
Research Interest: Innovative Clinical Therapeutic Agents
To Improve Cure Rates In Patients With Brain And Spinal Tumors, With Particular
Focus On Immunotherapeutics As Well As Molecular-Targeting Agents,
Anti-Angiogenic Reagents, Cytotoxins And Other Biologically-Based Therapies.
Research Interest:Basic Biology/Physiology Of Salivary
Glands, Prevention Of Radiation-Induced Salivary Gland Damage, Gene Transfer To
Salivary Glands, Viral Vector Modification And Improving Viral Vectors For Gene
Transfer.
Research Interest: My Research Focus on Design Universal and
Live Attenuated Influenza Vaccine by using Novel Methods, and Testingthese New
Generation Vaccine Candidates in Humanized Mice and Ferrets. As Well, We would like
to explore the Mechanism of Cross-Protection induced by live Attenuated
Influenza against seasonal and Pandemic Influenza Viruses. Our Results
Suggested That Activation of T cell Is Crucial for the cross Protection
Stimulated By vaccination With Live Attenuated Influenza Vaccine. In Future
Research, We Will Focus on B Cell Development Stimulated by Vaccination with
Live Attenuated Influenza vaccine. To Facilitate The Development Of More
Effective Vaccines, We Are Also Researching: The Effect Of Current Vaccination
Programs On The Epidemiological Changes Of Respiratory Pathogens (Strain
Replacement And Antigenic Variation); How People Respond To Infections Or
Vaccinations At The Cellular And Molecular Levels (B Cell, T Cell, And Gene expression
Levels) identification of New Protective Antigens Through Genomic And Proteomic
Approaches.
Research Interest: He focused on developing novel
adjuvants and vaccine delivery systems for prophylactic vaccination along with
rational design of new vaccine formulations for Novartis discovery projects.
Research Interest: Structural determination of
protein-DNA, Solid: X-ray, Solution: 2D & 3D NMR, and Gas: Mass
Spectrometry, interactions and their pathways, stability, dynamics, and
function.
Research Interest: Cytokine based Immunotherapies to
treat lymphopenia, Clinical biomarkers in psychological disorders, Effects of
Inflammation on hematopoiesis.
Research Interest: Pre-treatment staging of lung cancer
using integrated CT-PET and comparing its accuracy with conventional CT scan
and pathological staging. Prospective study on the incidence of post-needle biopsy
pneumothorax looking at the relationship
between early lung function testing
manoeuvre, after full radiological expansion of lung and recurrence of
pneumothorax. UP-FRONT FDG CT-PET study - Prospective study to look at whether
performing Up-Front FDG CT-PET in the pre-treatment evaluation of lung cancer
reduces time interval and the number of invasive procedures for definitive
diagnosis.
Research Interest: Her project here focused on the
development of a novel therapeutics for the treatment of immune and
inflammatory skin diseases such as psoriasis using a skin epidermal Langerhans
cell model.
Research Interest: HTA and to new communication
strategies with people about vaccination, especially in consideration of the
rising phenomena of anti-vaccination movements.
Research Interest: Allergy test in clinical diagnosis,
Immunotherapy and in vitro cell assay, Anti-inflammatory properties of natural
compounds, Allergy and vaccination, Basophil activation tests.
Istituto Zooprofilattico Sperimentale dell Umbria e delle Marche
Italy
s.petrini@izsum.it
JVI
Biography: Full Researcher involved the National Reference Laboratory (NRL) for Pestivirus and Asfivirus and the employed the Laboratory of Virology at the Istituto
Zooprofilattico Sperimentale Umbria-Marche, Perugia, Italy. He is also a member
of National
Reference Centre for Alternative Methods, Wellness and Care of Laboratory
Animals at the Istituto Zooprofilattico Sperimentale Lombardia and
Emilia-Romagna, Brescia
Research Interest: Conduct several molecular biology and
genomic assays including Sequencing, Cloning, RT-PCR, Southern blot, Northern
blot, and Immunostaining.
Research Interest: Molecular biology of viruses, the
interactions of viruses with host cells, the pathogenesis of viral diseases,
the post-translational modification of viral proteins, and mechanisms of host
defense. The research works are designed to increase fundamental knowledge as
well as to facilitate the development of new approaches to control of viral
infection.
Research Interest: The structure of sulfated
polysaccharides extracts from seaweeds. The activity of sulfated
polysaccharides such as nephrophaty and Parkinsion Disease. The comprehensive
utilization of seaweeds especially Saccharina japonica.
Research Interest: The keywords of my research interest:
Reproductive immunology, Thymic stromal lymphopoietin, The costimulatory
signal, Trophoblast, Gamma-delta T cell, CD4+CD25bright regulatory T cell,
Pregnancy, Miscarriage, The maternal-fetal immune.
Research Interest: Molecular mechanisms of immune evasion
of EBV and HSV-1. Molecular mechanisms of EBV and HSV-1 infection and its
interaction with the host. Mechanisms of pathogenesis of EBV and HSV-1
infection.
Published Papers:
1. Representative papers published after work
1) Li ML, Chen T, Wang P, Zou XM, Xu Z, Wang YF, Chen DX, Peng T, Cai MS(*). Characterization of the nucleocytoplasmic transport mechanisms of Epstein-Barr virus BFLF2. Cellular Physiology and Biochemistry, 2018, Accept. (SCI, IF=5.5)
2) Cai MS, Liao ZM, Chen T, Wang P, Zou XM, Wang YF, Xu Z, Jiang S, Huang JL, Chen DX, Peng T, Hong GD, Li ML(*). Characterization of the subcellular localization of Epstein-Barr virus encoded proteins in live cells. Oncotarget, 2017, 8(41), 70006-70034. (SCI, IF=5.168)
3) Cai MS, Li ML, Wang KZ, Wang S, Lu Q, Yan JH, Mossman KL, Lin RT, Zheng CF(*). The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway. Plos One, 2013, 8(1), e54586. (SCI, IF=3.534) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054586
4) Cai MS, Deng SX, Li ML(*). Comparison of the immune responses in BALB/c Mice following immunization with DNA-based and live attenuated vaccines delivered via different routes. Vaccine, 2013, 31(9),1353-1356. (SCI, IF=3.485) https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(12)01308-4
5) Cai MS, Jiang S, Zeng ZC, Li XW, Mo CC, Yang YJ, Chen CK, Xie PP, Bian Y, Wang JL, Huang JL, Chen DX, Peng T, Li ML(*). Probing the nuclear import signal and nuclear transport molecular determinants of PRV ICP22. Cell & Bioscience, 2016, 6: 3. (SCI, IF=3.294) https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-016-0069-7
6) Cai MS, Jiang S, Li XW, Zeng ZC, Li ML(*). Characterization of the nuclear import mechanisms of HSV-1 UL31. Biological Chemistry. 2016, 397(6): 555-561. (SCI, IF=3.273) https://www.degruyter.com/doi/10.1515/hsz-2015-0299
7) Cai MS, Huang ZB, Liao ZM, Chen T, Wang P, Jiang S, Chen DX, Peng T, Bian Y, Hong GD, Yang H, Zeng ZC, Li XW, Li ML(*). Characterization of the subcellular localization and nuclear import molecular mechanisms of herpes simplex virus 1 UL2. Biological Chemistry. 2017, 398(4): 509-517. (SCI, IF=3.273) https://www.degruyter.com/doi/10.1515/hsz-2016-0268
8) Cai MS, Li ML, Zheng CF(*). Herpesviral infection and Toll-like receptor 2. Protein & Cell, 2012, 3(8), 590-601. (SCI, IF=3.22)
https://dx.doi.org/10.1007/s13238-012-2059-9
9) Li ML, Jiang S, Mo CC, Wang JL, Huang JL, Zeng ZC, Li XW, Chen CK, Yang YJ, Peng T, Cai MS(*). Identification of molecular determinants for the nuclear import of pseudorabies virus UL31. Archives of Biochemistry and Biophysics, 2015, 587, 12-7. (SCI, IF=2.807) https://linkinghub.elsevier.com/retrieve/pii/S0003-9861(15)30075-8
10) Li ML, Jiang S, Wang JL, Mo CC, Zeng ZC, Yang YJ, Chen CK, Li XW, Cui W, Huang JL, Peng T, Cai MS(*). Characterization of the nuclear import and export signals of pseudorabies virus UL31. Archives of Virology, 2015, 160, 2591-2594. (SCI, IF=2.255) https://link.springer.com/article/10.1007/s00705-015-2527-7
11) Cai MS, Chen DX, Zeng ZC, Yang H, Jiang S, Li XW, Mai JY, Peng T, Li ML*. Characterization of the nuclear import signal of herpes simplex virus 1 UL31. Archives of Virology, 2016, 161(9):2379-2385. (SCI, IF=2.058) https://dx.doi.org/10.1007/s00705-016-2910-z
12) Li ML, Cui W, Mo CC, Wang JL, Zhao ZY, Cai MS(*). Cloning, expression, purification, antiserum preparation and its characteristics of the truncated UL6 protein of herpes simplex virus 1. Molecular Biology Reports, 2014, 41(9), 5997-6002. (SCI, IF=2.024) https://dx.doi.org/10.1007/s11033-014-3477-y
2. Representative papers published at the time of Ph.D. candidate 13) Cai MS, Wang S, Long J, Zheng CF(*). Probing of the nuclear import and export signals and subcellular transport mechanism of varicella-zoster virus tegument protein open reading frame 10. Medical Microbiology and Immunology, 2012, 201(1), 103-111. (SCI, IF=3.545) https://link.springer.com/article/10.1007/s00430-011-0211-4
14) Cai MS, Wang S, Xing JJ, Zheng CF(*). Characterization of the nuclear import and export signals, and subcellular transport mechanism of varicella-zoster virus ORF9. Journal of General Virology, 2011, 92(Pt 3), 621-626. (SCI, IF=3.363) http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.027029-0#tab2
15) Li ML, Wang S, Cai MS, Zheng CF(*). Identification of nuclear and nucleolar localization signals of PRV early protein UL54 reveals that its nuclear targeting is required for efficient production of virus. Journal of virology, 2011, 85, 10239–10251. (SCI, IF=5.402) http://jvi.asm.org/content/85/19/10239.long
16) Wang L, Li ML, Cai MS, Xing JJ, Wang S, Zheng CF(*). A PY-nuclear localization signal is required for nuclear accumulation of HCMV UL79 protein. Medical Microbiology and Immunology, 2012, 201(3),381-387. (SCI, IF=3.545)
17) Li ML, Wang S, Cai MS, Guo H, Zheng CF(*). Characterization of molecular determinants for nucleocytoplasmic shuttling of PRV UL54. Virology, 2011, 417, 385-417. (SCI, IF=3.351) https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(11)00268-6
3. Representative papers published at the time of M.Sc. candidate 18) Cai MS, Cheng AC(*), Wang MS, Chen WP, Zhang X, Zheng SX, Pu Y, Lou KP, Zhang Y, Sun L, Wang LL, Zhu DK, Luo QH, Chen XY. Characterization of the duck plague virus UL35 gene. Intervirology, 2010, 53(6), 408-416. (SCI, IF=1.756) https://www.karger.com/?DOI=10.1159/000317291
19) Cai MS, Cheng AC (*), Wang MS, Zhao LC, Zhu DK, Luo QH, Liu F, Chen XY. His6-tagged UL35 protein of duck plague virus: expression, purification, and production of polyclonal antibody. Intervirology, 2009, 52(3),141-151. (SCI, IF=1.106) https://www.karger.com/?DOI=10.1159/000221833
20) Cai MS, Cheng AC (*), Wang MS, Zhao LC, Zhu DK, Luo QH, Liu F, Chen XY. Characterization of synonymous codon usage bias in the duck plague virus UL35 gene. Intervirology, 2009, 52(5), 266-278. (SCI, IF=1.106) https://www.karger.com/Article/Abstract/231992
Research Interest: Nanoparticles, liposomes,
solid lipid naonparticles, and anhydrous reverse micelles, drug/vaccine
carriers, freeze-drying of pharmaceutics, design, carrying out and analysis of
in vivo tests, separation and purification of chemicals, extraction and
analysis of therapeutic.
Research Interest: Diagnosis of fungal infections;
Therapy of mycoses; Pathogenesis of fungal infection; Antifungal drug
resistance; Fungal infection animal model; Genomics in medical mycology;
Candida mucosal immunity; Infectious dermatosis; genodermatoses.
Research Interest: Infectious disease, vaccine,
immunology, focus in infectious diseases, epidemiology, microbiology, vaccine
development and efficacy.
Research Interest: They relate to functions within
Ministry of research (head of mission of the Life Sciences), CNRS (medical
advisor for the life sciences), INSERM, ANRS, advisor for clinical Research,
and for International Affairs APHP/public hospitals of Paris.
Research Interest: Structure-to-function relationships of
microbial lectins Structural study of multivalent protein-carbohydrate
interactions Analysis of differential glycosylation and bacterial infection
pathology during metabolic imbalance Structure-based design of anti-bacterial
and anti-fungal drugs.
Research Interest: Bacteria of the genus Staphylococcus,
in particular the species S. aureus and virulence factors produced by this
species. In the so far carried out research, the results of which were
published in several peer-reviewed journals I analyzed:
1.The influence of
leucocytotoxic and superantygenic virulence factors produced by S. aureus
strains isolated from milk of cows with mastitis on the cytokine production and
gene expression in bovine leukocyte cultures in vitro;
2. the impact of staphylococcal exotoxins on the process of phagocytosis in
vitro;
3. the efficacy of treatment of mastitis by staphylococcal autovaccine;
4. the profile of resistance to methicillin of coagulase-negative staphylococci
isolated from animals;
5. the profile of the genes encoding superantigens in S. aureus and S. xylosus
isolates collected from cows;
6. the possibility of transfer of genes encoding superantigens between
staphylococci occurring in the same mammary gland;
7. genetic relatedness of staphylococci isolated within a herd of animals;
8. the biological activity of staphylococcal exosecretions against leukocytes
in vitro;
9. the impact of staphylococcal virulence factors on the morphology of
leukocytes in vitro.
I also analyzed and published in the GenBank several new 16S rRNA gene
sequences of bacteria representing different species of staphylococci,
identified by PCR-RFLP analysis of gap gene. Furthermore, as a contributor I
published in the GenBank the 16S rRNA gene sequences of bacterial isolates,
which were unidentified based on the polymorphism of gap gene, of which at
least two isolates represent new species or subspecies of the staphylococci.
The second direction of my research concerns the use of magnetic fields, in
particular the rotating magnetic field to modify the functional parameters and
pathogenicity potential of different species of microorganisms. At the present,
I’m analyzing the influence of magnetic field on metabolic processes in
microorganisms, both at the cellular and molecular level. As a continuation of
my first research mainstream microorganism used in these studies is primarily
S. aureus.
Research Interest: Currently, his studies focus on the
two major directions. The first one is to study the innate receptor TLR and NLR
ligands as adjuvant for CTL epitope-based vaccines to treat cancer and the
adjuvant effect on the modulation of immune responses will be studied.
Research Interest: Develop treatment
modality/Process/Biomarkers for the soldiers working in the extreme conditions.
Based on these stressors, different models of stress like hypobaric hypoxia,
cold, Isolation (Antarctica) and viral infection are being used to overcome
from the stress induced maladies.
Research Interest: Complement system, Immunoassays,
Proteomics, Biomarkers in diseases, Vaccines, T regulatory cells and diseases,
Immunology of leprosy and tuberculosis.
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