Research Interest: Image / signal processing, Machine learning, Computer-aided clinical diagnosis and treatment selection

Research Interest:  Non-point source, soil heavy metal, absorbing Material, and restoration

Research Interest: Applied research specifically in tissue engineering, biomaterials and regenerative medicine. Currently focus is bionanomedicine, bionanocomposites and bionanotechnology

Research Interest: Bone and cartilage disease modeling, drug screening and gene correctionDirect differentiation of pluripotent stem cells toward cartilage and boneBone reprogramming of fibroblasts using defined factors Gene therapy for cartilage regeneration and repair in regenerative medicine Signaling pathway of genes regulating cartilage differentiation of human mesenchymal stem cells.Molecular basis of mesenchymal stem cells maintaining their stemness. Stem cell biology and technique

Research Interest: Stem cells and Regenerative Medicine, Tissue Regeneration, Tissue Engineering Stem Cells Biology and Differentiation, Stem cells biomaterials interaction, Mechanotransduction

Research Interest: Since 2008 Paola Saccomandi has been involved in research activities in the fields of biomedical instrumentations and measurements applied to medicine. From 2008 to 2011 she worked under the supervisio of Prof. Sergio Silvestri and Dr. Emiliano Schena in the fied of mechanical ventilation. In particular she worked on development of optoelectronic and fiber optic-based flow sensors, as well as on ventilatory gases humidification. In 2011 she started her main research activity in the field of laser ablation of cancer, with particular regard to pancreatic tumor. She developed a mathematic model aiming to predic effects of laser light o pancreas, in terms of ablated volume and temperature distribution. Since 2012 she has been investigating the field of invasive (fiber optic sensors, thermocouples) and non-ivasive (based on diagnostic images) thermometry for temperature monitoring during laser ablation of tumour. In this activity she is actively collaborating with the team of research of the Institute for Diagnostic and Interventional Radiology of J. W. Goethe Universität Frankfurt am Main, headed by Prof. Thomas J. Vogl. Since 2013 she has been working in the fied of optical characterization of biological tissue, aiming to estimate optical properties of pancreas. She is collaborating with the team of Biophysics Institute J. W. Goethe Universität Frankfurt am Main, headed by Prof. Werner Mäntele. In the framework of laser ablation for the removal of pancreatic cancer, she has participated at the study approved by UCBM Ethics Committee -ComEt UCBM-, Prot. N. 4011/2011. The study aims to treat with laser ablation patients with inoperable pancreatic cancer. Since 2014 she is also involved in the design and development of tactile sensors for robotic artificial prosthetics

Research Interest: Nano-Biomaterials Development, Cellular and Tissue Engineering Drug and Gene Delivery, Molecular Diagnostics Photobioreactor Design

Research Interest: His current research interests include non-linear analysis of biomedical time series, specially the analysis of electroencephalographic and magnetoencephalographic recordings to help physicians in the diagnosis of brain disorders

Research Interest: Biophotonics, BioMEMS, Optofluidics, Surface Wettability, Drug Delivery

Research Interest:  His research interests concentrate on the biosensors (e.g. living cell sensor, DNA sensor and protein sensor) and BioMEMS system.

Research Interest: Shape memory materials and composites (bulk and thin film), Laser annealing and micro fabrication, Thin films (characterization and materials/devices) Micro/nano mechanics, nano patterning and indentation technology, Surface and optical properties of smart materials.  Advanced and novel materials.  Micro assembly and packaging, active disassembly. Deployable and bi-stable structures. Materials selection Flight mechanism in inserts Micro biomedical devices

Research Interest: Development of new lanthanide complexes for MRI and optical imaging: synthesis, purification (HPLC, flash chromatography) and physicochemical characterization (NMR spectroscopy, mass spectrometry, luminescence, UV-visible, FTIR).  

Research Interest: Cell and tissue engineering

Dr. Rajasekharredy Pala is a Nano biotechnologist specialized in the synthesis of various metal and metal oxide nanoparticles with their application as drug delivery agents to the primary cilia. After his post-graduation he was selected for ICMR-Senior Research Fellowship under Biomedical Sciences in 2011 and during this period of his doctoral studies at CSIR-Indian Institute of Chemical Technology, India, he has earned handsome experience on the physical and chemical characterizations techniques of nanoparticles that are enveloped with various biologically active compounds such as protein, lipids and small molecular drugs for their biomedical applications. Dr. Pala working as a research associate in Chapman University and University of California Irvine from 2015.

Research Interest: Nanomedicine, Hypertension, Cancer, Renal diseases

URL: https://sites.chapman.edu/cilia/pala-rajasekharreddy/

Skype ID: raaja.biotech

List of Publications: 

Rajasekharreddy Pala, Ashraf M. Mohieldin, Kiumars Shamloo, Rinzhin T. Sherpa, Sarmed H.

Kathem, Jing Zhou, Zhongyue Luan, Jian-Guo Zheng, Amir Ahsan, and Surya M. Nauli.

Personalized Nanotherapy by Specifically Targeting Cell Organelles To Improve Vascular

Hypertension. Nano Letters Article ASAP DOI: 10.1021/acs.nanolett.8b04138

2. Zeng, Y., Zhu, J., Wang, J., Parasuraman, P., Busi, S., Nauli, S. M., Wáng, Y., Pala,

Rajasekharreddy, Liu, G. (2018). Functional probes for cardiovascular molecular

imaging. Quantitative imaging in medicine and surgery, 8(8), 838-852 (co-corresponding

author).

3. Pala, Rajasekharreddy., Jamal, M., Alshammari, Q., Nauli, S.M. The Roles of Primary Cilia in

Cardiovascular Diseases. Cells 2018, 7, 233. (Published as cover page)

4. Rajasekharreddy Pala, Yun Zeng, Subhaswaraj Pattnaik, Siddhardha Busi, Alomari Nedaa,

Nauli Surya M, Gang Liu, (2018). Functionalized Silver Nanoparticles for Sensing, Molecular

Imaging and Therapeutic Applications. Current Nanomedicine, Pages 1 - 17 (17).

5. Pala Rajasekharreddy, Pathipati Usha Rani, Mattapally Saidulu & Sanjay K. Banerjee (2017).

Ultra-small silver nanoparticles induced ROS activated Toll-pathway against Staphylococcus

aureus disease in silkworm model, Materials Science and Engineering: C, 77, 990-1002

(corresponding author).

6. Pala Rajasekharreddy, Chao Huang, Siddhardha Busi, Jobina Rajkumari, Ming-Hong Tai, Gang

Liu (2017). Green Synthesized Nanomaterials as Theranostic Platforms for Cancer Treatment:

Principles, Challenges and the Road Ahead. Current Medicinal Chemistry, 24, 1-17. Doi.

10.2174/0929867324666170309124327.

7. Jobina Rajkumari, Siddhardha Busi, Aneesh Cherukunnel Vasu, Pala Rajasekharreddy (2017),

Facile green synthesis of baicalein fabricated gold nanoparticles and their antibiofilm activity

against Pseudomonas aeruginosa PAO1. Microbial Pathogenesis, 107: 261-269.

8. Rajasekharreddy Pala, Nedaa Alomari, Surya M. Nauli (2017). Primary Cilium-Dependent

Signaling Mechanisms, International Journal of Molecular Sciences, 18, 2272.

9. Kiumars Shamloo, Juan Chen, Jasmine Sardar, Rinzhin T. Sherpa, Rajasekharreddy

Pala, Kimberly F. Atkinson,William J. Pearce, Lubo Zhang, Surya M. Nauli (2017). Chronic

Hypobaric Hypoxia Modulates Primary Cilia Differently in Adult and Fetal Ovine Kidneys.

Frontiers in Physiology, 8: 677.

10. Nauli, Surya M., Rajasekharreddy Pala, and Steven J. Kleene (2016). "Calcium channels in

primary cilia." Current Opinion in Nephrology and Hypertension 25 (5): 452-458.

11. Pala Rajasekharreddy and Pathipati Usha Rani (2014). Biofabrication of Ag nanoparticles using

Sterculia foetida L. seed extract and their toxic potential against mosquito vectors and HeLa

cancer cells. Materials Science and Engineering: C, 39, 203-212.

12. Pala Rajasekharreddy and Pathipati Usha Rani (2014). Biosynthesis and characterization of Pd

and Pt nanoparticles using Piper betle L. plant in a photoreduction method. Journal of Cluster

Science, 25: 1377-1388.

13. Praveen Kumar Kalavagunta, Rajasekharreddy Pala, Usha Rani Pathipati and Narender Ravirala

(2014). Identification of β-Naphthol derivatives as novel antifeedants and insecticides-I. Journal

of Agricultural and Food Chemistry, 62, 6571−6576.

14. Pala Rajasekharreddy and Pathipati Usha Rani (2012) Nontoxic effects of biologically

synthesized silver nanoparticles on silkworm, Bombyx mori L. Hexapoda 19 (1): 74–78.

Pathipati Usha Rani and Pala Rajasekharreddy (2011) Green synthesis of silver-protein (core–

shell) nanoparticles using Piper betle L. leaf extract and its ecotoxicological studies on Daphnia

magna. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 389 (1-3): 188-194.

16. Pathipati Usha Rani, Pala Rajasekharreddy and Kommu Nagaiah (2011). Allelopathic effects of

(2n-octylcycloprop-1-enyl)-octanoic acid (I) against Four Major Weeds. Allelopathy Journal. 28

(2) 179-188.

17. Pala Rajasekharreddy, Pathipati Usha Rani and Bojja Sreedhar (2010). Qualitative assessment of

silver and gold nanoparticle synthesis in various plants: a photobiological approach. Journal of

Nanoparticle Research, 12: 1711-1721.

18. Pala Rajasekharreddy and Pathipati Usha Rani (2010). Toxic properties of certain botanical

extracts against three major stored product pests. Journal of Biopesticides. 3(3): 586-589.

19. Pathipati Usha Rani and Pala Rajasekharreddy (2010). Insecticidal activity of (2n-octylcycloprop-

1-enyl)-octanoic acid (I) against three coleopteran stored product insects from Sterculia foetida

(L.). Journal of Pest Science, 83(3); 273-279.

20. Pathipati Usha Rani and Pala Rajasekharreddy (2009). Toxic and antifeedant activities of Sterculia

foetida (L.) seed crude extract against Spodoptera litura (F.) and Achaea janata (L.). Journal of

Biopesticides 2(2): 161-164.

Pathipati Usha Rani and Pala Rajasekharreddy (2013). Plants: The green factories for synthesis

of nanomaterials” in the book “Nanotechnology Environment” Edited by J.N. Govil. Studium Press

LLC, USA.

A method for isolation of an Ortho Quinone Methide intermediate. Pala Rajasekharreddy

and K.P Kumar and (PCT/IB2015/057628), WIPO publication no. WO/2016/059511.

• Green synthesis of highly monodispersed silver nanoparticles by plant. P. Usha Rani and Pala

Rajasekharreddy (File No. 4020/DEL/2012).

• Novel synthesis of 2-aminobenzothiazolomethyl naphthol derivatives and their

antifeedant activity. KP Kumar, Pala Rajasekharreddy, V. Narendar & P. Usha Rani (File No

0802/DEL/2013).

Research Interest:  His research interests concentrate on the biosensors (e.g. living cell sensor, DNA sensor and protein sensor) and BioMEMS system.