Research Interest: Tumours Role of transcription factors for angiogenesis, tumour invasion and metastasis Interaction of tumour cells and cells of the tumour stroma Translational research Molecular targeting therapy Biochemical, immunological and pharmacological assays for characterization of the efficacy of different therapeutic agents Tumour immunology Immune evasion mechanism of tumour cells.

Research Interest: Focused on molecularly targeted therapy and genetic abnormalities in cancer (mostly in lung cancer), immunooncology, immunology and genetic of obstructive sleep apnea, asthma, COPD and sarcoidosis

Research Interest: My research interest involves finding innovative gene therapy solutions for human diseases. At Bellicum, Pharmaceuticals, I have played a leading role in the discovery and pre-clinical development of the CIDeCAR and Go-CART product portfolios. Prior to Bellicum, I was a trainee at Baylor College of Medicine where I developed a novel platform for delivery of erythropoietin to treat anemia associated with chronic kidney disease and evaluated the safety of the piggyBac gene delivery system for gene and cell the rapy. I have extensive research experience in immunotherapy of leukemias and solid tumors, adoptive transfer of T cells, T cell biology, tumor infiltrating lymphocytes, immune receptors biology, antigen processing and recognition, antibody therapy, tumor immunology, viral and non-viral vectors, and gene therapy of monogeneic disorders. I have comprehensive knowledge of molecular biology research techniques including genetic engineering, vector design, cloning, transfection platforms,

cytometry, biomarker development and validation and synthetic DNA construction 

Research Interest: Radiopharmaceutical development that involves radiolabeled agents and their evaluations both in vitro and in vivo. These agents are for disease detection, life process tracing, or tumor radiotherapy.

Research Interest: Anti-Cancer, Apoptosis, Blebbing, Caspases, Cell Cycle, Cell Signaling, Cancer, DNA Fragmentation, Drug Discovery, Flow Cytometer, Intrinsic and extrinsic apoptosis pathway, Laser Confocal Microscope, Mitochondrial Depolarization and Necrosis.

Research Interest: Molecular mechanisms  and  signaling  pathways  underlying  cancer  progressi on,  metastasis and chem resistance

Research Interest: Cancer Genetics, Apoptosis, Oncogenes, Tumor Suppressor Genes, Mechanisms of Anti-Cancer Drug Resistance.

Research Interest: Melanoma, kidney cancer , immunotherapy with ipilimumab, nivolumab, interleukin-2 and other agents. 

Research Interest: Molecular biology, cytogenetics, genotoxicity, micronucleus, cytome assay, mutagenicity tests, gene expression, human cancer, pituitary adenomas, obesity.

Research Interest: These cancers express unique tumor-specific or -associated antigens to which my lab directs T cell immune responses via DNA, RNA, protein or peptide based vaccines.  Vaccine components are delivered in their native form, by dendritic cells, by recombinant Adeno Associated Virus.  This clinically translational research is backed up by pre-clinical and basic research in both normal and transgenic animal models and in laboratory studies on patient material. Results from the pre-clinical studies have led to a variety of clinical trials for which I am the immunological coordinator. 

Research Interest: Malignant transformation, including DNA Repair mechanisms, roles of Cytoskeleton in signal transduction, Developmental processes

Eugenia Yiannakopoulou: Surgeon; Endocrine Surgeon; Breast Surgeon; Pharmacologist. Current position:  Faculty in the Department of Biomedical Scineces, Faculty of Health and Caring Professions, ,University of West Attica, Athens,  Greece;  Director of her own private medical practice.  Titles: Ptychio of medicine; MSc Minimally Invasive Surgery; MSc Medical Biology; MSc Biostatistics; PhD Pharmacology; University Diploma in Breast Diseases University of Strasbourg, France; University Diploma of Laparoscopic Surgery University of Strasbourg, France. University Diploma of Endocrine Surgery University Pierre et Marrie Currie Paris, University Diploma in Targeted Biotherapeis of Inflammatory and Autoimmune Diseases, University of Montpellier, University Diploma in Inflammatory Bowel Diseases Medical School University Pierre et Marie Currie Paris.   Postdoctoral research in Pharmacology. She speaks English, German, Italian, French, Russian, Spanish, Portugues, Dutch. Member of the Research Committee of EAES. Research and Editorial Activity: Author of 60 publications, 641 citations, reviewer of international journals, Grant Reviewer, Congress Abstract Reviewer, Executive Editor of International Journal of Immunotherapy and Cancer Research, member of Editorial boards of International Journals.

Research Interest: Minimally invasive surgery, endocrine surgery, breast surgery, surgical stress, surgical pharmacology, laparoscopic surgery, robotic surgery, surgical anatomy.

List of Publication:

[1] Yiannakopoulou E Systematic review of the effect of oxidative stress in minimally invasive surgery in comparison with conventional surgery. Msc Thesis for the Msc “Minimally invasive surgery, robotic surgery and telesurgery” Athens 2009

[2] Yiannakopoulou E Investigation of the role of salicylates in preconditioning Final Report for Postdoctoral Research (IKY Scholarship 15109/07.10.2005) Athens 2007

[3] Yiannakopoulou E Quality of diagnosis and treatment of arterial hypertension in Greece PhD Thesis Medical School University of Athens, Athens 2003 (3 Citations)

[4] Yiannakopoulou E Meta-analysis of Randomized Clinical  Trials for the evaluation of safety of coxibs Msc Thesis for the Msc Biostatistics Medical School and Department of Mathematics Univesity of Athens, Athens 2004

[5] Yiannakopoulou E Cellular mechanisms of adaptation in oxidative stress and in heat shock in Saccharomyces cerevisiae: the effect of antioxidants Msc Thesis for the Msc Medical Biology Medical School and Department of Biology University of Athens.

BOOK CHAPTERS:

1. Eugenia Ch Yiannakopoulou "BREAST CANCER PHARMACOGENOMICS: CLINICAL IMPLICATIONS FOR PERSONALIZED MEDICINE" for “Omics Aproaches for Breast Cancer” Editor Barth D published by Springer

2. Eugenia Ch Yiannakopoulou " BREAST CANCER THERAPY- CLASSICAL THERAPY, DRUG TARGETS, AND TARGETED THERAPY" for “Omics Aproaches for Breast Cancer” Editor Barth D published by Springer

3. Eugenia Ch Yiannakopoulou , Emmanuel O SALAWU,  Debmalya Barh. In silico models of disease In Animal Biotechnology: Models in discovery and Translation: A Verma and A Singh,  Edition Elsevier 1st Edition

4. Eugenia Yiannakopoulou “Pharmacogenomics” in OMICS:Advances and applications Barth D, Raja R, Zambare V ( (IN press) Publisher Taylor Francis

5.P.O. Michael, E. Yiannakopoulou, “Trauma of heart and pericardium” in “Trauma of Thorax” P. Michael Litsas Edition Athens 2002, pp 236-297 (in Greek).

6. Τh.Diamantis, A.Kyritsis, D.Koronarchis, A.Kyriakopoulos, M.Kastanakis, E.Yiannakopoulou. “Laparoscopic treatment for gastroesophageal reflux disease. Five year experience”  in “Laparoscopic and other invasive techniques in the beginning of 21st century” 2000  Ch Tsigris, Th. Diamantis Litsas Edition Athens (in Greek)

Book Translations in Greek: Three English Medical Books of Pharmacology and Physiology and three German Medical Books of Clinical  Pharmacology and Therapeutics.

FULL PUBLICATIONS IN INTERNATIONAL PEER REVIEWED JOURNALS

1.     Yiannakopoulou E. Minimally Invasive Parathyroidectomy in the Treatment of Patients with MEN I. J Surg Tech Proced. 2018; 2(2): 1019

2.    Yiannakopoulou E.  Interplay  between  asthma  and  gastroesophageal  reflux  disease:  A  controversial  issue. Arch Asthma Allergy  Immunol. 2018; 2: 006-007. https://doi.org/10.29328/journal.aaai.1001011

3.    Yiannakopoulou E Immunomodulatory effect of physical exercise: from immunosuppression to immune protection Virology and Immunology Journal 2018

4.    Francis N, Kazaryan AM, Pietrabissa A, Goitein D, Yiannakopoulou E, Agresta F, Khatkov I, Schulze S, Arulampalam T, Tomulescu V, Kim YW, Targarona EM, Zaninotto G A research agenda for the European Association for Endoscopic Surgeons (EAES). Surg Endosc. 2017 May;31(5):2042-2049

5.    Eugenia Yiannakopoulou The role of minimally invasive surgery in neuroendocrine pancreatic tumors Minerva Chir. 2017 Mar 27. doi: 10.23736/S0026-4733.17.07350-3

6.    Eugenia Yiannakopoulou A Case Approach to Perioperative Drug-Drug Interactions. Anesth Analg. 2017 Mar 24. doi: 10.1213/ANE.0000000000001981.

7.    Eugenia Yiannakopoulou Botulinum toxin and safety issues in cerebral palsy. Dev Med Child Neurol. 2017 Mar;59(3):245.

8.    Eugenia Yiannakopoulou  Robotic assisted adrenalectomy: surgical techniques, feasibility, indications, oncological outcome and safety: Systematic Review Int J Surg. 2016 Apr;28:169-72

9.    Eugenia Yiannakopoulou, Carole Mathelin ONCOPLASTIC BREAST CONSERVING SURGERY AND ONCOLOGICAL OUTCOME: SYSTEMATIC REVIEW Eur J Surg Oncol. 2016 May;42(5):625-30

10.     Eugenia Yiannakopoulou Sclerotherapy of varicose veins and safety issues Pharmacology 2016 Apr 23;98(1-2):62-69

11.    Eugenia Yiannakopoulou Minimally invasive pancreatic surgery Minerva Chir. 2015 Dec;70(6):437-50

12.    Eugenia Ch Yiannakopoulou Pharmacogenomics and Opioid Analgesics: Clinical Implications Int J Genomics. 2015;2015:368979

13.    Eugenia Ch Yiannakopoulou Targeting DNA Methylation with Green Tea Catechins Pharmacology. 2015 Mar 13;95(3-4):111-116

14.    Eugenia Ch Yiannakopoulou Serious and long-term adverse events associated with the therapeutic and cosmetic use of botulinum toxin Pharmacology. 2015;95(1-2):65-9. doi: 10.1159/000370245. Epub 2015 Jan 21

15.    Eugenia Ch Yiannakopoulou Pharmacovigilance for novel oral anticoagulants: why is it so crucial? J Pharmacovigilance 2015 in process

16.    Eugenia Ch Yiannakopoulou Interaction of green tea catechins with breast cancer endocrine treatment: a systematic review Pharmacology. 2014;94(5-6):245-8. doi: 10.1159/000369170. Epub 2014 Nov 28

17.    Eugenia Ch Yiannakopoulou Interaction of Salicylates and the Other Nonsteroidal Anti-Inflammatory Agents With Breast Cancer Endocrine Treatment: Systematic Review Am J Clin Oncol. 2014 Dec 10. [Epub ahead of print]

18.    Yiannakopoulou E, Nikiteas N, Perrea D, Tsigris C Virtual reality simulators and training in laparoscopic surgery Int J Surg.  2015 Jan;13:60-4. doi: 10.1016/j.ijsu.2014.11.014. Epub 2014 Nov 18

19.    Eugenia Ch Yiannakopoulou Aspirin and NSAIDs for breast cancer chemoprevention Eur J Cancer Prev. 2014 Nov 6. [Epub ahead of print]

20.    Eugenia Ch Yiannakopoulou Targeting epigenetic mechanisms and microRNAs by aspirin and other non steroidal anti-inflammatory agents--implications for cancer treatment and chemoprevention Cell Oncol (Dordr). 2014 Jun;37(3):167-78.

21.    Eugenia Ch Yiannakopoulou Etiology of familial breast cancer with undetected BRCA1 and BRCA2 mutations: clinical implications. Cell Oncol (Dordr). 2014 Feb;37(1):1-8. doi: 10.1007/s13402-013-0158-0. Epub 2013 Dec 4

22.    Eugenia Ch Yiannakopoulou Green tea catechins: Proposed mechanisms of action in breast cancer focusing on the interplay between survival and apoptosis Anticancer Agents Med Chem. 2014 Feb;14(2):290-5

23.    Eugenia Ch Yiannakopoulou Pharmacovigilance and NSAIDs J Pharamcovigilance 2014  http://dx.doi.org/10.4172/2329-6887.1000e116

24.    Eugenia Ch Υiannakopoulou Targeting oxidative stress response by green tea polyphenols: clinical implications Free Radic Res. 2013 Sep;47(9):667-71

25.    Eugenia Ch Υiannakopoulou Effect of green tea catechins on breast carcinogenesis: a systematic review of in-vitro and in-vivo experimental studies Eur J Cancer Prev 2013 Aug 9

26.    Eugenia Ch Υiannakopoulou , Nikolaos  Νikiteas , Despina Perrea ,  Christos Tsigris Effect of laparoscopic surgery on oxidative stress response: Systematic Review Surg Laparosc Endosc Percutan Tech. 2013 ;23(2):101-8

27.    Υiannakopoulou Eugenia, Νikiteas Nikolaos, Perrea Despina, Tsigris Christos. Minimally invasive surgery and stress response Systematic review of animal data Surg Laparosc Endosc  Percutan Tech 2013; 3:101-8

28.    Yiannakopoulou E Pharmacogenomics of acetylsalicylic acid and other nonsteroidal anti-inflammatory agents: clinical implications Eur J Clin Pharmacol In Press

29.    Eugenia Ch Yiannakopoulou Pharmacogenomics of phase II metabolizing enzymes and drug transporters: clinical implications  Pharmacogenomics J 2013 13:105-9

30.    Eugenia Yiannakopoulou Does Pharmacodynamic Interaction of Non Enzymatic Antioxidants Modify Response to Anti-Oxidant Therapy in the Process of Atherosclerosis? J Cardiovasc Pharmacol 2012;17:366-72

31.    Eugenia Yiannakopoulou Modulation of lymphangiogenesis: a new target for aspirin and other non steroidal anti-inflammatory agents? Systematic Review Clin Pharmacol. 2012;52:1749-54

32.    Eugenia Ch Υiannakopoulou, Nikolaos  Νikiteas, Despina Perrea,  Christos Tsigris Pharmacological preconditioning of oxidative stress response: Systematic Review Surg Laparosc Endosc  Percutan Tech 2012 22;200-204

33.    Eugenia Yiannakopoulou Pharmacogenomics of breast cancer targeted therapy: focus on recent patents Recent Pat DNA Gene Seq 2012;6:33-46

34.    Eugenia Yiannakopoulou Recent patents on antibacterial, antifungal and antiviral properties of tea Recent Pat Anti-infect Drug Discov 2012;7:60-65

35.    Eugenia Yiannakopoulou Botulinum toxin and anal fissure: Efficacy and safety-Systematic Review Int J  Colorectal Dis 2012;1:1-9

36.    J Griniatsos, E. Yiannakopoulou, H. Gakiopoulou, A.Alexandrou, N. Dimitriou, I. Karavokyros, E. Felekouras Clinical implications of the histologically and immunohistochemically detected solitary lymph nodes metastases in gastric cancer Scand J Surg 2011;100:174-180

37.    Yiannakopoulou E. Hemoptysis under diclofenac and antiplatelet doses of aspirin. Pharmacology 2011;87:1-4

38.    Yiannakopoulou E Effect of aspirin in hemostasis: synergism or antagonism with non steroidal anti-inflammatory agents. IIOAB Journal 2010 1;29-32

39.    Griniatsos J, Alexandrou A, Yiannakopoulou E A SIMPLE TECHNIQUE FOR VACUUM DRAINAGE OF THE PERITONEAL CAVITY IN THE MANAGEMENT OF ANASTOMOTIC LEAKS Accepted for publication in Journal of Buon

40.    Yiannakopoulou E 7th Biennial Congress of the Mediterranean Society of Coloproctology (MSCP), Thessaloniki Greece, April, 22-24, 2010 Tech Coloproctol 2010;14:291-292

41.    E. Yiannakopoulou and E. Tiligada Preconditioning effect of salicylates against oxidative stress in yeast. Journal of Applied Microbiology 2009;106:903-908

42.    Ε.Yiannakopoulou Methodological issues regarding safety evaluation in randomized controlled trials of the effectiveness of antibiotic prophylaxis for the prevention of postoperative wound infection.  J Antimicrob Chemother  2009 ;63:843-845

43.    Griniatsos J, Yiannakopoulou E, Tsehpenakis A, Tsigris Ch, Diamantis Th.  Α Hybride technique for recurrent incisional hernia repair. Surg Laparosc Endosc Percutan Tec 2009;19:e177-e180

44.    Griniatsos J, Gakiopoulou H, Yiannakopoulou E, Dimitriou N, Douridas G, Nonni A, Liakakos Th, Felekouras E.  Routine modified D2 lymphadenectomy performance in pT1-T2N0 gastric cancer tumors World J Gastroenterol 2009;28:5568-5572 

45.    Yiannakopoulou Eugenia Oxidative stress-antioxidant mechanisms-clinical implications Archives of Greek Medicine 2009;26:23-35

46.    E. Yiannakopoulou Gynaecomastia and statins Epitheor Pharmacol Pharmacokinet 2009;27:19-22

47.    C.E.Tourmousoglou, E.Ch.Yiannakopoulou, V.Kalapothaki, J.Bramis, J.St.Papadopoulos Adherence to guidelines for antibiotic prophylaxis in general surgery: a critical appraisal. Journal of Antimicrobial Chemotherapy 2008;61:214-218

48.    C.E.Tourmousoglou, E.Ch.Yiannakopoulou, V.Kalapothaki, J.Bramis, J.St.Papadopoulos Surgical Site Infections Surveillance in general surgery: a critical issue Journal of Chemotherapy 2008;20:312-318 

49.    E.Ch Yiannakopoulou Cephalosporin induced anaemia in surgical patients Review of Clinical Pharmacology and Pharmacokinetics International Edition 2008; 22:363-365

50.    Ε.Ch Yiannakopoulou and E.Tiligada Pharmacological preconditioning in the oxidative stress response of eukaryotic cells: In process method validation Review of Clinical Pharmacology and Pharmacokinetics Greek Edition* 2007;25:30-32

51.    C.E.Tourmousoglou, E.Ch.Yiannakopoulou, V.Kalapothaki, J.Bramis, J.St.Papadopoulos Antibiotic prophylaxis and adverse reactions of antibiotics in general surgery Review of Clinical Pharmacology and Pharmacokinetics International Edition 2006;20:338-340

52.    Ε.Ch Yiannakopoulou and E.Tiligada Acetaminophen modulates the oxidative stress response in eucaryotic cells Review of Clinical Pharmacology and Pharmacokinetics International Edition 2006;20:125-127

53.    Eugenia Ch.Yiannakopoulou, John S.Papadopulos, Dennis V. Cokkinos, Theodoros D. Mountokalakis Adherence to antihypertensive treatment: a critical factor for blood pressure control Eur J Cardiovasc Prev Rehabil 2005;12:243-249

54.    E.Ch Yiannakopoulou, C.Damianou, C.Bamia, J.S.Papadopoulos Adequacy of safety data reporting in randomized clinical trials comparing coxibs with non-selective NSAIDs. Epitheor. Klin. Farmakol. Farmacokinet.* 2005;23:42-43

55.     Ε.Ch.Yiannakopoulou, A.Delitheos, E.Tiligada  Dose-dependent effect of non-steroidal anti-inflammatory agents on the cellular stress response Epitheor. Klin. Farmacol. Farmakokinet.  2005;23:39-41

56.    Τourmousoglou CE, Kalapothaki V, Yiannakopoulou E, Bramis J, Papadopulos JS Evaluating the adequacy of the prophylactic usage of antimicrobial drugs in surgical patients Review of Clinical Pharmacology and Pharmacokinetics International Edition* 2002;16: 27

57.    E.Ch.Yiannakopoulou, J.S.Papadopulos, D.Cokkinos, T.Mountokalakis Side effects of antihypertensive medicines and how they influence the quality of treatment Review of Clinical Pharmacology and Pharmacokinetics, International Edition* 2002;16:109-110

Research Interest: His interests in liver fibrosis research focuses on the use of intrahepatic administration of collagenase for reversal of liver fibrosis and this work was one of the earliest that established proof-of-principle of these potential therapeutic agents. His immunological interest lies with double-stranded RNA induced immune response and its potential application in anti-virus and/or anti-cancer immunotherapy.

Research Interest: Immunology, Cancer, ImmunoTherapy, Autoimmunity

Research Interest: Tumor types: ovarian, breast, lung, liver

2. reactive oxygen and carcinogenesis

3. signal transduction

4. control of cell cycle progression

6. drug resistance in vitro

8. tubulin-targeted agents and alkylating agents

9. mechanism of drug action/new molecular targets/therapeutics

a) molecular mechanisms of epothilones, taxanes and anthracyclines activity in cancer and normal cells

b) pharmaceutical agents (metformin, gliclazide, sitagliptin) used for prevention of

  diabetes complications

10. drug discovery technologies/combination chemotherapy