Terry D

Health Science Campus
University of Toledo
Journal Associated: International Journal of Clinical Endocrinology and Metabolism Biography:

Research Interest: My lab focuses on the involvement of the heme oxygenase (HO) system and nuclear receptors in metabolic diseases, which includes obesity and diabetes as well as cancer. The HO system maintains metabolic balance by signaling to biliverdin reductase that produces the antioxidant, bilirubin. My lab looks at the how HO, bilirubin, and nuclear receptors signal for balance in metabolic disorders. We are currently studying how bilirubin can aid the nutrient and lipid sensing nuclear receptors, the PPARs (PPAR alpha, PPAR gamma, and PPAR delta), in the maintenance of metabolic homeostasis. Other nuclear receptors are stress sensing, such as the glucocorticoid receptors (GRalpha and GR beta), which regulate the immune system balance and glucose production during times of stress. Altogether, we look at the PPARs and GRs regulation of the balance of lipids and glucose as well as maintain growth of cancer cells.


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