Research Interest:  Obesity, metabolic syndrome, diabetes type 2,dyslipidemia,hypertension.

Research Interest: Polymer-based inorganic nanocomposite, biomass composite materials

Research Interest: Studying the pathogenic process in betanodavirus and iridovirus infection in grouper GF-1 and larval grouper fish systems. His laboratory pioneered the use of grouper model to study betanodavirus in vivo on brain damaged, which as a model. 

Research Interest: Polyhydroxyalkanoates (PHAs), bioprocess engineering, biopolymer fermentation, biogas, environmental biotechnology, and environmental microbiology

Research Interest: Pharmacology/Toxicology Isolation and Identification of Natural products, Drug Discovery and Development, Cellular and Molecular Biology of Diseases 

Research Interest: Biological activity of blood platelets; inflammatory properties of platelets; interaction of blood platelets with the cells of the immune system; autoimmune diseases; activation and platelet reactivity in neurodegenerative diseases (multiple sclerosis); proteome, transcriptome and metabolome of platelets; molecular markers of platelets in the diagnosis of acute coronary syndromes

Research Interest:  Silica based hybrids by a sol-gel    process, calcium phosphate bioceramics for bone repairs, biomimetisc crystal growth of calcium phosphate.

Research Interest: Polymeric Biomaterials and Green Materials: -Synthesis and Characterization, Surface Modification, and Patterning (soft and dip-pen lithography) and Polymers processing, Synthesis of Polyurethanes/Polyesters and Bio-based resins. Nanomaterials and Energy Materials: Polymer-HA or Polymer-CNT Nanocomposites, Synthesis of Nanofibers and Nanoparticles for cancer drug delivery, Chemical modification of Nanodiamond particles and Metallization of CNTs, Polymeric and silica Nanorods as reinforcing fillers for dental restoration materials for flowable composites), Polymer/graphene composite materials and Polymer/polyoxometalate composites for energy applications. Tissue Engineering/ Drug Delivery: Polymeric 3D-Nanofibrous Scaffolds for Bone, Vascular, Neural and Dental, Salivary glands and multifunctional nanoparticles for lung cancer drug and growth factor delivery, Nasal/mucosal delivery of therapeutics), Electrospining and Force-spinning techniques for polymer and ceramic composite nanofabrication. Additive bio-manufacturing and We-laid Process for biomaterials/scaffolds of complex tissues and interfaces. Characterization of Materials: Microscopic and Spectroscopic characterization (SEM, AFM, FT-IR, XPS), mechanical properties characterization (Tensile, compression, dynamic mechanical (DMA) and nanoindentation), thermal properties (TGA, DSC, TMA) and Rheological characterization of polymeric biomaterials, nanomaterials and hybrid polymer/inorganic composites and in vitro Cell Studies for biocompatibility and toxicity. In Vitro Evaluation of nano-structured materials/ nanodiamond wear-debris from orthopedic joint implants: Nanoscaled wear-debris isolation from Hip and knee Simulator (AMTI) and its inflammatory effect evaluation.

Research Interest: Production of monoclonal and polyclonal antibodies Microbiology and Immunology Development of biomedical protein chips  Development of mmunochromatographic strip with nano-gold particle technique Immunosensing analysis technique: Surface plasmon resonance (Optical sensor) and Quartz crystal microbalance (Piezoimmunosensor)

Research Interest:  Neurogenesis. Screening the leading chemical to stimulate the neurogenesis after CNS, diseases, including: Stroke, Multiple sclerosis, Alzheimers disease et al.  Brain tumor. To study the oncogenesis mechanisms of mellablastoma and glioblastoma.At the same time, to screen the inhibitor of Sonic hedgehog pathway to treat the brain tumor.

Research Interest: Aspect of biochemistry, molecular biology, endocrinology, metabolism, nutrition, pharmacology, and toxicology. Dr. Yamaguchi has an interesting for cell signaling mechanism, bone biology, nutritional factor and osteoporosis prevention, diabetes and diabetic osteoporosis, cancer biology, and cancer bone metastasis. Dr. Yamaguchi discovered two novel proteins and genes; cell signaling suppressor protein (named regucalcin; 1978) and transcriptional factor RGPR-p117 (regucalcin gene promoter region-related protein; 2001) in mammalian cells. Dr. Yamaguchi generated regucalcin transgenic rats, which were registered as international patents (USA, EU, Japan, and Korea), and this animal was found to induce osteoporosis and hyperlipidemia. Moreover, Dr. Yamaguchi proposed the potential role of regucalcin as a key suppressor protein in carcinogenesis.  Currently, the research of regucalcin is focused as a scientific topic 

Research Interest:  pharmacological approaches in human ex vivo / in vitro models targeted against inflammation&proliferation&migration in atherosclerosis and restenosis following angioplasty.

Research Interest: With a combination of molecular biology, biochemistry, cell biology, nutrition metabolism,transgenic/knockout mice model, I aim to uncover the complex molecular programs that regulates physiological or pathological biological pathways, such as cell commitment, cell metabolism, embryonic development, brain development, nutrition regulation, and the pathological mechanisms of human metabolic diseases, such as obesity, diabetes and neurological disease..

Research Interest: Regulation of extracellular matrix genes and growth factors by potential anti-skin aging, anti-carcinogenic or wound repair agents in normal or cancer cells:Area of Expertise: Biochemistry and Cell/Molecular Biology; Biotechnology: Cell culture, Gene Regulation (protein, mRNA, promoter levels), Extracellular matrix (collagen, matrixmetalloproteinases, elastin, fibrillin), Growth factors/cytokines (tranaforming growth factor-b, interleukins), Oxidative Stress/Reactive Oxygen species, Antioxidants, Apoptosis, Toxicity, Angiogenesis/Metastasis.

Research Interest: Molecular biology as well as signaling pathways involved in apoptosis.