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    Analysis of the mechanism underlying the effects of cyclophosphamide against triple-negative breast cancer by an integrative bioinformatics approach

    DOI Logo 10.17352/ijpsdr.000035

    Published On: December 24, 2021 | Pages: 006 - 015

    Author(s): Maojing Wang, Wenwen Li, Ding Li and Zhiwu Han*
    Patients with Triple-Negative Breast Cancer (TNBC), a highly heterogeneous and invasive subtype of breast cancer, do not benefit from hormonal therapy or trastuzumab; therefore, chemotherapy is considered the only option. We explored the effect of the chemotherapeutic drug cyclophosphamide (Cytoxan; Cy) on TNBC by an integrated bioinformatics approach. Methods: Pharm ... CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat
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    The use of pentoxifylline in male reproduction abnormalities

    DOI Logo 10.17352/ijpsdr.000034

    Published On: August 10, 2021 | Pages: 003 - 005

    Author(s): Aamir Jalal Al-Mosawi*
    Pentoxifylline a derivative of methylxanthine and nonspecific inhibitor of the phosphodiesterase with vasodilatory properties and rheological properties on blood that made it useful in the treatment of intermittent claudication. Pentoxifylline also has an immunomodulatory effect which inhibits inflammatory cytokines including tumor necrosis factor-alpha. The aim of th ... CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat
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    Is it possible to perform molecular hybridization between acetaminophen and nitric oxide donor molecule?

    DOI Logo 10.17352/ijpsdr.000033

    Published On: March 09, 2021 | Pages: 001 - 002

    Author(s): João Gabriel Gouvêa-Silva, Leonardo Ribeiro Bernardo, Ygor Jessé Ramos* and Antônio José Calixto de Souza
    Paracetamol (Acetaminophen) belongs to the class of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), having an analgesic, antipyretic and mild anti-inflammatory action due to a weak inhibitory action on cyclooxygenase isoenzymes, COX-1 and COX-2. These isoenzymes are responsible for the synthesis of prostanoids that have several physiological effects, such as: vasodila ... CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat
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    A cross sectional study of alcohol consumption and risk factors

    DOI Logo 10.17352/ijpsdr.000032

    Published On: September 23, 2020 | Pages: 034 - 037

    Author(s): R Dinesh Kumar, J Kalaiselvi and Siva S*
    Introduction : Alcohol consumption is an important contributor to the global burden of different disease such as stroke, sleep apnea, pancreatitis, diabetes mellitus, CAD and so on. Urban populations are having greater risk of getting the alcohol induced disease. Objective: A cross sectional study of alcohol consumption associated with risk of different disease. To i ... CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat
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    Developing analytical parameters and evaluation of thermo fisher urinary creatinine enzymatic method to implement in open system chemistry analyzers

    DOI Logo 10.17352/ijpsdr.000031

    Published On: September 16, 2020 | Pages: 030 - 033

    Author(s): Ashraf Mina*, Leah McNeice, Shanmugam Banukumar and Santiago Vazquez
    Creatinine assay is used mainly to monitor kidney function and for sample validity when testing for drugs of abuse. Creatinine alkaline picrate method based on Jaffe’s reaction calls for extra cleaning procedures to minimize interference from picric acid and sodium hydroxide. Thermo Fisher enzymatic method is more sensitive and specific when compared to alkaline picra ... CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat
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