Research Interest: Dr. Sun is currently exploring a new
therapeutic strategy to repress the transcriptional activation of human
oncogenes with small molecules capable of binding selectively to
non-canonical DNA structures formed within the promoter region of this
gene. Another aspect of his work focuses on understanding the chemical
and biological mechanisms of the antineoplastic, DNA-damaging natural
products to relate their chemical and biochemical properties to its
unique biological activity. Other aspects of our research focus on
understanding the molecular basis and the biological significance of
induction of DNA repair genes in human cancer cells in response to major
chemotherapeutics in order to identify potential targets appropriate
for new anticancer agents that will enhance the lethal activity of many
cancer chemotherapeutics
Research Interest: (1) Molecular biology and molecular
pathogenisis of animal herpesviruses,such as pseudorabies virus(PRV),
Bovine herpesvirus 1(BHV-1) and Bovine herpesvirus 5(BHV-5); (2)
Intracellular survival and replication of Brucella meltensis