Introduction

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    Editor-in-Chief

    Wei Min HUANG

    Wei Min HUANG
    Nanyang Technological University, Singapore
    Email: shape_memory_material@hotmail.com, mwmhuang@ntu.edu.sg
    Tel: 0065 84664500
    Fax: 0065 67924062
    Skype: shape_memory_material@hotmail.com

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    Executive Editors

    Carlo Massaroni
    School of Engineering
    Università Campus Bio-Medico di Roma
    Italy
    c.massaroni@unicampus.it
    ABSE

    Carlo Massaroni was born in Anzio (Rome) in 1988.

    He received the B.S. Degree in Biomedical Engineering from Università Campus Bio-Medico di Roma in December 2010. The Bachelor thesis title was "Perception Analysis of the form by the use of a numerical chessboard" and it was carried out in collaboration with the Bioinformatics Lab of the same University.

    He received the M.S. Degree  with highest honors in Biomedical Engineering from Università Campus Bio-Medico di Roma in December 2012. His graduation Thesis was entitled "Preliminary validation of a respiratory apparatus simulator for the assessment of metrological characteristics of a optoelectronic plethysmograph".

    With his thesis he won two relevant National Price. On September he has been awarded the 2013 SIAMOC Dissertation Prize by the Italian Society of Clinical Movement Analysis (SIAMOC) in recognition of the outstanding quality of his undergraduate research. On October he has been awarded the 2013 GNB Dissertation Price by the Italian National Bioengineering Group (GNB) for outstanding contribute in the field of Rehabilitation and Prosthetics.

    From April 2013 to January 2014 he worked as Biomechanical Researcher in the Unit of Rehabilitation at Scientific Institute for Research IRCCS Eugenio Medea of Conegliano (TV), as Scholarship Winner and Assignee for 2013.

    He was PhD Student in Biomedical Engineering at Università Campus Bio-Medico di Roma from January 2014 to December 2016: he started working in the Laboratory of Measurements and Biomedical Instrumentation in January 2014, under the supervision of Prof. Sergio Silvestri.

    In 2014 he has achieved the Professional Qualification as Industrial Engineer (Section A). He was Jury Aggregate Member as Topic expert in Biomedical Instrumentation during the State Examinations enabling the exercise of the profession of Engineer on behalf of Ordine degli Ingegneri of Rome. Section A - Industrial Section.

    From February 2015 is Student Mentor for the International Biomechanics Society (ISB) in Instrumentation for Human Motion, Optoelectronic Systems and Optoelectronic Plethysmography.  

    On July 2015 he has been awarded the International Grant Travel Program Award by the International Society of Biomechanics (ISB) with the project "MoCBA - MOtion Capture for Breathing Assessment". MoCBA is an interdisciplinary project taking advantage of the research cooperation between the School of Sport & Exercise Sciences (SSES) at the University of Kent (Dr. Dickinson and Dr. Winter) and the School of Engineering, Research Unit of Measurement and Biomedical Instrumentation (UCBM) at the Campus Bio-Medico di Roma University. He is currently (until 22/04/2016) a Visiting PhD Student  at University of Kent (Medway Campus, Kent, UK), where he is working in the Respiratory Clinic Unit.

    On September 2017 he has been awarded the 2017 GNB Thesis Award by the Italian National Bioengineering Group (GNB) for outstanding contribute in the field of Biorobotics and Biomechanics.

    URL: http://mtmbilaben.weebly.com/carlo-massaroni.html

    Grant Details:

    2017 IEEE Sensor Council Travel Award (€ 1000) to attend the 2nd IEEE Sensors Summer
    School on Optical Fibre Sensors at the University of Limerick, Ireland. 26th – 30th
    June 2017 - Limerick, Ireland.
    2016 European Society of Biomechanics (ESB) Travel Award (€ 400) to attend the 22nd
    Congress of the European Society of Biomechanics (Respiratory Biomechanics
    Session) - Lyon, France.
    2015 International Society of Biomechanics (ISB) International Travel Grant (ITG2015) ($
    2500) to fund the Research Project “MoCBA: Motion Capture for Breathing
    Assessment” and to fund the foreign period of 6 months at University of Kent (UK).

    Number of Publications: 43 </xml> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:8.0pt; mso-para-margin-left:0in; line-height:107%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-ansi-language:EN-IN;} </style> List of Publications: 43

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    Editorial Board

    Yan Xie
    Queensland University of Technology
    Australia
    y2.xie@qut.edu.au
    ABSE

    Research Interest: Tissue & organ repair and regeneration, Tissue engineering, Wound healing, Clinical medicine, dimensional tissue equivalent models, Novel wound and scar remediation therapies, Chinese herbal medicine, Growth factor/extracellular matrix protein complexes, Pharmaceutical and drugs

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    Xiaoming Li
    Assistant Professor
    School of Biological Science and Medical Engineering
    Beihang University
    China
    x.m.li@hotmail.com
    ABSE

    Research Interest:  Designing and preparing new nanobiomaterials Characterizing physical and chemical properties, biocompatibility and bioactivity of the nanobiomaterials

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    Aimilia Gastounioti
    Department of Radiology
    University of Pennsylvania
    USA
    aimilia.gastounioti@uphs.upenn.edu
    ABSE

    Research Interest: Image / signal processing, Machine learning, Computer-aided clinical diagnosis and treatment selection

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    Kamil Kuca
    Biomedical Research Center
    University Hospital Hradec Kralove
    Czech Republic
    kamil.kuca@fnhk.cz
    ABSE

    Research Interest: Military toxicology; Acetylcholinesterase reactivators as treatment of nerve agent and pesticide intoxications; Acetylcholinesterase inhibitors in Alzheimer´s disease and Myasthenia Gravis treatment; Synthesis of the detergents as disinfectants, decontamination means and environment for micellar catalysis; Drug design and Development; Chemical warfare agents; Biological warfare agents; Pharmaceutical Industry; Project Management; Scientific Management; Technology Transfer; Commercialization; Fund Raising; Cloud computing; Parallel computing; medical devices development; toxins. 

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    Tong Ming Liu
    Stem cell group
    Genome Institute of Singapore
    Singapore
    dbsliutm@yahoo.com
    ABSE

    Research Interest: Bone and cartilage disease modeling, drug screening and gene correctionDirect differentiation of pluripotent stem cells toward cartilage and boneBone reprogramming of fibroblasts using defined factors Gene therapy for cartilage regeneration and repair in regenerative medicine Signaling pathway of genes regulating cartilage differentiation of human mesenchymal stem cells.Molecular basis of mesenchymal stem cells maintaining their stemness. Stem cell biology and technique

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    Mohammed Rachidi
    Doctor
    Department of Sciences
    University Paris Diderot, Paris
    France
    rachidi.med1@yahoo.com
    ABSE

    Dr. Mohammed Rachidi received his PhD/ Doctorate Degree in Human and Molecular Genetics (with High Honors) at the prestigious ''Pasteur Institute'' (Paris, France), in the Department of Molecular and Cellular Genetics headed by the Professor François JACOB (Nobel Prize in Physiology/Medicine), where he studied the Cellular & Molecular Mechanisms underlying Brain Morphogenesis, Visual System development, CaMKinases & Biological Clock Function in Drosophila. Dr. Rachidi extended these Molecular Genetics works to Functional Genomics at Pasteur Institute and at Center National of Research Scientific CNRS and played key fundamental roles in different collaborative research projects with prestigious laboratories in Europe, Japan & United States. Remarkably, Dr. Rachidi collaborated with the Professor Michael ROSBASH (Nobel Prize in Physiology/Medicine 2017) in the Molecular Mechanisms of 2 genes involved in Circadian Clock.  Dr. Rachidi published with Professor ROSBASH this important work in the EMBO Journal Entitled : ''A New Gene encoding a putative Transcritpion Factor Regulated by the Drosophila Circadian Clock''. Postdoctoral training & Assistant Professor with Professor Nicole LeDOUARIN at the prestigious ''College De France'' & Institute of Cellular & Molecular Embryology (Paris), Dr. Rachidi studied some Chicken & Xenopus molecules acting in Bone Morphogenetic Protein BMP signaling pathways and identified their Mouse & Human homologs involved in differentiation of specific domains of neuronal progenitors, in cerebellum development and Joubert syndrome (a form of cerebellar ataxia). These experiences of Dr. Rachidi in the Molecular Genetics and in several Animal Models were extended to Human Molecular Genetics of Down syndrome (DS) & to Molecular and Cellular Mechanisms underlying Brain morphogenesis of Trisomic & Transgenic Mouse Models of DS and also of numerous stages of Embryonic & Fetal DS patients to elucidate the Neurogenetic Basis of Functional alterations Associated with Mental Retardation. Director of Research in Human Molecular Genetics, Faculty of Medicine University Paris 5 (France), with High Honours for Notable Scientific Research Contributions, Breakthroughs & Discoveries in Drosophila & Mouse & Human Molecular Genetics & Neurosciences, Dr. Rachidi has vast experiences with different Research Interests in Modern Molecular Genetics, Neuroscience & Biomedical Research. Dr. Rachidi realized numerous ''Discoveries and Innovations'' to name a few:  (1) - Discovery of Quantitative Assessment of Gene [removed]QAGE) as a New Method in situ detecting Differential Overexpression of Candidate Genes for Mental Retardation in Down syndrome Brain Regions & for Other Diseases caused by Regionalized Quantitative Transcriptional Alterations for greater interpretation of functional processes driving gene expression. (2) - Discovery of New Cerebellar & Cerebral Phenotypes in Transgenic mouse in vivo Library of Human Down syndrome Critical Region. (3) - Discovery of a Novel Light Microscopy Technology as Powerful Tool in Developmental Biology & Biomedical & Neuroscience Research. (4) - Discovery of New Genes involved in Brain Morphogenesis & in Visual System development; in Biological Clock; in Learning & Memory and in Mental Retardation in Down syndrome & Joubert syndrome. (5) - Discovery of the First Proposed Model of Molecular and Cellular Mechanism Elucidating Neurogenetic and Neurocognitive Basis of Functional Impairments Associated with Mental Retardation in Down syndrome: in this Model Gene Dosage Effects on transcriptional variations and the nature of gene products and their functional relationships are explained with the different aspects of neuronal differentiation. Dr. Rachidi published numerous articles in highly Prestigious International Journals with High Impact Factor like EMBO, Genomics, DNA Research, Gene, Mechanisms of Development, Cytogenetics & Genome Research, Neuroscience Research, International Journal of Developmental Neuroscience, Cell Tissue Research, American Journal of Intellectual Developmental Disability, European Journal of Paediatric Neurology...and in numerous journals of Elsevier & Springer. He has also authored numerous Chapters & Books. Dr. Rachidi has been honoured worldwide as Invited Distinguished Speaker, Chairman or Invited Honourable Organizing Committee Member in numerous International Conferences, Seminars & Workshops in Europe, USA & Asia. Dr Rachidi received numerous Awards & Honors and He is an Editor, Associate Editor, Executive Editor & Editor in Chief in numerous International peer-reviewed Journals.

    Research Interest:

    Dr. Mohammed Rachidi has vast experiences with different Research Interests in Modern Molecular Genetics, Neurosciences & Biomedical Research, to name a few : Cellular & Molecular Mechanisms underlying Brain Morphogenesis, Visual System, Biological Clock, Synaptic Protein Targeting, Synaptic Plasticity, CaMKII & CAMGUK/MAGUK, Learning and Memory. Functional Genomics & Mechanisms controlling Transposition at Cell Cycle. Transcription, Protein Translation & Virus-Like Particle Formation. Bone Morphogenetic Protein BMP signaling pathways, Mouse and Human Homeobox Genes, Cell Fate Determination and Differentiation, Neuronal Progenitors in Cerebellum development and Joubert syndrome. Trisomy 21, Intellectual Disability, Candidate Genes, Expression studies, Genotype-Phenotype Associations, Trisomic and Transgenic Mouse Models of Down syndrome, Neurogenetic and Neurocognitive Basis of Functional Impairments Associated with Intellectual Disability.  Drosophila & Mouse & Human.

    List of Publications:

    - Rachidi, M. (2019). Pharmacotherapeutic Challenges for Rescuing Mental Retardation and Improving Brain Function in Down Syndrome.  Biophamaceutics and Therapeutic Challenges, 2019, (In Press).

    - Rachidi, M. (2018). The Genetic Dosage Imbalance Linked to Clinical Brain Alterations and Mental Disability in Down syndrome could be Targeted for Therapeutics Development.
    Medical Journal of Clinical Trials and Case studies. 2018, 2 (5): 000150.

    - Rachidi, M. (2018). The Molecular Pathogenesis of Down Syndrome-Associated Diseases and the Promising Potential Therapeutic Targets.
    Clinical and Medical Investigations, 2018, Vol. 3(1), 1-2.

    - Rachidi, M. (2018). Trisomy of Chromosome 21 provides a Genetic Model for the Role of Aneuploidy in Cell Cycle Alterations, Leukemia, Tumors and Cancer   (In Press).

    - Rachidi, M. (2016). Neurogenetic Disorders of Down Syndrome and Potential Pharmacotherapies for Mental Retardation.
    American Journal of Clinical Neurology and Neurosurgery, 2016, Vol. 2, No. 4, 2016, pp. 45-49.

    - Rachidi, M. (2015). Towards the Identification of Genetic Targets for Therapeutics of Intellectual Disability in Down syndrome.
    J.J. Cenetics, 2015.

    - Rachidi, M. and Lopes, C. (2013).  Mental Retardation and Human Chromosome 21 Gene Overdosage: From Functional Genomics and Molecular Mechanisms towards Prevention and Treatment of the Neuropathogenesis of Down Syndrome.
    Handbook of Neurochemistry and Molecular Neurobiology. In Genomics, Proteomics, and the Nervous System, Advances in Neurobiology, Springer Publishers 3rd Ed 2013.

    - Rachidi M., Tetaria C., Lopes C. (2011). “Cell cycle alteration in Down syndrome”. In Berhardt LV. (Ed.), Advances in Medicine and Biology, 2011, Vol. 20. Nova Science Publisher.

    - Rachidi, M. and Lopes, C. (2010). Molecular and Cellular Mechanisms Elucidating the Neurocognitive Basis of Functional Impairments Associated with Intellectual Disability in Down syndrome.
    American Journal of  Intellectual Developmental Disabilities, 2010; 115., 83-112.

    - Rachidi, M. and Lopes, C. (2010). Cell Cycle Alteration in Down syndrome.
    International Journal of Medical and Biological Frontiers, 2010, Volume 16, Issue 3/4,  Nova Science Publishers.

    - Rachidi, M. and Lopes, C. (2009). Gene Expression Regulation in Down syndrome: Dosage Imbalance Effects at Transcriptome and Proteome Levels. Handbook of Down syndrome Research, Edition Nova Science Publishers, Inc., 2009, 55-87

    - Rachidi, M., Delezoide, A-L., Delabar, J.M. and Lopes, C. (2009). A quantitative assessment of gene [removed]QAGE) reveals differential overexpression of DOPEY2, a candidate gene for mental retardation, in Down syndrome brain regions.
    International Journal of Developmental Neuroscience, 2009, 27, 393-398.

    - Rachidi, M., Tetaria, C., and Lopes, C. (2008). Trisomy of Human Chromosome 21 and Cell Cycle Control. In Leroy NH., Fournier NT. (Eds.): Cell Cycle Control: New Research, Nova Science Publishers, Inc., 2008, 159-189.

    - Rachidi, M. and Lopes, C. (2008). Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways.
    European Journal of Paediatric Neurology, 2008, 12, 168-182.

    - Rachidi, M. and Lopes, C. (2008). Molecular Mechanisms of Mental Retardation in Down syndrome. Rachidi, M. and Lopes, C. (Editors), Nova Biomedical Book: Edition Nova Science Publishers, Inc., 2008, pp 1-94.

    - Rachidi, M., Lopes, C.; C Vayssettes, D J. Smith, E M Rubin, J.M Delabar. (2007). New Cerebellar Phenotypes in YAC Transgenic mouse in vivo Library of Human Down syndrome Critical Region 1.
    Biochemical Biophysical Research Communications, 2007, 364(3), 488-494.

    - Rachidi, M. and Lopes, C. (2007). Molecular Mechanisms of Mental Retardation in Down Syndrome. In Carson MI. (Ed.): Focus on Mental Retardation Research. Nova Science Publishers, Inc. 2007, pp. 77-134.

    - Rachidi, M. and Lopes, C. (2007). Mental retardation in Down syndrome: From gene dosage imbalance to molecular and cellular mechanisms.
    Neuroscience Research, 2007, 59(4), 349-369.

    - Rachidi, M. and Lopes, C. (2006). Differential transcription of Barhl1 homeobox gene in restricted functional domains of the central nervous system suggests a role in brain patterning.
    International Journal of Developmental Neuroscience, 2006, 24(1), 35-44.

    - Rachidi, M., Lopes, C., Delezoide, A.L. and Delabar, J.M. (2006). C21orf5, a human candidate gene for brain abnormalities and mental retardation in Down Syndrome.
    Cytogenetics and Genome Research, 2006, 112(1-2), 16-22.

    - Lopes, C., Delezoide, A.L., Delabar, J.M. and Rachidi, M. (2006). BARHL1 homeogene, the human ortholog of the mouse Barhl1 involved in cerebellum development, shows regional and cellular specificities in restricted domains of developing human central nervous system.
    Biochemical Biophysical Research Communications, 2006, 339, 296-304.

    - Rachidi, M., Lopes, C., Costantine, M. and Delabar J.M. (2005). C21orf5, a new member of dopey family involved in morphogenesis, could participate to neurological alterations and mental retardation in Down syndrome.
    DNA Research, 2005, 12, 203-210.

    - Rachidi, M., Lopes, C., Charron, G., Delezoide, AL., Paly, E., Bloch, B. and Delabar, JM. (2005). Spatial and temporal localization during embryonic and fetal human development of the transcription factor SIM2 in brain regions altered in Down syndrome.
    International Journal of Developmental Neuroscience, 2005, 23, 475-484.

    - Rachidi, M., Lopes, C., Benichou, J.C., Hellio, R. and Maisonhaute, C. (2005). Virus-like particle formation in Drosophila melanogaster germ cells suggests a complex translational regulation of the retrotransposon cycle and new mechanisms inhibiting transposition.
    Cytogenetics and Genome Research, 2005, 111(1), 88-95.

    - Lopes, C., Chettouh, Z., Delabar, J.M. and Rachidi, M. (2003). The differentially expressed C21orf5 gene in the medial temporal-lobe system could play a role in mental retardation in Down syndrome and transgenic mice. Biochemical Biophysical Research Communications, 2003, 305, 915-924.

    - Takamatsu, Y., *Nakagoshi, H., *Rachidi, M., Lopes, C. Nishida, Y. and Ohsako, S. (2002). Characterization of the dCaMKII-GAL4 driver line whose expression is controlled by the. Drosophila Ca²+/calmodulin dependent protein kinase II promoter.
    Cell Tissue Research., 2002, 310(2), 237-252.

    - Lopes, C., Gassanova, S., Delabar, J.M. and Rachidi, M. (2001). The CASK/Lin-2 Drosophila Homologue, Camguk, Could Play a Role in Epithelial Patterning and in Neuronal Targeting.
    Biochemical Biophysical Research Communications, 2001, 284(4), 1004-1010.

    - Lopes, C., Rachidi, M., Charron, G., Chamoun, Z., Dahmane, N., Toyama, K., Chettouh, Z., Vekemans, M., Bloch, B., Delezoide, A.L. and Delabar, JM. (2001). Conservation of the CNS expression pattern of new genes from the Down syndrome chromosomal region-1: human genes and their murine orthologs.
    Cytogenetics and Cell Genetics, 2001, 92(1-2), 1-22.

    - Rachidi, M., Lopes, C., Gassanova, S., Sinet, P.M., Vekemans, M., Attie, T., Delezoide, A.L. and Delabar, J.M. (2000). Regional and cellular specificity of TPRD, the tetratricopeptide Down Syndrome gene, during embryonic development.
    Mechanisms of Development, 2000, 93(1-2), 189-193.

    - Delabar, J.M., Rachidi, M., Lopes, C., Charron, G., Chamoun, Z, Dahmane, N., Toyama, K., Chettouh, Z., Vekemans, M., Bloch, B. and Delezoide, A.L. (2000). Conservation of the CNS expression pattern of new genes from the Down Syndrome Chromosomal Region-1: Human genes and their Murine orthologs.
    European Journal Neuroscience, 2000, 12(Supp 11), 297.

    - Orti, R., Rachidi, M., Viallard, F., Toyama, K., Lopes, C., Taudien, S., Rosenthal, A., Sinet, P.M. and Delabar, J.M. (2000). Characterisation of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and its murine ortholog.
    Genomics, 2000, 64(2), 203-210.

    - Rahmani, Z., Lopes, C., Rachidi, M. and Delabar, J.M. (1999). Expression of the mnb (dyrk) protein in adult and embryonic mouse tissues.
    European Journal of Human Genetics, 1999, 7(Supp.1), 111.

    - Rachidi, M., Lopes, C., Takamatsu, Y., Ohsako, S., Benichou J.C. and Delabar, J.M. (1999). Dynamic expression pattern of Ca2+/calmodulin-dependent protein kinase II gene in the central nervous system of Drosophila throughout development.
    Biochemical Biophysical Research Communications, 1999, 260(3), 707-711.

    - Lopes, C., Rachidi, M., Gassanova, S., Sinet, P.M. and Delabar, J.M. (1999). Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1.
    Mechanisms of Development, 1999, 84(1-2), 189-193.

    - Rahmani, Z., Lopes, C., Rachidi, M. and Delabar, J.M. (1998). Expression of the Mnb (dyrk) protein in adult and embryonic mouse tissues.
    Biochemical Biophysical Research Communications,  1998, 253(2), 514-518.

    - Rachidi, M., Lopes, C. and Benichou, J.C. (1997). Genetical analysis of visual system disorganizer (vid), a new gene involved in normal development of eye and optic lobe of the brain in Drosophila melanogaster. 
    Genetica, 1997, 99, 31-45.

    - Rachidi, M., Lopes, C., Benichou, J.C. and Rouyer, F. (1997). Analyse of period circadian expression in the Drosophila head by in situ hybridization. Journal of Neurogenetics, 1997, 11, 255-263.

    - Rouyer, F., Rachidi, M., Pikielny, C. and Rosbash, M. (1997). A new gene encoding a putative transcritpion factor regulated by the Drosophila circadian clock.
    EMBO Journal, 1997, 16(13), 3944-3954.

    - Haoudi, A., Rachidi, M., Kim, M.H., Champion, S., Best-Belpomme, M. and Maisonhaute, C. (1997). Developmental expression analysis of the 1731 retrotransposon reveals an enhancement of Gag-Pol frameshifting in males of Drosophila melanogaster.
    Gene, 1997, 196 (1-2), 83-93.

    - Fassouane, A., Rachidi, M., Rouffaud, M.A., El-Abbouyi, A. and Nguyen, V.H. (1995). In vitro antifungal activity of Bacillus licheniformis FSJ-2 products against dermatophytes.
    Journal of Mycology and Medicine, 1995, 5, 244-248.

    - Rachidi, M. (1993). The Drosophila visual system: An elaborated building and a powerful model for developmental studies. Biomatec Journal, 1993, 4-5, 2-8.

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    Kranthi Kolli
    Post-doctoral Research Associate
    Department of Radiology
    Weill Cornell Medical College
    USA
    krk2009@med.cornell.edu
    ABSE

    Biography:

    My research focuses on establishing the clinical applicability of two new diagnostic parameters (to detect coronary artery disease) using a set of bench-top experiments, computational analysis, pre-clinical and clinical trials in our research group. These proposed diagnostic parameters based on fluid dynamic principles, pressure drop coefficient and lesion flow coefficient, have the potential to make a real paradigm shift in clinical decision making related to cardiovascular intervention. As part of my research involving pre-clinical and clinical trials I had collaborated with clinicians and scientists at College of Medicine, University of Cincinnati and at Cincinnati Children's Hospital and Medical Center. Preliminary results from these studies have concluded the clinical applicability of these parameters to distinguish between stenoses of various severity.
    More recently, at Weill Cornell Medical College, I am working on using 3D printing, machine learning and computational fluid dynamics to predict and prevent coronary artery disease from non-invasive CCTA imaging data.

    Research Interest: 3D printing, Computational fluid dynamics, clinical radiology, non-invasive CCTA scanning, machine learning, interventional cardiology, applied mathematics, bio-heat transfer

    List of Publications:

    1. Al'Aref SJ, Anchouche K, Singh G, Slomka PJ, Kolli KK, Kumar A, Pandey M, Maliakal G, van Rosendael AR, Beecy AN, Berman DS, Leipsic J, Nieman K, Andreini D, Pontone G, Schoepf UJ, Shaw LJ, Chang HJ, Narula J, Bax JJ, Guan Y, Min JK. Clinical applications of machine learning in cardiovascular disease and its relevance to cardiac imaging. Eur Heart J. 2018. Epub 2018/07/31. doi: 10.1093/eurheartj/ehy404. PubMed PMID: 30060039. Available from: https://www.ncbi.nlm.nih.gov/pubmed/30060039.

    2. Kolli KK, Min JK. Image-based computational fluid dynamic analysis for surgical planning of sequential grafts in coronary artery bypass grafting. Accepted as Contributed full paper for publication in Conference Proceedings for IEEE Engineering in Medicine and Biology Society Conference. 2018. [Accepted]

    3. van Rosendael AR, Maliakal G, Kolli KK, Beecy A, Al'Aref SJ, Dwivedi A, Singh G, Panday M, Kumar A, Ma X, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, Pontone G, Raff GL, Rubinshtein R, Shaw LJ, Villines TC, Gransar H, Lu Y, Jones EC, Pena JM, Lin FY, Min JK. Maximization of the usage of coronary CTA derived plaque information using a machine learning based algorithm to improve risk stratification; insights from the CONFIRM registry. J Cardiovasc Comput Tomogr. 2018;12(3):204-9. Epub 2018/05/14. doi: 10.1016/j.jcct.2018.04.011. PubMed PMID: 29753765. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29753765.

    4. Singh G, Al'Aref SJ, Van Assen M, Kim TS, van Rosendael A, Kolli KK, Dwivedi A, Maliakal G, Pandey M, Wang J, Do V, Gummalla M, De Cecco CN, Min JK. Machine learning in cardiac CT: Basic concepts and contemporary data. J Cardiovasc Comput Tomogr. 2018; 12(3):192-201. Epub 2018/05/15. doi: 10.1016/j.jcct.2018.04.010. PubMed PMID: 29754806. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29754806.

    5. Beecy AN, Chang Q, Anchouche K, Baskaran L, Elmore K, Kolli KK, Wang H, Al'Aref S, Pena JM, Knight-Greenfield A, Patel P, Sun P, Zhang T, Kamel H, Gupta A, Min JK. A Novel Deep Learning Approach for Automated Diagnosis of Acute Ischemic Infarction on Computed Tomography. JACC Cardiovascular imaging. 2018. Epub 2018/05/21. doi: 10.1016/j.jcmg.2018.03.012. PubMed PMID: 29778866. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29778866.

    6. Peelukhana SV, Banerjee R, van de Hoef TP, Kolli KK, Effat M, Helmy T, Leesar M, Kerr H, Piek JJ, Succop P, Back L, Arif I. Evaluation of lesion flow coefficient for the detection of coronary artery disease in patient groups from two academic medical centers. Cardiovascular Revascularization
    Kranthi Kolli 6 10/05/2018Medicine. 2018;19(3 Pt B):348-54. Epub 2017/10/19. doi: 10.1016/j.carrev.2017.08.018. PubMed PMID: 29037762. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29037762.

    7. Han D, Starikov A, Xiong G, Hartaigh B, Granser H, Kolli KK, Lee J, Rizvi A, Baskaran L, Schulman-Marcus J, Lin FY, Min JK. Relationship between endothelial wall shear stress and high-risk atherosclerotic plaque characteristic for identification of coronary lesions that cause ischemia: A direct comparison to fractional flow reserve. Journal of the American Heart Association. 2016; 5(12). doi: 10.1161/JAHA.116.004186. PubmMed PMID: 27993831. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27993831

    8. Kolli KK, Min JK, Ha S, Soohoo H, Xiong G. Effect of Varying Hemodynamic and Vascular Conditions on Fractional Flow Reserve: An In Vitro Study. Journal of the American Heart Association. 2016;5(7). doi: 10.1161/JAHA.116.003634. PubMed PMID: 27364988. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27364988.

    9. Kolli KK, van de Hoef TP, Effat MA, Banerjee RK, Peelukhana SV, Succop P, Leesar MA, Imran A, Piek JJ, Helmy TA. Diagnostic cutoff for pressure drop coefficient in relation to fractional flow reserve and coronary flow reserve: A patient-level analysis. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2016;87(2):273-82. doi: 10.1002/ccd.26063. PubMed PMID: 26424295. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26424295.

    10. Peelukhana SV, Effat M, Kolli KK, Arif I, Helmy T, Leesar M, Kerr H, Back LH, Banerjee R. Lesion flow coefficient: a combined anatomical and functional parameter for detection of coronary artery disease--a clinical study. The Journal of invasive cardiology. 2015;27(1):54-64. PubMed PMID: 25589702. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25589702.

    11. Peelukhana SV, Banerjee R, Kolli KK, Fernandez-Ulloa M, Arif I, Effat M, Helmy T, Kerr H. Benefit of ECG-gated rest and stress N-13 cardiac PET imaging for quantification of LVEF in ischemic patients. Nuclear medicine communications. 2015;36(10):986-98. doi: 10.1097/MNM.0000000000000352. PubMed PMID: 26225941. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26225941.

    12. Peelukhana SV, Kolli KK, Leesar MA, Effat MA, Helmy TA, Arif I, Schneeberger EW, Succop P, Banerjee RK. Effect of myocardial contractility on hemodynamic end points under concomitant microvascular disease in a porcine model. Heart and vessels. 2014;29(1):97-109. doi: 10.1007/s00380-013-0355-9. PubMed PMID: 23624760. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23624760.

    13. Peelukhana SV, Kerr H, Kolli KK, Fernandez-Ulloa M, Gerson M, Effat M, Arif I, Helmy T, Banerjee R. Benefit of cardiac N-13 PET CFR for combined anatomical and functional diagnosis of ischemic coronary artery disease: a pilot study. Annals of nuclear medicine. 2014;28(8):746-60. doi: 10.1007/s12149-014-0869-y. PubMed PMID: 24950752. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24950752.

    14. Kolli KK, Helmy TA, Peelukhana SV, Arif I, Leesar MA, Back LH, Banerjee RK, Effat MA. Functional diagnosis of coronary stenoses using pressure drop coefficient: a pilot study in humans. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2014;83(3):377-85. doi: 10.1002/ccd.25085. PubMed PMID: 23785016. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23785016.

    15. Kolli KK, Effat MA, Peelukhana SV, Succop P, Back LH, Leesar MA, Helmy TA, Imran A, Banerjee RK. Hyperemia-free delineation of epicardial and microvascular impairments using a basal index. Annals of biomedical engineering. 2014;42(8):1681-90. doi: 10.1007/s10439-014-1020-x. PubMed PMID: 24806315. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24806315.
    Kranthi Kolli 7 10/05/2018

    16. Kolli KK, Arif I, Peelukhana SV, Succop P, Back LH, Helmy TA, Leesar MA, Effat MA, Banerjee RK. Diagnostic performance of pressure drop coefficient in relation to fractional flow reserve and coronary flow reserve. The Journal of invasive cardiology. 2014;26(5):188-95. PubMed PMID: 24791716. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24791716.

    17. Kolli KK, Paul AK, Back LH, Effat MA, Banerjee RK. Optimization of balloon obstruction for simulating equivalent pressure drop in physiological stenoses. Biorheology. 2013;50(5-6):257-68. doi: 10.3233/BIR-130640. PubMed PMID: 24398608. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24398608.

    18. Peelukhana SV, Banerjee RK, Kolli KK, Effat MA, Helmy TA, Leesar MA, Schneeberger EW, Succop P, Gottliebson W, Irif A. Effect of heart rate on hemodynamic endpoints under concomitant microvascular disease in a porcine model. American journal of physiology Heart and circulatory physiology. 2012;302(8):H1563-73. doi: 10.1152/ajpheart.01042.2011. PubMed PMID: 22287585. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22287585.

    19. Kolli KK, Banerjee RK, Peelukhana SV, Effat MA, Leesar MA, Arif I, Schneeberger EW, Succop P, Gottliebson WM, Helmy TA. Effect of changes in contractility on pressure drop coefficient and fractional flow reserve in a porcine model. The Journal of invasive cardiology. 2012;24(1):6-12. PubMed PMID: 22210582. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22210582.

    20. Rajabi-Jaghargh E, Kolli KK, Back LH, Banerjee RK. Effect of guidewire on contribution of loss due to momentum change and viscous loss to the translesional pressure drop across coronary artery stenosis: an analytical approach. Biomedical engineering online. 2011;10:51. doi: 10.1186/1475-925X-10-51. PubMed PMID: 21658283; PMCID: 3141581. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21658283.

    21. Kolli KK, Banerjee RK, Peelukhana SV, Helmy TA, Leesar MA, Arif I, Schneeberger EW, Hand D, Succop P, Gottliebson WM, Effat MA. Influence of heart rate on fractional flow reserve, pressure drop coefficient, and lesion flow coefficient for epicardial coronary stenosis in a porcine model. American journal of physiology Heart and circulatory physiology. 2011;300(1):H382-7. doi: 10.1152/ajpheart.00412.2010. PubMed PMID: 20935151. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20935151.


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    Blue Cameron L
    Department of Science and Technology
    Geneva University
    Switzerland
    lbluecameron@gmail.com
    ABSE

    Research Interest: Cell and tissue engineering

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    Francesco D Angelo
    Angeglantoni Life Science
    Italy
    francescodangelo@hotmail.it
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    Research Interest: Stem cells and Regenerative Medicine, Tissue Regeneration, Tissue Engineering Stem Cells Biology and Differentiation, Stem cells biomaterials interaction, Mechanotransduction

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    Herng-Hua Chang
    Assistant Professor
    Department of Engineering Science & Ocean Engineering
    National Taiwan University
    Taiwan
    herbertchang@ntu.edu.tw
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    Kang Wei
    Department of Biomedical Engineering
    Ohio State University
    USA
    wei.179@osu.edu
    ABSE

    Research Interest: Biophotonics, BioMEMS, Optofluidics, Surface Wettability, Drug Delivery

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    Pei Feng
    College of Mechanical and Electrical Engineering
    Central South University
    China
    fengpei@csu.edu.cn
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    Research Interest:  Biofabrication, Selective laser sintering, Nanotechnology, 3D Printing Biomaterials, Tissue Engineering

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    Wei Meng
    Department of Genetic Engineering
    Southern Medical University
    PR China
    mengwei_126@126.com
    ABSE

    Research Interest: Basic experiment skills in molecular and cell biology, immunology and zoology as follows: Molecular biology:Regular skills of molecular biology;plasmid construction, including shRNA and overexpression, GFP fusion protein, nucleic acid extraction, purification.  Biochemistry: protein expression analysis, including western blotting, immunoprecipitation and quantitative real-time RT-PCR; E.coli expressionsystem, soluble and insoluble protein purification.  Cell biology: Mammalian cell culture; plasmid transfection; development of stable transfected cell lines; immunohistochemistry; immunocytochemistry.   Others: Basic animal, especially mouse and rat handling skills;drosophila culture; familiar with ordinary operation of laser scanning confocal microscopy  (Leica,Zeiss,Olympus), fluorescence microscopy, fluorescence spectrometer;familiar with ordinary statistic and bioinformatical softwares.

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    Sophie Laurent
    Assistant Professor
    Department of General, Organic and Biomedical Chemistry
    University of Mons
    Belgium
    Sophie.LAURENT@umons.ac.be
    ABSE

    Research Interest: Development of new lanthanide complexes for MRI and optical imaging: synthesis, purification (HPLC, flash chromatography) and physicochemical characterization (NMR spectroscopy, mass spectrometry, luminescence, UV-visible, FTIR).  

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    Joseph An-Cheng Shiau
    Department of Medical Physics
    Taiwan
    shiau158@ms22.hinet.net
    ABSE

    Research Interest: Medical Physics, Health physics, Radiation detection, Technique of Radiation Therapy, Treatment Planning in Radiation Therapy.

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