Open Access Research Article Article ID: JSSR-1-113

    HER2 Status in Male Breast Carcinoma: a Single North African Institution Experience of 10 Cases and Review of the Literature

    Meriem N Mrabent, Noria Harir, Feriel Sellam*, Soumia Zeggai, Abdenacer Tou, Mustapha Diaf, Rachida Salah and Soraya Moulesshoul

    Background: To investigate clinic-pathological characteristics, hormonal receptors and HER2 receptor of male breast cancer.

    Materials and methods: Retrospective study of 10 cases between 2010 and 2013. The studied parameters were: tumor size, histological type, histological grade, lymph node status, hormonal status and overexpression of HER2.

    Results: The average age of our patients was 60.2 years, in 70% of cases; the histological size that was found was T4; and infiltrating ductal carcinoma was diagnosed in all cases. The grades classification was as follow: grade 2 (30%) and grade 3 (70%). 70% of cases had lymph node metastasis. Estrogen and progesterone receptors (ER,PR) were positive in 60% of tumors. Overexpression of HER2 was positive (Score3) in one case. Luminal B was the most common subtype in our study.

    Conclusion: Male breast cancer is a rare disease with a poor prognosis despite the recent increase in incidence in recent years. The diagnosis is often delayed and injuries are treated in advanced stages.


    Published on: Oct 28, 2015 Pages: 49-52

    Full Text PDF Full Text HTML DOI: 10.17352/2455-2968.000013
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