Wei Min HUANG
Nanyang Technological University, Singapore
Email: email@example.com, firstname.lastname@example.org
Tel: 0065 84664500
Fax: 0065 67924062
Carlo Massaroni was born in Anzio (Rome) in 1988.
He received the B.S. Degree in Biomedical Engineering from Università Campus Bio-Medico di Roma in December 2010. The Bachelor thesis title was "Perception Analysis of the form by the use of a numerical chessboard" and it was carried out in collaboration with the Bioinformatics Lab of the same University.
He received the M.S. Degree with highest honors in Biomedical Engineering from Università Campus Bio-Medico di Roma in December 2012. His graduation Thesis was entitled "Preliminary validation of a respiratory apparatus simulator for the assessment of metrological characteristics of a optoelectronic plethysmograph".
With his thesis he won two relevant National Price. On September he has been awarded the 2013 SIAMOC Dissertation Prize by the Italian Society of Clinical Movement Analysis (SIAMOC) in recognition of the outstanding quality of his undergraduate research. On October he has been awarded the 2013 GNB Dissertation Price by the Italian National Bioengineering Group (GNB) for outstanding contribute in the field of Rehabilitation and Prosthetics.
From April 2013 to January 2014 he worked as Biomechanical Researcher in the Unit of Rehabilitation at Scientific Institute for Research IRCCS Eugenio Medea of Conegliano (TV), as Scholarship Winner and Assignee for 2013.
He was PhD Student in Biomedical Engineering at Università Campus Bio-Medico di Roma from January 2014 to December 2016: he started working in the Laboratory of Measurements and Biomedical Instrumentation in January 2014, under the supervision of Prof. Sergio Silvestri.
In 2014 he has achieved the Professional Qualification as Industrial Engineer (Section A). He was Jury Aggregate Member as Topic expert in Biomedical Instrumentation during the State Examinations enabling the exercise of the profession of Engineer on behalf of Ordine degli Ingegneri of Rome. Section A - Industrial Section.
From February 2015 is Student Mentor for the International Biomechanics Society (ISB) in Instrumentation for Human Motion, Optoelectronic Systems and Optoelectronic Plethysmography.
On July 2015 he has been awarded the International Grant Travel Program Award by the International Society of Biomechanics (ISB) with the project "MoCBA - MOtion Capture for Breathing Assessment". MoCBA is an interdisciplinary project taking advantage of the research cooperation between the School of Sport & Exercise Sciences (SSES) at the University of Kent (Dr. Dickinson and Dr. Winter) and the School of Engineering, Research Unit of Measurement and Biomedical Instrumentation (UCBM) at the Campus Bio-Medico di Roma University. He is currently (until 22/04/2016) a Visiting PhD Student at University of Kent (Medway Campus, Kent, UK), where he is working in the Respiratory Clinic Unit.
On September 2017 he has been awarded the 2017 GNB Thesis Award by the Italian National Bioengineering Group (GNB) for outstanding contribute in the field of Biorobotics and Biomechanics.
2017 IEEE Sensor Council Travel Award (€ 1000) to attend the 2nd IEEE Sensors Summer
School on Optical Fibre Sensors at the University of Limerick, Ireland. 26th – 30th
June 2017 - Limerick, Ireland.
2016 European Society of Biomechanics (ESB) Travel Award (€ 400) to attend the 22nd
Congress of the European Society of Biomechanics (Respiratory Biomechanics
Session) - Lyon, France.
2015 International Society of Biomechanics (ISB) International Travel Grant (ITG2015) ($
2500) to fund the Research Project “MoCBA: Motion Capture for Breathing
Assessment” and to fund the foreign period of 6 months at University of Kent (UK).
Number of Publications: 43
Image / signal processing,
Machine learning, Computer-aided clinical diagnosis and treatment selection
fatigue, motor units, innervation zone, anal sphincter, MMG, biofeedback,
cervical kinematics, helical axis
Research Interest: His research interests concentrate on the
biosensors (e.g. living cell sensor, DNA sensor and protein sensor) and BioMEMS
Shape memory materials and
composites (bulk and thin film), Laser annealing and micro fabrication, Thin
films (characterization and materials/devices) Micro/nano mechanics, nano
patterning and indentation technology, Surface and optical properties of smart
materials. Advanced and novel materials.
Micro assembly and packaging, active
disassembly. Deployable and bi-stable structures. Materials selection Flight
mechanism in inserts Micro biomedical devices
Bone and cartilage disease
modeling, drug screening and gene correctionDirect differentiation of
pluripotent stem cells toward cartilage and boneBone reprogramming of fibroblasts
using defined factors Gene therapy for cartilage regeneration and repair in
regenerative medicine Signaling pathway of genes regulating cartilage
differentiation of human mesenchymal stem cells.Molecular basis of mesenchymal
stem cells maintaining their stemness. Stem cell biology and technique
Connective Tissue, Drugs
Action, Microscopy, Protein Modeling, Bone Structure, Trace/major Elements,
Image Processing, Electromagnetism, Spectroscopy, Biometrics, Human Networks
Research Interest: Cell Printing, Now, he is especially
interested in the novel cell printing method. With the different own designed
cell printers, the project about how to printing vessels and the organ at the
same time is underway. Organ on a chip, Now, he is especially interested in
designing new method to 3D printing microfluidic chips which can be used in cell
culture and the prototype of organ
Scaffold Design For Tissue
Engineering, Composites hydrogels For Bone Repair, Electrospinning and
Electrospraying technology, Scanning and Trasmission Electron Microscopy, Image
Analysis For Porosity Measurements, Chemical And Physical Properties
Characterization Of Composite And/Or Polymeric Substrates, Injectable Composite
Cements For Bone Cavity Filling.
Research Interest: Basic experiment skills in molecular and cell biology, immunology and zoology as follows: Molecular biology:Regular skills of molecular biology;plasmid construction, including shRNA and overexpression, GFP fusion protein, nucleic acid extraction, purification. Biochemistry: protein expression analysis, including western blotting, immunoprecipitation and quantitative real-time RT-PCR; E.coli expressionsystem, soluble and insoluble protein purification. Cell biology: Mammalian cell culture; plasmid transfection; development of stable transfected cell lines; immunohistochemistry; immunocytochemistry. Others: Basic animal, especially mouse and rat handling skills;drosophila culture; familiar with ordinary operation of laser scanning confocal microscopy (Leica,Zeiss,Olympus), fluorescence microscopy, fluorescence spectrometer;familiar with ordinary statistic and bioinformatical softwares.
Dr. Mohammed Rachidi received his PhD/ Doctorate Degree in Human and Molecular Genetics (with High Honors) at the prestigious ''Pasteur Institute'' (Paris, France), in the Department of Molecular and Cellular Genetics headed by the Professor François JACOB (Nobel Prize in Physiology/Medicine), where he studied the Cellular & Molecular Mechanisms underlying Brain Morphogenesis, Visual System development, CaMKinases & Biological Clock Function in Drosophila. Dr. Rachidi extended these Molecular Genetics works to Functional Genomics at Pasteur Institute and at Center National of Research Scientific CNRS and played key fundamental roles in different collaborative research projects with prestigious laboratories in Europe, Japan & United States. Remarkably, Dr. Rachidi collaborated with the Professor Michael ROSBASH (Nobel Prize in Physiology/Medicine 2017) in the Molecular Mechanisms of 2 genes involved in Circadian Clock. Dr. Rachidi published with Professor ROSBASH this important work in the EMBO Journal Entitled : ''A New Gene encoding a putative Transcritpion Factor Regulated by the Drosophila Circadian Clock''. Postdoctoral training & Assistant Professor with Professor Nicole LeDOUARIN at the prestigious ''College De France'' & Institute of Cellular & Molecular Embryology (Paris), Dr. Rachidi studied some Chicken & Xenopus molecules acting in Bone Morphogenetic Protein BMP signaling pathways and identified their Mouse & Human homologs involved in differentiation of specific domains of neuronal progenitors, in cerebellum development and Joubert syndrome (a form of cerebellar ataxia). These experiences of Dr. Rachidi in the Molecular Genetics and in several Animal Models were extended to Human Molecular Genetics of Down syndrome (DS) & to Molecular and Cellular Mechanisms underlying Brain morphogenesis of Trisomic & Transgenic Mouse Models of DS and also of numerous stages of Embryonic & Fetal DS patients to elucidate the Neurogenetic Basis of Functional alterations Associated with Mental Retardation. Director of Research in Human Molecular Genetics, Faculty of Medicine University Paris 5 (France), with High Honours for Notable Scientific Research Contributions, Breakthroughs & Discoveries in Drosophila & Mouse & Human Molecular Genetics & Neurosciences, Dr. Rachidi has vast experiences with different Research Interests in Modern Molecular Genetics, Neuroscience & Biomedical Research. Dr. Rachidi realized numerous ''Discoveries and Innovations'' to name a few: (1) - Discovery of Quantitative Assessment of Gene [removed]QAGE) as a New Method in situ detecting Differential Overexpression of Candidate Genes for Mental Retardation in Down syndrome Brain Regions & for Other Diseases caused by Regionalized Quantitative Transcriptional Alterations for greater interpretation of functional processes driving gene expression. (2) - Discovery of New Cerebellar & Cerebral Phenotypes in Transgenic mouse in vivo Library of Human Down syndrome Critical Region. (3) - Discovery of a Novel Light Microscopy Technology as Powerful Tool in Developmental Biology & Biomedical & Neuroscience Research. (4) - Discovery of New Genes involved in Brain Morphogenesis & in Visual System development; in Biological Clock; in Learning & Memory and in Mental Retardation in Down syndrome & Joubert syndrome. (5) - Discovery of the First Proposed Model of Molecular and Cellular Mechanism Elucidating Neurogenetic and Neurocognitive Basis of Functional Impairments Associated with Mental Retardation in Down syndrome: in this Model Gene Dosage Effects on transcriptional variations and the nature of gene products and their functional relationships are explained with the different aspects of neuronal differentiation. Dr. Rachidi published numerous articles in highly Prestigious International Journals with High Impact Factor like EMBO, Genomics, DNA Research, Gene, Mechanisms of Development, Cytogenetics & Genome Research, Neuroscience Research, International Journal of Developmental Neuroscience, Cell Tissue Research, American Journal of Intellectual Developmental Disability, European Journal of Paediatric Neurology...and in numerous journals of Elsevier & Springer. He has also authored numerous Chapters & Books. Dr. Rachidi has been honoured worldwide as Invited Distinguished Speaker, Chairman or Invited Honourable Organizing Committee Member in numerous International Conferences, Seminars & Workshops in Europe, USA & Asia. Dr Rachidi received numerous Awards & Honors and He is an Editor, Associate Editor, Executive Editor & Editor in Chief in numerous International peer-reviewed Journals.
Dr. Mohammed Rachidi has vast experiences with different Research Interests in Modern Molecular Genetics, Neurosciences & Biomedical Research, to name a few : Cellular & Molecular Mechanisms underlying Brain Morphogenesis, Visual System, Biological Clock, Synaptic Protein Targeting, Synaptic Plasticity, CaMKII & CAMGUK/MAGUK, Learning and Memory. Functional Genomics & Mechanisms controlling Transposition at Cell Cycle. Transcription, Protein Translation & Virus-Like Particle Formation. Bone Morphogenetic Protein BMP signaling pathways, Mouse and Human Homeobox Genes, Cell Fate Determination and Differentiation, Neuronal Progenitors in Cerebellum development and Joubert syndrome. Trisomy 21, Intellectual Disability, Candidate Genes, Expression studies, Genotype-Phenotype Associations, Trisomic and Transgenic Mouse Models of Down syndrome, Neurogenetic and Neurocognitive Basis of Functional Impairments Associated with Intellectual Disability. Drosophila & Mouse & Human.
List of Publications:
- Rachidi, M. (2019). Pharmacotherapeutic Challenges for Rescuing Mental Retardation and Improving Brain Function in Down Syndrome. Biophamaceutics and Therapeutic Challenges, 2019, (In Press).
- Rachidi, M. (2018). The Genetic Dosage Imbalance Linked to Clinical Brain Alterations and Mental Disability in Down syndrome could be Targeted for Therapeutics Development.
Medical Journal of Clinical Trials and Case studies. 2018, 2 (5): 000150.
- Rachidi, M. (2018). The Molecular Pathogenesis of Down Syndrome-Associated Diseases and the Promising Potential Therapeutic Targets.
Clinical and Medical Investigations, 2018, Vol. 3(1), 1-2.
- Rachidi, M. (2018). Trisomy of Chromosome 21 provides a Genetic Model for the Role of Aneuploidy in Cell Cycle Alterations, Leukemia, Tumors and Cancer (In Press).
- Rachidi, M. (2016). Neurogenetic Disorders of Down Syndrome and Potential Pharmacotherapies for Mental Retardation.
American Journal of Clinical Neurology and Neurosurgery, 2016, Vol. 2, No. 4, 2016, pp. 45-49.
- Rachidi, M. (2015). Towards the Identification of Genetic Targets for Therapeutics of Intellectual Disability in Down syndrome.
J.J. Cenetics, 2015.
- Rachidi, M. and Lopes, C. (2013). Mental Retardation and Human Chromosome 21 Gene Overdosage: From Functional Genomics and Molecular Mechanisms towards Prevention and Treatment of the Neuropathogenesis of Down Syndrome.
Handbook of Neurochemistry and Molecular Neurobiology. In Genomics, Proteomics, and the Nervous System, Advances in Neurobiology, Springer Publishers 3rd Ed 2013.
- Rachidi M., Tetaria C., Lopes C. (2011). “Cell cycle alteration in Down syndrome”. In Berhardt LV. (Ed.), Advances in Medicine and Biology, 2011, Vol. 20. Nova Science Publisher.
- Rachidi, M. and Lopes, C. (2010). Molecular and Cellular Mechanisms Elucidating the Neurocognitive Basis of Functional Impairments Associated with Intellectual Disability in Down syndrome.
American Journal of Intellectual Developmental Disabilities, 2010; 115., 83-112.
- Rachidi, M. and Lopes, C. (2010). Cell Cycle Alteration in Down syndrome.
International Journal of Medical and Biological Frontiers, 2010, Volume 16, Issue 3/4, Nova Science Publishers.
- Rachidi, M. and Lopes, C. (2009). Gene Expression Regulation in Down syndrome: Dosage Imbalance Effects at Transcriptome and Proteome Levels. Handbook of Down syndrome Research, Edition Nova Science Publishers, Inc., 2009, 55-87
- Rachidi, M., Delezoide, A-L., Delabar, J.M. and Lopes, C. (2009). A quantitative assessment of gene [removed]QAGE) reveals differential overexpression of DOPEY2, a candidate gene for mental retardation, in Down syndrome brain regions.
International Journal of Developmental Neuroscience, 2009, 27, 393-398.
- Rachidi, M., Tetaria, C., and Lopes, C. (2008). Trisomy of Human Chromosome 21 and Cell Cycle Control. In Leroy NH., Fournier NT. (Eds.): Cell Cycle Control: New Research, Nova Science Publishers, Inc., 2008, 159-189.
- Rachidi, M. and Lopes, C. (2008). Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways.
European Journal of Paediatric Neurology, 2008, 12, 168-182.
- Rachidi, M. and Lopes, C. (2008). Molecular Mechanisms of Mental Retardation in Down syndrome. Rachidi, M. and Lopes, C. (Editors), Nova Biomedical Book: Edition Nova Science Publishers, Inc., 2008, pp 1-94.
- Rachidi, M., Lopes, C.; C Vayssettes, D J. Smith, E M Rubin, J.M Delabar. (2007). New Cerebellar Phenotypes in YAC Transgenic mouse in vivo Library of Human Down syndrome Critical Region 1.
Biochemical Biophysical Research Communications, 2007, 364(3), 488-494.
- Rachidi, M. and Lopes, C. (2007). Molecular Mechanisms of Mental Retardation in Down Syndrome. In Carson MI. (Ed.): Focus on Mental Retardation Research. Nova Science Publishers, Inc. 2007, pp. 77-134.
- Rachidi, M. and Lopes, C. (2007). Mental retardation in Down syndrome: From gene dosage imbalance to molecular and cellular mechanisms.
Neuroscience Research, 2007, 59(4), 349-369.
- Rachidi, M. and Lopes, C. (2006). Differential transcription of Barhl1 homeobox gene in restricted functional domains of the central nervous system suggests a role in brain patterning.
International Journal of Developmental Neuroscience, 2006, 24(1), 35-44.
- Rachidi, M., Lopes, C., Delezoide, A.L. and Delabar, J.M. (2006). C21orf5, a human candidate gene for brain abnormalities and mental retardation in Down Syndrome.
Cytogenetics and Genome Research, 2006, 112(1-2), 16-22.
- Lopes, C., Delezoide, A.L., Delabar, J.M. and Rachidi, M. (2006). BARHL1 homeogene, the human ortholog of the mouse Barhl1 involved in cerebellum development, shows regional and cellular specificities in restricted domains of developing human central nervous system.
Biochemical Biophysical Research Communications, 2006, 339, 296-304.
- Rachidi, M., Lopes, C., Costantine, M. and Delabar J.M. (2005). C21orf5, a new member of dopey family involved in morphogenesis, could participate to neurological alterations and mental retardation in Down syndrome.
DNA Research, 2005, 12, 203-210.
- Rachidi, M., Lopes, C., Charron, G., Delezoide, AL., Paly, E., Bloch, B. and Delabar, JM. (2005). Spatial and temporal localization during embryonic and fetal human development of the transcription factor SIM2 in brain regions altered in Down syndrome.
International Journal of Developmental Neuroscience, 2005, 23, 475-484.
- Rachidi, M., Lopes, C., Benichou, J.C., Hellio, R. and Maisonhaute, C. (2005). Virus-like particle formation in Drosophila melanogaster germ cells suggests a complex translational regulation of the retrotransposon cycle and new mechanisms inhibiting transposition.
Cytogenetics and Genome Research, 2005, 111(1), 88-95.
- Lopes, C., Chettouh, Z., Delabar, J.M. and Rachidi, M. (2003). The differentially expressed C21orf5 gene in the medial temporal-lobe system could play a role in mental retardation in Down syndrome and transgenic mice. Biochemical Biophysical Research Communications, 2003, 305, 915-924.
- Takamatsu, Y., *Nakagoshi, H., *Rachidi, M., Lopes, C. Nishida, Y. and Ohsako, S. (2002). Characterization of the dCaMKII-GAL4 driver line whose expression is controlled by the. Drosophila Ca²+/calmodulin dependent protein kinase II promoter.
Cell Tissue Research., 2002, 310(2), 237-252.
- Lopes, C., Gassanova, S., Delabar, J.M. and Rachidi, M. (2001). The CASK/Lin-2 Drosophila Homologue, Camguk, Could Play a Role in Epithelial Patterning and in Neuronal Targeting.
Biochemical Biophysical Research Communications, 2001, 284(4), 1004-1010.
- Lopes, C., Rachidi, M., Charron, G., Chamoun, Z., Dahmane, N., Toyama, K., Chettouh, Z., Vekemans, M., Bloch, B., Delezoide, A.L. and Delabar, JM. (2001). Conservation of the CNS expression pattern of new genes from the Down syndrome chromosomal region-1: human genes and their murine orthologs.
Cytogenetics and Cell Genetics, 2001, 92(1-2), 1-22.
- Rachidi, M., Lopes, C., Gassanova, S., Sinet, P.M., Vekemans, M., Attie, T., Delezoide, A.L. and Delabar, J.M. (2000). Regional and cellular specificity of TPRD, the tetratricopeptide Down Syndrome gene, during embryonic development.
Mechanisms of Development, 2000, 93(1-2), 189-193.
- Delabar, J.M., Rachidi, M., Lopes, C., Charron, G., Chamoun, Z, Dahmane, N., Toyama, K., Chettouh, Z., Vekemans, M., Bloch, B. and Delezoide, A.L. (2000). Conservation of the CNS expression pattern of new genes from the Down Syndrome Chromosomal Region-1: Human genes and their Murine orthologs.
European Journal Neuroscience, 2000, 12(Supp 11), 297.
- Orti, R., Rachidi, M., Viallard, F., Toyama, K., Lopes, C., Taudien, S., Rosenthal, A., Sinet, P.M. and Delabar, J.M. (2000). Characterisation of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and its murine ortholog.
Genomics, 2000, 64(2), 203-210.
- Rahmani, Z., Lopes, C., Rachidi, M. and Delabar, J.M. (1999). Expression of the mnb (dyrk) protein in adult and embryonic mouse tissues.
European Journal of Human Genetics, 1999, 7(Supp.1), 111.
- Rachidi, M., Lopes, C., Takamatsu, Y., Ohsako, S., Benichou J.C. and Delabar, J.M. (1999). Dynamic expression pattern of Ca2+/calmodulin-dependent protein kinase II gene in the central nervous system of Drosophila throughout development.
Biochemical Biophysical Research Communications, 1999, 260(3), 707-711.
- Lopes, C., Rachidi, M., Gassanova, S., Sinet, P.M. and Delabar, J.M. (1999). Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1.
Mechanisms of Development, 1999, 84(1-2), 189-193.
- Rahmani, Z., Lopes, C., Rachidi, M. and Delabar, J.M. (1998). Expression of the Mnb (dyrk) protein in adult and embryonic mouse tissues.
Biochemical Biophysical Research Communications, 1998, 253(2), 514-518.
- Rachidi, M., Lopes, C. and Benichou, J.C. (1997). Genetical analysis of visual system disorganizer (vid), a new gene involved in normal development of eye and optic lobe of the brain in Drosophila melanogaster.
Genetica, 1997, 99, 31-45.
- Rachidi, M., Lopes, C., Benichou, J.C. and Rouyer, F. (1997). Analyse of period circadian expression in the Drosophila head by in situ hybridization. Journal of Neurogenetics, 1997, 11, 255-263.
- Rouyer, F., Rachidi, M., Pikielny, C. and Rosbash, M. (1997). A new gene encoding a putative transcritpion factor regulated by the Drosophila circadian clock.
EMBO Journal, 1997, 16(13), 3944-3954.
- Haoudi, A., Rachidi, M., Kim, M.H., Champion, S., Best-Belpomme, M. and Maisonhaute, C. (1997). Developmental expression analysis of the 1731 retrotransposon reveals an enhancement of Gag-Pol frameshifting in males of Drosophila melanogaster.
Gene, 1997, 196 (1-2), 83-93.
- Fassouane, A., Rachidi, M., Rouffaud, M.A., El-Abbouyi, A. and Nguyen, V.H. (1995). In vitro antifungal activity of Bacillus licheniformis FSJ-2 products against dermatophytes.
Journal of Mycology and Medicine, 1995, 5, 244-248.
- Rachidi, M. (1993). The Drosophila visual system: An elaborated building and a powerful model for developmental studies. Biomatec Journal, 1993, 4-5, 2-8.
Research Interest: Synthesis and characterization of inorganic and hybrid organic-inorganic nanomaterials, calcium phosphates, biomaterials, drug delivery, biomineralization and nanomedicine.
Development, Cellular and Tissue Engineering Drug and Gene Delivery, Molecular
Diagnostics Photobioreactor Design
His current research
interests include non-linear analysis of biomedical time series, specially the
analysis of electroencephalographic and magnetoencephalographic recordings to
help physicians in the diagnosis of brain disorders
Surgical planning and
simulation in esthetical facial surgeryTelemedicine o Biomedical engineering
Protein engineering and
protein chemistry, Nanobiotechnology and Protein nanocage, Biomaterials and
Biomedical engineering, Industrial microbiology
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Prof. Pierre Guertin
Laval University, Canada
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Domenico Antonio Restivo
Nuovo Garibaldi Hospital, Italy
Journal of Neurology, Neurological Science and Disorders
University of Parma, Italy
International Journal of Dermatology and Clinical Research
Kyushu University, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
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Rafal Tomasz Pawliczak
Medical University of Lodz, Poland
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Private Compnay- Biological Mimetics, Inc., USA
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