Dr. Wei Wu is an Associate Professor and Associate Department Chair in the Department of Toxicology at Nanjing Medical University, China, where he received his Ph.D. in Toxicology in 2012. He was a guest researcher at the National Institute of Environmental Health Sciences (NIEHS) between 2017 and 2018.
He is a member of different national and international societies in the fields of human reproduction and toxicology, and has received awards from many national societies for the originality and quality of his projects. He has a wide range of teaching and consulting experience, including in the area of toxicology. His research interests include epigenetic mechanisms of transgenerational effects of male infertility induced by endocrine disrupting chemicals, environmental exposure, and male reproductive health, genetic and epigenetic risk factors of male infertility and abnormal fetal growth.
Prof. Wu has authored 72 peer-reviewed papers in international journals such as EBioMedicine, Clinical Epigenetics, Environment International, Toxicological Sciences, Scientific Reports, Human Reproduction, and Molecular Human Reproduction. He has edited four books and collaborated on ten books, 11 patents and in the organization of three international conferences. He is a reviewer of 62 journals. Prof. Wu serves as the Editor-in-Chief of an international scientific journal International Journal of Sexual Health and Reproductive Health Care, Executive Editor of Annals of Molecular and Genetic Medicine, Associate Editor of the JSM Invitro Fertilization, and editor of many other journals including Scientific Reports and Medicine.
Research Interest: Dr. Wei Wu research interests includes male reproductive health, reproductive toxicology, pregnancy complications, abnormal birth outcomes, epigenetics and fetal growth, genetics, polymorphism, reproductive epidemiology, and environmental epidemiology.
1） Major Project of Natural Science Research in Jiangsu Province Colleges and Universities in 2020 (20KJA330001): the role of miR-206/Ehhadh in the intergenerational inheritance of spermatogenesis from exposure to pregnancy DBP and its mechanism ,2021/1-2023/12, ￥150,000.
2） Medical Research Project of Jiangsu Health and Health Commission (Z2019010): study on the mechanism of transgenerational inheritance of spermatogenesis induced by metabolic pathway changes in intrauterine DBP exposure 2020/1-2022/12, ￥10,000.
3） National key research and development project: The establishment and basic research for application of China Assisted reproductive birth cohort population and the offspring cohort of the Chinese population. 2016/7-2021/6, ￥280,900.
4） National Natural Science Foundation of China (81673217): The study of role and molecular mechanisms of the DSTF1/miR-125-3p/Fstl3 pathway in the transgenerational spermatogenic failure caused by prenatal DBP exposure. 2017/1-2020/12, ￥600,000.
5） China Postdoctoral Science Foundation (2015T80571): The role and molecular mechanisms of human miR-483-3p in the BP-3 induced fetal macrosomia. 2015/7-2017/6, ￥150,000.
6） National Natural Science Foundation of China (81302457): Effect and mechanism of miR-17-92 gene cluster in spermatogenic failure induced by genistein exposure. 2014/1-2016/12, ￥240,000.
7） Jiangsu Natural Science Foundation (BK20130894): The role and molecular mechanisms of miR-200s family in spermatogenic failure induced by genistein exposure. 2013/7-2016/6, ￥200,000.
8） China Postdoctoral Science Foundation (2013M531388): The role and molecular mechanism of imprinted lncRNA-H19 in fetal growth restriction. 2013/3-2015/2, ￥50,000.
9） Science and Technology Development Fund Key Project of Nanjing Medical University (2012NJMU002): Environment and epigenetics risk factors and their interactions in spermatogenic failure. 2012/12-2014/12, ￥30,000.
List of Publications:
1） Guan Q, Chen S, Wang B, Dou X, Lu Y, Liang J, Ni R, Yang C, Wang H, Baktash MB, Wu W, Wang X, Fu G, Xia Y. Effects of particulate matter exposure on semen quality: A retrospective cohort study. Ecotoxicol Environ Saf. 2020; 193:110319.
2） Yuan B, Wu W, Zhang H, Gu H, Guo D, Jiang J, Wang X. Adenomatous polyposis coli as a predictor of environmental chemical-induced transgenerational effects related to male infertility. J Biochem Mol Toxicol. 2019 Jul;33(7):e22331.
3） Tang Q, Gui J, Wu X, Wu W*. Downregulation of miR-424 in placenta is associated with severe preeclampsia. Pregnancy Hypertens. 2019; 17:109-112.
4） Tang Q, Pan F, Wu X, Nichols CE, Wang X, Xia Y, London SJ, Wu W*. Semen quality and cigarette smoking in a cohort of healthy fertile men. Environ Epidemiol. 2019; (32019)3:e055.
5） Han X, Wang Y, Chen T, Wilson MJ, Pan F, Wu X, Rui C, Chen D, Tang Q, Wu W*. Inhibition of progesterone biosynthesis induced by deca-brominated diphenyl ether (BDE-209) in mouse Leydig tumor cell (MLTC-1). Toxicol In Vitro. 2019; 60:383-388.
6） Guo D, Jiang H, Chen Y, Yang J, Fu Z, Li J, Han X, Wu X, Xia Y, Wang X, Chen L, Tang Q, Wu W*. Elevated microRNA-141-3p in placenta of non-diabetic macrosomia regulate trophoblast proliferation. EBioMedicine. 2018; 38:154-161. (Cover Article)
7） Tang Q, Pan F, Yang J, Fu Z, Lu Y, Wu X, Han X, Chen M, Lu C, Xia Y, Wang X, Wu W*. Idiopathic male infertility is strongly associated with aberrant DNA methylation of imprinted loci in sperm: a case-control study. Clin Epigenetics. 2018; 10(1):134.
8） Li J, Fu Z, Jiang H, Chen L, Wu X, Ding H, Xia Y, Wang X, Tang Q, Wu W*. IGF2-derived miR-483-3p contributes to macrosomia through regulating trophoblast proliferation by targeting RB1CC1. Mol Hum Reprod. 2018; 24(9):444-452.
9） Zhou R, Zhang Y, Du G, Han L, Zheng S, Liang J, Huang X, Qin Y, Wu W, Chen M, Wu D, Song L, Fu G, Lv S, Xia Y, Lu C, Wang X. Down-regulated let-7b-5p represses glycolysis metabolism by targeting AURKB in asthenozoospermia. Gene. 2018; 663:83-87.
10） Chen M, Ni C, Hu Y, Wang M, Liu L, Ji X, Chu H, Wu W, Lu C, Wang S, Wang S, Zhao L, Li Z, Zhu H, Wang J, Xia Y, Wang X. Meta-analysis on the effectiveness of team-based learning on medical education in China. BMC Med Educ. 2018;18(1):77.
11） Han Y, Ji Y, Kang S, Dong T, Zhou Z, Zhang Y, Chen M, Wu W, Tang Q, Chen T, Wang Y, Xia Y. Effects of particulate matter exposure during pregnancy on birth weight: A retrospective cohort study in Suzhou, China. Sci Total Environ. 2018; 615:369-374.
12） Yuan B, Wu W*, Chen M, Gu H, Tang Q, Guo D, Chen T, Chen Y, Lu C, Song L, Xia Y, Chen D, Rehan V, Sha J, Wang X*. Metabolomics reveals a role of betaine in prenatal DBP exposure-induced epigenetic transgenerational failure of spermatogenesis in rats. Toxicol Sci. 2017; 158 (2): 356-366. (Cover Article)
13） Tang Q, Chen Y, Wu W*, Ding H, Xia Y, Chen D, Wang X. Idiopathic male infertility and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking. Sci Rep. 2017; 7(1):11219.
14） Wang L, Hu W, Guan Q, Du G, Chen T, Wu W, Wang Y, Wang X, Xia Y. The association between cooking oil fume exposure during pregnancy and birth weight: A prospective mother-child cohort study. Sci Total Environ. 2017; 612:822-830.
15） Qiao S, Wu W (co-first author), Chen M, Tang Q, Xia Y, Jia W, Wang X. Seminal plasma metabolomics approach for the diagnosis of unexplained male infertility. PLoS One. 2017; 12(8):e0181115.
16） Hu W, Chen M, Ji J, Qin Y, Zhang F, Xu M, Wu W, Du G, Wu D, Han X, Jin L, Xia Y, Lu C, Wang X. Interaction between Y chromosome haplogroup O3* and 4-n-octylphenol exposure reduces the susceptibility to spermatogenic impairment in Han Chinese. Ecotoxicol Environ Saf. 2017; 144:450-455.
17） Pan L, Liu Q, Li J, Wu W, Wang X, Zhao D, Ma J. Association of the VDAC3 gene polymorphism with sperm count in Han-Chinese population with idiopathic male infertility. Oncotarget. 2017; 8(28):45242-45248.
18） Chang C, Chen M, Gao J, Luo J, Wu K, Dong T, Zhou K, He X, Hu W, Wu W, Lu C, Hang B, Meeker JD, Wang X, Xia Y. Current pesticide profiles in blood serum of adults in Jiangsu Province of China and a comparison with other countries. Environ Int. 2017; 102:213-222.
19） Gu H, Wu W*, Yuan B, Tang Q, Guo D, Chen Y, Xia Y, Hu L, Chen D, Sha J, Wang X. Genistein up-regulates miR-20a to disrupt spermatogenesis via targeting Limk1. Oncotarget. 2017; 8(35):58728-58737.
20） Guo D, Wu W*, Tang Q, Qiao S, Chen Y, Chen M, Teng M, Lu C, Ding H, Xia Y, Hu L, Chen D, Sha J, Wang X. The impact of BMI on sperm parameters and the metabolite changes of seminal plasma concomitantly. Oncotarget. 2017; 8(30):48619-48634.
21） Chen T, Xu J, Liu G, Liu H, Chen M, Qin Y, Wu W, Xia Y, Ji C, Guo X, Wen J, Wang X. Genetic variants in PTPRD and risk of gestational diabetes mellitus. Oncotarget. 2016; 7(46):76101-76107.
22） Ji J, Qin Y, Zhou R, Zang R, Huang Z, Zhang Y, Chen M, Wu W, Song L, Ling X, Shen H, Hu Z, Xia Y, Lu C, Wang X. X chromosome-wide identification of SNVs in microRNA genes and non-obstructive azoospermia risk in han chinese population. Oncotarget. 2016; 7(31):49122-49129.
23） Chang J, Pan F, Tang Q, Wu W*, Chen M, Lu C, Ding H, Hu L, Chen D, Xia Y, Wang X. eNOS gene T786C, G894T and 4a4b polymorphisms and male infertility susceptibility: a meta-analysis. Andrologia. 2016; 49(4).
24） Hu W, Chen M, Wu W*, Lu J, Zhao D, Pan F, Lu C, Xia Y, Hu L, Chen D, Sha J, Wang X. Gene-gene and gene-environment interactions on risk of male infertility: Focus on the metabolites. Environ Int. 2016; 91:188-195.
25） Pan B, Li R, Chen Y, Tang Q, Wu W*, Chen L, Lu C, Pan F, Ding H, Xia Y, Hu L, Chen D, Sha J, Wang X. Genetic Association Between Androgen Receptor Gene CAG Repeat Length Polymorphism and Male Infertility: A Meta-Analysis. Medicine (Baltimore). 2016; 95(10):e2878.
26） Yuan B, Gu H, Xu B, Tang Q, Wu W*, Ji X, Xia Y, Hu L, Chen D, Wang X. Effects of Gold Nanorods on Imprinted Genes Expression in TM-4 Sertoli Cells. Int J Environ Res Public Health. 2016; 13(3). pii: E271.
27） Lu J, Gu H, Tang Q, Wu W*, Yuan B, Guo D, Wei Y, Sun H, Xia Y, Ding H, Hu L, Chen D, Sha J, Wang X. Common SNP in hsa-miR-196a-2 increases hsa-miR-196a-5p expression and predisposes to idiopathic male infertility in Chinese Han population. Sci Rep. 2016; 6:19825.
28） Zhou R, Wang R, Qin Y, Ji J, Xu M, Wu W, Chen M, Wu D, Song L, Shen H, Sha J, Miao D, Hu Z, Xia Y, Lu C, Wang X. Mitochondria-related miR-151a-5p reduces cellular ATP production by targeting CYTB in asthenozoospermia. Sci Rep. 2015; 5:17743.
29） Li J, Chen L, Tang Q, Wu W*, Gu H, Liu L, Wu J, Jiang H, Ding H, Xia Y, Chen D, Hu Y, Wang X. The role, mechanism and potentially novel biomarker of microRNA-17-92 cluster in macrosomia. Sci Rep. 2015; 5:17212.
30） Ji J, Qin Y, Ren J, Lu C, Wang R, Dai X, Zhou R, Huang Z, Xu M, Chen M, Wu W, Song L, Shen H, Hu Z, Miao D, Xia Y, Wang X. Mitochondria-related miR-141-3p contributes to mitochondrial dysfunction in HFD-induced obesity by inhibiting PTEN. Sci Rep. 2015; 5:16262.
31） Ju R, Wu W (co-first author), Tang Q, Wu D, Xia Y, Wu J, Wang X. Association Analysis between the Polymorphisms of HSD11B1 and H6PD and Risk of Polycystic Ovary Syndrome in Chinese Population. PLoS One. 2015; 10(10):e0140326.
32） Lu C, Xu M, Wang R, Qin Y, Ren J, Wu W, Song L, Wang S, Zhou Z, Shen H, Sha J, Hu Z, Xia Y, Miao D, Wang X. A genome-wide association study of mitochondrial DNA in Chinese men identifies two risk single nucleotide substitutions for idiopathic oligoasthenospermia. Mitochondrion. 2015; 24:87-92.
33） Tang W, Tang J, He J, Zhou Z, Qin Y, Qin J, Li B, Xu X, Geng Q, Jiang W, Wu W, Wang X, Xia Y. SLIT2/ROBO1-miR-218-1-RET/PLAG1: a new disease pathway involved in Hirschsprung's disease. J Cell Mol Med. 2015; 19(6):1197-207.
34） Ju R, Wu W (co-first author), Fei J, Qin Y, Tang Q, Wu D, Xia Y, Wu J, Wang X. Association analysis between the polymorphisms of HSD17B5 and HSD17B6 and risk of polycystic ovary syndrome in Chinese population. Eur J Endocrinol. 2015; 172(3):227-33.
35） Tang W, Li H, Tang J, Wu W, Qin J, Lei H, Cai P, Huo W, Li B, Rehan V, Xu X, Geng Q, Zhang H, Xia Y. Specific serum microRNA profile in the molecular diagnosis of Hirschsprung's disease. J Cell Mol Med. 2014; 18(8):1580-7.
36） Zhao M, Tang Q, Wu W (corresponding author), Xia Y, Chen D, Wang X. miR-20a contributes to endometriosis by regulating NTN4 expression. Mol Biol Rep. 2014; 41(9):5793-7.
37） Jiang H, Wu W (co-first author), Zhang M, Li J, Peng Y, Miao T, Zhu H, Xu G. Aberrant upregulation of miR-21 in placental tissues of macrosomia. J Perinatol. 2014; 34(9):658-63.
38） Zhang S, Tang Q, Wu W*, Yuan B, Lu C, Xia Y, Ding H, Hu L, Chen D, Sha J, Wang X. Association between DAZL polymorphisms and susceptibility to male infertility: systematic review with meta-analysis and trial sequential analysis. Sci Rep. 2014; 4:4642.
39） Qin Y, Ji J, Du G, Wu W, Dai J, Hu Z, Sha J, Hang B, Lu C, Xia Y, Wang X. Comprehensive pathway-based analysis identifies associations of BCL2, GNAO1 and CHD2 with non-obstructive azoospermia risk. Hum Reprod. 2014; 29(4):860-6.
40） Qin Y, Du G, Chen M, Hu W, Lu C, Wu W, Hang B, Zhou Z, Wang X, Xia Y. Combined effects of urinary phytoestrogens metabolites and polymorphisms in metabolic enzyme gene on idiopathic male infertility. Arch Toxicol. 2014; 88(8):1527-36.
41） Zhou Z, Qin J, Tang J, Li B, Geng Q, Jiang W, Wu W, Rehan V, Tang W, Xu X, Xia Y. Down-regulation of MeCP2 in Hirschsprung's disease. J Pediatr Surg. 2013; 48(10):2099-2105.
42） Tang W, Qin J, Tang J, Zhang H, Zhou Z, Li B, Geng Q, Wu W, Xia Y, Xu X. Aberrant reduction of MiR-141 increased CD47/CUL3 in Hirschsprung's disease. Cell Physiol Biochem. 2013; 32(6):1655-67.
43） Xu M, Qin Y, Qu J, Lu C, Wang Y, Wu W, Song L, Wang S, Chen F, Shen H, Sha J, Hu Z, Xia Y, Wang X. Evaluation of Five Candidate Genes from GWAS for Association with Oligozoospermia in a Han Chinese Population. PLoS One. 2013; 8(11):e80374.
44） Lu C, Xu M, Wang R, Qin Y, Wang Y, Wu W, Song L, Wang S, Shen H, Sha J, Miao D, Hu Z, Xia Y, Wang X. Pathogenic variants screening in five non-obstructive azoospermia-associated genes. Mol Hum Reprod. 2013; 20(2):178-83.
45） Tang Q, Li J, Zhang S, Yuan B, Sun H, Wu D, Lu C, Wu W (corresponding author), Xia Y, Ding H, Hu L, Chen D*, Sha J*, Wang X. GSTM1 and GSTT1 Null Polymorphisms and Childhood Acute Leukemia Risk: Evidence from 26 Case-Control Studies. PLoS One. 2013; 8(10):e78810.
46） Xu S, Xu P, Wu W, Ou Y, Xu J, Zhang G, Li J, Xu G. The biphasic expression pattern of miR-200a and E-cadherin in epithelial ovarian cancer and its correlation with clinicopathological features. Curr Pharm Des. 2014; 20(11):1888-95.
47） Wu W*, Lu J, Tang Q, Zhang S, Yuan B, Li J, Di Wu, Sun H, Lu C, Xia Y, Chen D, Sha J, Wang X. GSTM1 and GSTT1 null polymorphisms and male infertility risk: an updated meta-analysis encompassing 6934 subjects. Sci Rep. 2013; 3:2258.
48） Xu C, Song RJ, Yang J, Jiang B, Wang XL, Wu W, Zhang W. Klotho gene polymorphism of rs3752472 is associated with the risk of urinary calculi in the population of Han nationality in Eastern China. Gene. 2013; 526(2):494-7.
49） Lu C, Wang Y, Zhang F, Lu F, Xu M, Qin Y, Wu W, Li S, Song L, Yang S, Wu D, Jin L, Shen H, Sha J, Xia Y, Hu Z, Wang X. DAZ duplications confer the predisposition of Y chromosome haplogroup K* to non-obstructive azoospermia in Han Chinese populations. Hum Reprod. 2013; 28(9):2440-9.
50） Wu W*, Lu J, Chen D, Yuan B, Qin Y, Han X, Niu X, Xu B, Lu C, Xia Y, Sha J, Wang X. Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure. Gene. 2013; 524:197-202.
51） Tang W, Li B, Tang J, Liu K, Qin J, Wu W, Geng Q, Zhang J, Chen H, Xu X, Xia Y. Methylation analysis of EDNRB in human colon tissues of Hirschsprung's disease. Pediatr Surg Int. 2013; 29:683-8.
52） Lv Q, Lu J, Wu W, Sun H, Zhang J. Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with stroke risk based on a meta-analysis. Genet Mol Res. 2013; 12(4):6882-94.
53） Wu W, Qin Y, Li Z, Dong J, Dai J, Lu C, Guo X, Zhao Y, Zhu Y, Zhang W, Sha J, Shen H, Xia Y, Hu Z, Wang X. Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p. Hum Reprod. 2013; 28:1827-36.
54） Qin Y, Chen M, Wu W (co-first author), Xu B, Tang R, Chen X, Du G, Lu C, Meeker JD, Zhou Z, Xia Y, Wang X. Interactions between Urinary 4-tert-Octylphenol Levels and Metabolism Enzyme Gene Variants on Idiopathic Male Infertility. PLoS One. 2013; 8:e59398.
55） Tang Q, Wu W (co-first author), Xu X, Huang L, Gao Q, Chen H, Sun H, Xia Y, Sha J, Wang X, Chen D, Xu Q. miR-141 Contributes to Fetal Growth Restriction by Regulating PLAG1 Expression. PLoS One. 2013; 8:e58737.
56） Lu C, Xu M, Wang Y, Qin Y, Du G, Wu W, Han X, Ji C, Yang Y, Gu A, Xia Y, Song L, Wang S, Wang X. Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population. PLoS One. 2013; 8:e53443.
57） Xu S, Wu W (co-first author), Sun H, Lu J, Yuan B, Xia Y, Moor B, Marchal K, Wang X, Xu P, Cheng W. Association of the vascular endothelial growth factor gene polymorphisms (-460C/T, +405G/C, and +936T/C) with endometriosis: a meta-analysis. Ann Hum Genet. 2012; 76:464-471.
58） Chen M, Xu B, Ji W, Qiao S, Hu N, Hu Y, Wu W, Qiu L, Zhang R, Wang Y, Wang S, Zhou Z, Xia Y, Wang X. Bisphenol A Alters n-6 Fatty Acid Composition and Decreases Antioxidant Enzyme Levels in Rat Testes: A LC-QTOF-Based Metabolomics Study. PLoS One. 2012; 7:e44754.
59） Tang W, Li B, Xu X, Zhou Z, Wu W, Tang J, Qin J, Geng Q, Jiang W, Zhang J, Sha J, Xia Y, Wang X. Aberrant high expression of NRG1 gene in Hirschsprung disease. J Pediatr Surg. 2012; 47:1694-8.
60） Han X, Tang R, Chen X, Xu B, Qin Y, Wu W, Hu Y, Xu B, Song L, Xia Y, Wang X. 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) decreases progesterone synthesis through cAMP-PKA pathway and P450scc downregulation in mouse Leydig tumor cells. Toxicology. 2012; 302:44-50.
61） Zhao D, Wu W (co-first author), Xu B, Niu X, Cui H, Zhang Y, Wang Z, Wang X. Variants in the SRD5A2 gene are associated with quality of semen. Mol Med Report. 2012; 6:639-44.
62） Wu W, Hu Z, Qin Y, Dong J, Dai J, Lu C, Zhang W, Shen H, Xia Y, Wang X. Seminal plasma microRNAs: potential biomarkers for spermatogenesis status. Mol Hum Reprod. 2012; 18:489-97.
63） Wu W, Cai H, Sun H, Lu J, Zhao D, Qin Y, Han X, Niu X, Lu C, Xia Y, Wang S, De Moor B, Marchal K, Wang X. Follicle stimulating hormone receptor G-29A, 919A>G, 2039A>G polymorphism and the risk of male infertility: A meta-analysis. Gene. 2012; 505:388-92.
64） Qin Y, Xia Y, Wu W, Han X, Lu C, Ji G, Chen D, Wang H, Song L, Wang S, Wang X. Genetic variants in microRNA biogenesis pathway genes are associated with semen quality in a Han-Chinese population. Reprod Biomed Online. 2012; 24:454-61.
65） Shen O, Liu R, Wu W (co-first author), Yu L, Wang X. Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with male infertility: a meta-analysis. Ann Hum Genet. 2012; 76:25-32.
66） Lu C, Zhang F, Yang H, Xu M, Du G, Wu W, An Y, Qin Y, Ji G, Han X, Gu A, Xia Y, Song L, Wang S, Jin L, Wang X. Additional genomic duplications in AZFc underlie the b2/b3 deletion-associated risk of spermatogenic impairment in Han Chinese population. Hum Mol Genet. 2011; 20:4411-21.
67） Shen O, Wu W (co-first author), Du G, Liu R, Yu L, Sun H, Han X, Jiang Y, Shi W, Hu W, Song L, Xia Y, Wang S, Wang X. Thyroid Disruption by Di-n-Butyl Phthalate (DBP) and Mono-n-Butyl Phthalate (MBP) in Xenopus laevis. PLoS One. 2011; 6:e19159.
68） Wu W, Shen O, Qin Y, Lu J, Niu X, Zhou Z, Lu C, Xia Y, Song L, Wang S, Wang X. Methylenetetrahydrofolate reductase C677T polymorphism and the risk of male infertility: a meta-analysis. Int J Androl. 2012; 35:18-24.
69） Wu W, Shen O, Qin Y, Niu X, Lu C, Xia Y, Song L, Wang S, Wang X. Idiopathic Male Infertility Is Strongly Associated with Aberrant Promoter Methylation of Methylenetetrahydrofolate Reductase (MTHFR). PLoS One. 2010; 5: e13884.
70） Wu W, Lu C, Xia Y, Shen O, Ji G, Gu A, Song L, Wang X. Lack of association between DAZ gene methylation patterns and spermatogenic failure. Clin Chem Lab Med. 2010; 48: 355-60.
71） Shen O, Du G, Sun H, Wu W, Jiang Y, Song L, Wang X. Comparison of in vitro hormone activities of selected phthalates using reporter gene assays. Toxicol Lett. 2009; 191: 9-14.
72） Lu C, Zhang J, Li Y, Xia Y, Zhang F, Wu B, Wu W, Ji G, Gu A, Wang S, Jin L, Wang X. The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population. Hum Mol Genet. 2009; 18:1122-30.
Research Interest: Genomics of Brain Disorders; Epigenomics; Pharmacogenomics; Pharmacoepigenomics; Proteomics; Metabolomics; Nutrigenomics.
2015 – PhD, University of Cambridge, UK
2010 – MPhil, Newcastle University, UK
Research Interest: Molecular and cell biology, immunology, oncology
Grants: Russian Foundation of Basic Research
(#16-34-60213; #16-34-50250; #17-34-50167; # 19-54-10005)
List of Publications:
Articles and conference abstracts
1. Emil Bulatov, Regina Sayarova, Rimma Mingaleeva, Regina Miftakhova, Marina Gomzikova, Yuri Ignatyev, Alexey Petukhov, Pavel Davidovich, Albert Rizvanov and Nickolai Barlev / Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors // Cell Death Discovery, 4: 103 (2018)
(2018) Quartile Q1. Article.
2. Aleksei Titov, Alexey Petukhov, Alena Staliarova, Dmitriy Motorin, Emil Bulatov, Oleg Shuvalov, Surinder M. Soond, Mauro Piacentini, Gerry Melino, Andrey Zaritskey & Nickolai A. Barlev. The biological basis and clinical symptoms of CAR-T therapy-associated toxicites // Cell Death & Disease, 9, Article: 897 (2018)
Impact Factor = 6.187
(2018) Quartile Q2. Article.
3. Emil Bulatov, Aygul Valiullina, Regina Sayarova, Albert Rizvanov. Promising new therapeutic targets for regulation of inflammation and immunity: RING-type E3 ubiquitin ligases. Immunology Letters, 2018, 202, 44-51.
Impact Factor = 2.664
(2018) Quartile Q1. Article.
4. Bulatov E, Zagidullin A, Valiullina A, Sayarova R, Rizvanov A. Small molecule modulators of RING-type E3 ligases: MDM and cullin families as targets // Frontiers in Pharmacology, 2018, 9, Article 450.
Impact Factor = 4.439
(2018) Quartile Q1. Article.
5. Vafina, G., Zainutdinova, E., Bulatov, E., Filimonova, M.N. Endonuclease from gram-negative bacteria Serratia marcescens is as effective as pulmozyme in the hydrolysis of DNA in sputum. // Frontiers in Pharmacology, 2018, 9, Article 114.
Impact Factor = 4.439
Monography (27 pages).
6. Emil Bulatov. E3 ubiquitin ligases as targets for small molecule drug discovery: focus on Cullin RING family.
Глава в книге "Ubiquitin Proteasome System: A Review and Directions for Research". Hardcover edited collection (by selected invitation only). Nova Science Publishers, Inc., USA.
(2018) Quartile Q2. Conference thesis.
7. Glagoleva, I., Kudriaeva, A., Belogurov, A., Rizvanov, A. and Bulatov, E. / Effect of Nutlin-3a, RG-7112, Carfilzomib and MG-132 on accumulation of p53 in eukaryotic HEK293 cell line // European Journal of Clinical Investigation, 2018, 48, 100
Impact Factor = 2.707
(2017) Quartile Q1. Conference thesis.
8. A. Valiullina, M. Gomzikova, T. Khaibullin, A. Rizvanov & E. Bulatov. Regulation of p53-dependent genes expression in multiple sclerosis: the effect of MDM2 inhibitor Nutlin-3a. // European Journal of Clinical Investigation, 2017, 47 (Suppl. 1), 141–142
Impact Factor = 2.714
(2017) Quartile Q1. Conference thesis.
9. Aygul Kh. Valiullina, Marina Gomzikova, Ekaterina E. Garanina, Timur Khaibullin, Albert Rizvanov, and Emil Bulatov. Small Molecule p53-MDM2 Inhibitors As Potential Regulators of p53-Dependent Genes Expression in Multiple Sclerosis. // Blood, 2017, 130:4820
Impact Factor = 13.164
(2017) Quartile Q2. Conference thesis.
10. A. Valiullina, M. Gomzikova, T. Khaibullin, E. Garanina, E. Zmievskaya, A. Rizvanov, E. Bulatov. Effect of p53 activation on target gene expression and cytokine release in peripheral blood mononuclear cells. // Mol. Biol. Cell, 2017, vol. 28, no. 26, 545-546
Impact Factor = 3.685
(2016) Quartile Q2. Conference thesis.
11. Валиуллина, А.Х., Саярова, Р.М., Соловьева, В.В., Ризванов, А.А., Булатов Э.Р. Изучение роли белков р53 и MDM2 в качестве потенциальных регуляторов аутоиммунных процессов при рассеянном склерозе. // Acta Naturae, 2016, спецвыпуск, том 2, с. 66
Impact Factor = 1.770
(2016) Quartile Q3. Article.
12. Vafina G, Bulatov E, Zaynutdinova E, Filimonova M. A One-Step Protocol for Chromatographic Purification of Non-recombinant Exogenous Bacterial Enzyme: Nuclease of Serratia marcescens // BioNanoScience. - 2016. - Vol.6, Is.4. - P.335-337.
CiteScore (Scopus) = 1.48
(2016) Quartile Q3. Article.
13. Bulatov, E., Khaiboullina, S, dos Reis, H.J., Palotás, A., Venkataraman, K., Vijayalakshmi, M., Rizvanov, A. Ubiquitin-Proteasome System: Promising Therapeutic Targets in Autoimmune and Neurodegenerative Diseases // BioNanoScience. - 2016. - Vol.6, Is.4. - P.341-344.
CiteScore (Scopus) = 1.48
(2016) Quartile Q2. Conference thesis.
14. P. Davidovich, R. Sayarova, A. Valiullina, V. Solovyeva, M. Gomzikova, A. Smirnov, A. Rizvanov,
E. Bulatov. Novel isatin-Schiff base copper (II) complexes as potential p53-activating pro-apoptotic agents. // Mol. Biol. Cell, 2016, 27:25, 3947, 708.
Impact Factor = 4.037
(2016) Quartile Q1. Conference thesis.
15. Bulatov E., Valiullina A., Sayarova R., Rizvanov A. Inhibitors of MDM2 ubiquitin ligase as prospective modulators of autoimmunity // FEBS JOURNAL. - 2016. - Vol.283, Is.. - P.360-360.
Impact Factor = 4.237
(2015) Quartile Q1. Article.
16. Gadd, M. S., Bulatov, E. and Ciulli, A. Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases. // PLoS ONE 2015, 10, e0131218.
Impact Factor = 3.234
(2015) Quartile Q1. Article.
17. Bulatov, E. and Ciulli, A. Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation. // Biochem. J. 2015, 467, 365–386.
Impact Factor = 3.85
(2015) Quartile Q1. Article.
18. Bulatov, E., Martin, E. M., Chatterjee, S., Knebel, A., Shimamura, S., Konijnenberg, A., Johnson, C., Zinn, N., Grandi, P., Sobott, F., Ciulli, A. Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2). // J. Biol. Chem. 2015, 290, 4178–4191.
Impact Factor 2014 = 4.253
Article recommended by F1000Prime in Technical Advance category
1. Emil Bulatov. PhD Thesis. Interactions, assembly and fragment screening of the multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 ubiquitin ligase. University of Cambridge, UK, 2015.
2. Emil Bulatov. MPhil Thesis. Identification and Validation of a Series of P53-MDM2 and P53-MDMX Protein-protein Interaction Inhibitors. Newcastle University, UK, 2010.
Research Interest: Cancer treatment,) Tumor infiltrating lymphocytes ,immune cells, in tumor microenvironment,Caner stem cell,Myeloid-derived suppressor cells.
Research Interest: Programmed cell death, protein processing, intracellular communications, virus‐cell interactions, regulation of gene expression, RNAi, oxidative stress, aging, neurodegeneration, ophthalmology, cancer, regenerative medicine, personalized medicine, molecular markers, novel drug candidates.
Research Interest: Molecular cancer, pharmacogenetics, cell culture analysis.
Research Interest: Next-Generation Sequencing, target enrichment, diagnostics, hereditary disease, targeted therapy.
Research Interest: Cancer genetics and genomics, epigenetics, chromatin remodeling, signal transduction profiling, new drug discovery & development, complementary & alternative medicine, antibody/vaccine engineering.
Research Interest: Human genomics,Genetic epidemiology,Biostatistics,Evidence-based medicine.
Research Interest: organ pathology and effect of novel treatments in mouse model of lupus nephritis.
Research Interest: The effects and mechanisms of miRNA involved in cardiocascular system and cancers; The protective effects of Arachidonic acid Cytochrome P450 epoxygenase on cardiovascular system and relevant mechanisms; Cytochrome P450 and human cancers, focus on the roles of P450 epoxygenases on proliferation, metastasis and apoptosis of human cancers, also inhibition of human cancer growth by P450 epoxygenase inhibitors.
Research Interest: Molecular genetics, Atherosclerosis, Inflammation and Meta-analysis.
Research Interest: Gene therapy, non-viral gene delivery, inherited neuromuscular diseases,
peptide-based carriers, Duchenne muscular dystrophy, polyplex, transfection, siRNA delivery,
spinal muscular atrophy, genetic testing.
Research Interest: Newborn screening; Prenatal screening; Method development; Inborn Error of metabolism; Biochemical Genetics.
Research Interest: Science and Medicine.
I am a Professor of Medical Genetics in Turkey and clinical geneticist with specific interest in neurodevelopmental disorders. I have extensive experience in next-generation and high-throughput molecular genetics, with special focus on the use of homozygosity mapping, linkage analysis and whole-exome sequencing in recessive forms of structural and functional abnormalities of the brain. I have successfully detected rare and somatic genetic variant identification in diverse range of diseases using high-throughput and next-generation genomics approaches at Yale. In the last five years, I have published papers in Cell, Science, Nature, Nature Genetics and Neuron including one of the first successful applications of exome sequencing in the identification of genetic basis of recessive forms of structural and functional abnormalities of the brain.
I have served as a member of editorial boards, a reviewer in top-tier journals and conferences, and was invited to serve as a program committee member for international workshops and conferences as well. I established Medical Genetics Department and giving lectures to under and post graduate students, assisting in seminar groups or laboratories, and grading. Teaching activities are drawn from a diverse menu of lecture, laboratory, and seminar courses given at the undergraduate, graduate, and medical school level.
Research Interest: Mendelian Inherited Diseases, Cancer, Clinical Genetics
Number of publications: 41
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