Research Interest: My lab focuses on the
involvement of the heme oxygenase (HO) system and nuclear receptors in
metabolic diseases, which includes obesity and diabetes as well as cancer. The
HO system maintains metabolic balance by signaling to biliverdin reductase that
produces the antioxidant, bilirubin. My lab looks at the how HO, bilirubin, and
nuclear receptors signal for balance in metabolic disorders. We are currently
studying how bilirubin can aid the nutrient and lipid sensing nuclear receptors,
the PPARs (PPAR alpha, PPAR gamma, and PPAR delta), in the maintenance of
metabolic homeostasis. Other nuclear receptors are stress sensing, such as the
glucocorticoid receptors (GRalpha and GR beta), which regulate the immune
system balance and glucose production during times of stress. Altogether, we
look at the PPARs and GRs regulation of the balance of lipids and glucose as
well as maintain growth of cancer cells.
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Rafal Tomasz Pawliczak
Medical University of Lodz, Poland Open Journal of Asthma |
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Osmar Antonio Centurion
Asuncion National University, Paraguay Global Journal of Medical and Clinical Case Reports |
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Domenico Antonio Restivo
Nuovo Garibaldi Hospital, Italy Journal of Neurology, Neurological Science and Disorders |
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Manuel Jose Lis Arias
Polytechnic University of Catalonia, Spain Archive of Biochemistry |
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Peter Lloyd Nara
Private Compnay- Biological Mimetics, Inc., USA Annals of Antivirals and Antiretrovirals |
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Hongxing Dai
Beijing University of Technology , PR China Journal of Civil Engineering and Environmental Sciences |
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M.Waheed Roomi
Dr. Rath Research Institute 1260 Memorex Drive, Santa Clara, USA Global Journal of Cancer Therapy |
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Richard Kones
Cardiometabolic Research Institute, USA Journal of Cardiovascular Medicine and Cardiology |
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Abu-Hussein Muhamad
University of Athens , Greece International Journal of Oral and Craniofacial Science |
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Tsuyoshi Shirakawa
Kyushu University, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan Global Journal of Cancer Therapy |
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