Zhenyi Su

Designation:
Department:
Department of Biochemistry and Molecular Biology
University:
Southeast University
Country:
China
Email:
suzhenyi999@163.com
Journal Associated: International Journal of Clinical Endocrinology and Metabolism Biography:

Research Interest: The novel functions of calcineurin B subunit (CnB) in the activation of innate immunity and in cancer treatment. We have identified the integrin αM as a new receptor of CnB on macrophage and revealed how this receptor mediates CnB-triggered anti-tumor activity. We also showed that CnB protein can synergize with inteferon-γ to skew tumor-associated macrophages (TAMs) to an anti-tumor phenotype (M1 phenotype) and to enhance inteferon-γ- mediated tumoricidal activity. So far, I mainly focus on the molecular mechanisms of necroptosis (a new form of programmed cell death). We are trying to reveal new modulators in the regulation of necroptotic pathway, and to reveal the roles and mechanisms of necroptosis in tumorgenisis and metastasis

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