Saidulu Mattapally

M.Sc., Ph.D.
Division of Pulmonary, School of Medicine
The University of Alabama at Birmingham
Journal Associated: Studies on Stem Cells Research and Therapy Biography:

Research Interest: Research mainly focused on Stem cells, cell differentiation, and dedifferentiation, Congenital Heart Disease, Diabetic Cardiomyopathy, Pharmacology, Molecular Genetics and Pulmonary Cardiac Regeneration.

Grants: Travel Grants for ASHG (DST, DBT from India), AHA and UAB.


List Of Publications:

1. Mattapally S, Surolia R, Li FJ, Wang Z, Guo Y, Antony VB. Role Of Peptidyl Arginine Deiminases In The Pathogenesis Of Calcified Pleural Plaque Formation Following Asbestos Exposure. (Manuscript preparation).

2. Mattapally S, Z Mattapally S, Pawlik KM, Fast VG, Zumaquero E, Lund FE, Randall TD, Townes TM, Zhang J.. Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy. J Am Heart Assoc. 2018 Dec 4;7(23):e010239. DOI: 10.1161/JAHA.118.010239.

3. Mattapally S, Zhu W, Fast VG, Gao L, Worley C, Kannappan R, Borovjagin A, Zhang J. Spheroids of cardiomyocytes derived from human induced-pluripotent stem cells improve recovery from myocardial injury in mice. Am J Physiol Heart Circ Physiol. 2018 Aug 1;315 (2):H327-H339.

4. Mattapally S, Cukier-Meisner W.K, Zhang J. (2017) Differentiation and Use of Induced Pluripotent Stem Cells for Cardiovascular Therapy and Tissue Engineering. In: Ieda M., Zimmermann WH. (eds) Cardiac Regeneration. Cardiac and Vascular Biology. Springer. DOI

5. Gao L, Gregorich Z, Zhu W, Mattapally S, Oduk Y, lou X, Kannappan R, Borovjagin A, Walcott G, Pollard A, Fast V, Hu X, Lloud SG, Ge Y, Zhang J: Large Cardiac-muscle Patches Engineered from Human Induced-pluripotent Stem-cell derived Cardiac Cells Improve Recovery from Myocardial Infarction in Swine. Circulation 2017.

6. Zhu W, Zhao M, Mattapally S, Zhang J: CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle. Circulation Research 2017. 121:9.

7. Mattapally S, Nizamuddin S, Murthy KS, Thangaraj K, Banerjee SK. c.620C>T mutation in GATA4 is associated with congenital heart disease in South India. BMC Medical Genetics 2015, 16:7.

8. Mattapally S, Singh M, Murthy KS, Asthana S, Banerjee SK. Computational modeling suggests impaired interactions between NKX2.5 and GATA4 in individuals carrying a novel pathogenic D16N NKX2.5 mutation. Oncotarget 2018_ 9 (17), 13713.

9. Mattapally S, Banerjee SK: Nitric oxide: Redox balance, protein modification and therapeutic potential in cardiovascular system. IIOAB Journal 2011, 2:29-38.

10. LaBarge W, Mattapally S, Kannappan R, Fast VG, Pretorius D, Berry JL, Zhang J. Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation. PLoS One. 2019 Sep 30;14(9):e0223424.

11. Kannappan R, Mattapally S, Pooja S, Zhang J. Transactivation Domain of P53 Regulates DNA Integrity in Human Cardiac Fibroblast Derived iPS Cells. Communicated.

12. Pala RS, Pathipati UR, Mattapally S, Banerjee SK. Ultra-small silver nanoparticles induced ROS activated Toll-pathway against Staphylococcus aureus disease in silkworm model. Materials Science and Engineering, 2017: C 77, 990-1002.

13. Bagul PK, Middela H, Matapally S, Padiya R, Bastia T, Madhusudana K, Reddy BR, Chakravarty S, Banerjee SK. Attenuation of Insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. Pharmacological Research, 2012, 66(3): 260-268.

14. Zhao M , Fan C, Ernst PJ , Tang Y, Zhu H , Mattapally S , Oduk Y , Borovjagin AV , Zhou L , Zhang J, , Zhu W. Y-27632 Preconditioning Enhances Transplantation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Myocardial Infarction Mice. Cardiovasc Res. 2019 Feb 1;115(2):343-356.

15. Adela R, Nethi SK, Bagul PK, Barui AK, Mattapally S, Kuncha M, Patra CR, Reddy PN, Banerjee SK. Hyperglycaemia Enhances Nitric Oxide Production in Diabetes: A study from Indian Patients. PLoS One. 2015 Apr 20;10(4).

16. Nethi SK, Veeriah V, Barui AK, Rajendran S, Mattapally S, Misra S, Chatterjee S and Patra CR. Investigation of molecular mechanisms and regulatory pathways of pro-angiogenic nanorods. Nanoscale. 2015,7, 9760-9770.

17. Santhoshi A, Mahendar B, Mattapally S, Sadhua P, Banerjee SK, Rao VJ. Synthesis of Thio-HeterocyclicAnaloguesfrom Baylis-Hillmann Bromides as Potent Cyclooxygenase-2 Inhibitors. Bioorg Med Chem Lett, 2014, 24 (8), 1952-1957.

18. Ravinder M, Mahendar B, Mattapally S, Hamsini KV, Reddy TN, Rohit C, Srinivas K, Banerjee SK, Rao VJ. Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiestarase3 (PDE3): A target for heart failure and platelet aggregation. Bioorg Med Chem Lett, 2012, 22(18): 6010-6015.


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