Abstract

    Open Access Research Article Article ID: JSSR-1-113

    HER2 Status in Male Breast Carcinoma: a Single North African Institution Experience of 10 Cases and Review of the Literature

    Meriem N Mrabent, Noria Harir, Feriel Sellam*, Soumia Zeggai, Abdenacer Tou, Mustapha Diaf, Rachida Salah and Soraya Moulesshoul

    Background: To investigate clinic-pathological characteristics, hormonal receptors and HER2 receptor of male breast cancer.

    Materials and methods: Retrospective study of 10 cases between 2010 and 2013. The studied parameters were: tumor size, histological type, histological grade, lymph node status, hormonal status and overexpression of HER2.

    Results: The average age of our patients was 60.2 years, in 70% of cases; the histological size that was found was T4; and infiltrating ductal carcinoma was diagnosed in all cases. The grades classification was as follow: grade 2 (30%) and grade 3 (70%). 70% of cases had lymph node metastasis. Estrogen and progesterone receptors (ER,PR) were positive in 60% of tumors. Overexpression of HER2 was positive (Score3) in one case. Luminal B was the most common subtype in our study.

    Conclusion: Male breast cancer is a rare disease with a poor prognosis despite the recent increase in incidence in recent years. The diagnosis is often delayed and injuries are treated in advanced stages.

    Keywords:

    Published on: Oct 28, 2015 Pages: 49-52

    Full Text PDF Full Text HTML DOI: 10.17352/2455-2968.000013
    CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat

    Global Views

    Case Reports

    Peertechz Tweets

    Pinterest on JSSR