Ramazan Erenler

Tokat Gaziosmanpasa University
Journal Associated: Open Journal of Chemistry Biography:

Ramazan Erenler is a full Professor in the Department of Chemistry, Faculty of Arts and Sciences Tokat Gaziosmanpasa University, Turkey, head of the Synthetic Organic Chemistry Laboratory and Plant Research Laboratory. He has completed his PhD in the field of Organic Chemistry from Tokat Gaziosmanpasa Universiyt, Turkey and postdoctoral studies from Academia Sinica, Taiwan, and Kansas State University, USA in synthetic Organic Chemistry. Dr. Erenler visited some European universities for seminars and research. He has published seventy eight (78) scientific articles in peer reviewed journals. He joined the many international congresses and publised 110 conference proceedings. Dr. Erenler’s research focuses on the area of Plant Chemistry, isolation and identification of secondary metabolites from plants and investigation of their antioxidant and anticancer activities.

Research Interest: Natural Product Chemistry, Organic Chemistry, Synthesis, Isolation and identification of active compounds from plants, Spectroscopy, Chromatography, Biological activity, Antioxidant activity, Anticancer activity

List of Publications: 

Papers (SCI)

1. Topçu, G.; Erenler, R.; Çakmak, O.; Johansson, C. B.; Çelik, C; Chai, H.-B. Pezzuto, J, M. Diterpenes from the berries of juniperus excelsa. Phytochemistry,  50, 1195-1199 (1999).

2. Demirtas, İ; Erenler, R.; ve  Çakmak, O. Synthetic route to 1,3-disubstituted naphthalene derivatives, Journal of Chemical Research (S), 524-526. (2002).

3. Çelik, İ; Demirtaş, İ; Akkurt, M.; Erenler, R.; Güven, K.; Çakmak, O. Crystal  Structure of  cis,cis,cis-1,2-epoxy-3,5-dibromo-4-hydroxy tetralin, Crystal Research and Technology, 38, 2,193-196. (2003).

4. Elmastaş, M.; Öztürk, L.; Gökçe, İ.; Erenler, R.; Aboul-Enein, H. Y.,  Determination of antioxidant activity of marshmallow flowers (Althea officinalis L.). Analitical Letters, 37, 9, 1859-1861 (2004).

5. Çelik, İ.; Akkurt M.; Demirtas, İ.; Erenler, R. ve Güven, K., The Crystal structure of -phenil-N-thioacetylmorpholine. Analytical Science, 20, x89-x90 (2004).

6. Öztürk, S.; Büyükkıdan, B.; Erenler, R.; Akkkurt, M.; Çakmak, O. ve Fun, H-K. Crystal Structure of 1,4-dihydroxy-3,4-dibromo-1,2,3,4-tetrahydro-napthalene. Cryst. Res. Technol. 39, 9, 815-820. (2004).

7. Akkurt, M.; Çelik, İ.; Erenler, R.; Çakmak, O.; Ersanli, C. C.; Büyükgüngör, O., Trans,trans,trans-2,3,5,8-tetrabro-1,4-dihydroxy- 1,2,3,4-tetrahydro-naphthalene. Acta Crystallograpica Section E, E60, 2096-2098, (2004).

8. Erenler, R. ve Çakmak, O., Synthesis of hexabromo, hydroxy, epoxy, methoxy, and nitroxy derivatives of tetralins and naphthalenes. J. Chem. Res., 8, 566-569, (2004).

9. Erenler, R. and Biellmann, J-F. Facile conversion of pyridine propargylic alcohols to enones: stereochemistry of protonation of allenol. Tet. lett., 46, 34, 5683-5685. (2005).

10. Çakmak, O.; Erenler, R.; Tutar, A.; Celik, N. Synthesis of New Anthrecene Derivatives. J. Org. Chem. 71, 5, 1795-1801, (2006).

11. Çelik, İ.; Akkurt, M.; Erenler, R.; Cakmak O. and Ersanlı, C. C., trans, trans, trans-1,4-Dimethoxy-2,3,5,8-tetrabromotetralin. Acta Crystallograpica Section E, E62, 4609-4610, (2006).

12. Erenler, R.; Synthesizing of 1-phenyl-3-(pyridine-4-yl)prop-2-ynyl acetate. Asian Journal Of Chemistry, 19, 3, 2207-2210 (2007).

13. Erenler, R.; Demirtas, İ; Büyükkıdan, B.; ve Çakmak, O., Synthesis of hydroxy, epoxy, nitroxy and methoxy derivatives of tetralins and naphthalenes. J. Chem. Reseach., 753-757, (2006).

14. Erenler, R. and Biellmann,J. F. ; Synthesis of pentafluorophenyl- and pyridinyl-3 allenes. J. Chem. Soc. China, 54(1),103-108, (2007).

15. Erenler,  R. Synthesıs of allenic naphthalene derivatives. Bull. Chem. Soc. Ethiop. 2007, 21(2), 241-247.

16. İ. Çelik, R. Erenler, M. Akkurt, C. Sancak Ünlü, A. Tutar ve S. Garcia-Granda. Crystal structure of 1,2,3-tribromobenz[f]indane. Analytıcal Scıences 2007, Vol. 23, X229.

17. Erenler, R., Uno M, Goud TV, Biellmann JF. Preparation of some heterocyclic enones and ynones by isomerisation of the propargylic alcohols. J.Chem.Res.7, 459-464, 2009.

18. Ramazan Erenler, Synthesis and Characterization of Pyridyl Propargyloximes. Asian Journal of Chemistry, 23, 8, 3546-3548, 2011.

19. Ramazan Erenler, Facile and Efficient Synthesis of Ethyl 3-oxo-3-(pyridin-4-yl)-2-((pyridin-4-yl)methylene)propanoate, Asian Journal of Chemistry, 23, 8, 3763-3764, 2011.

20. Unsalan, O., Tutar, A., Unlu, C.S., Erenler, R. FTIR spectroscopic and quantum-chemical studies on some tribromoindenes and their isomers, OPTICS AND SPECTROSCOPY, 111, 6, 894-903, 2011

21. İsmail Çelik, Mehmet Akkurt, Ahmet Tutar, Ramazan Erenler and Santiago Garcia-Granda. 2,3-Dihydro-1H-cyclopenta[b]naphthalen-1-ol. Acta Cryst. (2012). E68, o687.

22. İsmail Celik, Mehmet Akkurt, Makbule Yılmaz, Ahmet Tutar, Ramazan Erenler and Santiago Garcia-Granda, 5-Amino-4-bromo-2,3-dihydro-1Hinden-1-one, Acta Crystallographica Section E, 68, 0833. 2012

23. Ismail Celik, Mehmet Akkurt, Makbule Yılmaz, Ahmet Turar, Ramazan Erenler, Canan Kazak. 2,4-Dibromo-2,3-dihydro-1H-inden-1-yl-acetate. Acta Crystallographica Section E, 68, 01884. 2012

24. Cihansel Sancak Unlu, Ahmet Tutar, Ramazan Erenler. Facile and Efficient Bromination of Benz[F]Indan-1-One. J.Chem.Soc.Pak., Vol. 34, No. 3, 705-708, 2012,

25. Ramazan Erenler and Jean-François Biellmann, 1-Methyl-4-ethynylpridinum triflate: Reaction with thiophenol giving rise to chromophoric (E)-1-methyl-4-[2-(phenylsulfanyl)-1-ethenyl]pyridinium triflate. An example of nucleophilic reaction on triple bond, . J.Chem.Soc.Pak., Vol. 34, No.5, 1224-1228, 2012

26. Ahmet Tutar, Ramazan Erenler. Bromination of Benz[f]indene: Synthesis of New Benz[f]indane Derivatives, J.Chem.Soc.Pak. Vol:34, No:6, 1526-1530, (2012).

27. Ismail Celik, Mehmet Akkurt, Makbule Yilmaz, Ahmet Tutar, Ramazan Erenler and Santiago Garcia-Granda. 2,5-Dibromoindan-1-ol. Acta Cryst. (2012). E68, o2795–o2796

28. Ibrahim Demirtas, Ramazan Erenler, Mahfuz Elmastas, Ahmet Goktasoglu. Studies on the antioxidant potential of water-soluble fraction and isolated flavones of Allium vineale. Food Chemistry, 136, (2013) 34-40.

29. Ayse Sahin Yaglıoglu, Bayram Akdulum, Ramazan Erenler, Ibrahim demirtas, Isa Telci, Saban Tekin. Antiproliferative activity of pentadeca-(9e, 13zdien-11-yn-2-one 1 and (e)-1,8-pentadecadiene 2 from Echinacea pallida (nutt.) nutt. Roots. Medicinal Chemistry Research. (2013), 22:2946-2953, DOI: 10.1007/s000-012-0297-2.

30. Makbule Yılmaz, Ahmet Tutar, Ramazan Erenler. Synthesis of Bromoaminoindane and Bromoaminoindanone Derivatives. J. Chem. Res. 4, 232-235 (2013).

31. Salih Ökten, Osman Çakmak, Ramazan Erenler, Önem Yüce, Şaban Tekin. A simple and convenient preparation of novel 6,8-disubstituted quinoline derivatives and their promising anticancer activities. Turk J Chem. (2013) 37: 896-908.

32. Ahmet Tutar, Ramazan Erenler, Jean-François Biellmann. Synthesis of 8-substituted 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene dyes (BODIPY). J. Chem. Soc. Pak., 35, No.4, 1197-1201 (2013).

33. K. Geetha, M. Umadevi, G.V. Sathe, R. Erenler. Spectroscopic investigations on the orientation of1,4-dibromonaphthalene on silver nanoparticles.  Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 116 (2013) 236–241.

34. Ramazan Erenler, Sakine Yilmaz, Huseyin Aksit, Ozkan Sen, Nusret Genc, Mahfuz Elmastas and Ibrahim Demirtas. Antioxidant Activities of Chemical Constituents Isolated from Echinops orientalis Trauv. Record of Natural Product, 8:1 (2014)32-36.

35. Hüseyin Akşit, Süleyman M. Çelik, Özkan Şen, Ramazan Erenler, İbrahim Demirtaş, İsa Telci, Mahfuz Elmastaş. Complete Isolation and characterisation of Polar Portion of Mentha dumetorum water extract. Record of Natural Product. 8:3, 277-280, 2014.

36. Jianyu Lu, Izumi Maezawa, Sahani Weerasekara, Ramazan Erenler, Tuyen D. T. Nguyen, James Nguyen, Luxi Z. Swisher, Jun Li, Lee-Way Jin, Alok Ranjan, Sanjay K. Srivastava, Duy H. Hua. Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3b of substituted quinolines. Bioorganic & Medicinal Chemistry Letters. 24, 3392–3397 (2014).

37. Salih ÖKTEN, Ramazan ERENLER, Tuğba KUL KÖPRÜLÜ, Şaban TEKİN. In vitro antiproliferative / cytotoxic activity of 2,3'-biindole against various cancer cell lines. Turkish Journal of Biology. (2015) 39: 15-22.

38. Ramazan Erenler, Isa Telci, Musa Ulutas, Ibrahim Demirtas, Fatih Gul, Mahfuz Elmastas and Omer Kayir. Chemical Constituents, Quantitative Analysis and Antioxidant Activities of Echinacea purpurea (L.) Moench and Echinacea pallida (Nutt.) Nutt. Journal of Food Biochemistry. (2015).  39 (2015) 622–630.


39. Mahfuz Elmastaş, İsa Telci, Hüseyin Akşit, Ramazan Erenler. Comparison of total phenolic contents and antioxidant capacities in mint genotypes used as spices. Turkish Journal of Biochemistry – Türk Biyokimya Dergisi 2015; 40(6): 456–462. DOI: 10.1515/tjb-2015-0034.

40. Mahfuz Elmastas, Ramazan Erenler, Besir Isnac, Huseyin Aksit, Ozkan Sen, Nusret Genc & Ibrahim Demirtas. Isolation and identification of a new neo-clerodane diterpenoid from Teucrium chamaedrys L. Natural Product Research, Vol. 30, No. 3, 299–304, 2016. http://dx.doi.org/10.1080/14786419.2015.1057583.

41. Ramazan Erenler, Ozkan Sen, Ayse Sahin Yaglioglu ve Ibrahim Demirtas. Bioactivity-guided Isolation of Antiproliferative Sesquiterpene Lactones from Centaurea solstitialis L. ssp. Solstitialis. Combinatorial Chemistry & High Throughput Screening, 2016, 19, 66-72.

42. Ramazan Erenler, Ozkan Sen, Huseyin Aksit, Ibrahim Demirtas, Mahfuz Elmastas, İsa Telci. Isolation and identification of chemical constituents from Origanum majorana and investigation of antioxidant activities. Journal of the Science of Food and Agriculture. (2016), 96: 822–836. Doi: 10.1002/jsfa.7155.

43. Ramazan Erenler, Ozkan Sen, Ilyas Yildiz and Ali Aydın. Antiproliferative Activities of Chemical Constituents Isolated from Thymus praecox subsp. grossheimii (Ronniger) Jalas. Rec. Nat. Prod. 10:6 (2016) 766-770.

44. Ramazan Erenler, Koksal Pabuccu, Ayse Sahin Yaglioglu, Ibrahim Demirtas and Fatih Gul. Chemical constituents and antiproliferative effects of cultured Mougeotia nummuloides and Spirulina major against cancerous cell lines. Z. Naturforsch. 2016; 71(3-4)c: 87–92.

45. İsmail Celik, Cem Cuneyt Ersanlı, Rahmi Koseoglu, Huseyin Aksit, Ramazan Erenler, Ibrahim Demirtas¸ and Mehmet Akkurt. Crystal structure of 3,4a,7,7,10a-pentamethyl-3- vinyldodecahydro-1H-benzo[f]chromen-9-ol isolated from Sideritis perfoliata. Acta Cryst. (2016). E72, 1380–1382.

46. Ahmet Tutar, Ramazan Erenler. Bromination of 4-Bromoindanone and 5-Bromoindanone, Facile Synthetic Access to 3,5,10-tribromo-7H-benzo[c]fluoren-7-one. J.Chem.Soc.Pak., Vol. 38, No. 03, 2016. 546-552.

47. Ilyas Yildiz, Ozkan Sen, Ramazan Erenler, Ibrahim Demirtas & Lutfi Behcet. Bioactivity–guided isolation of flavonoids from Cynanchum acutum L. subsp. sibiricum (willd.) Rech. f. and investigation of their antiproliferative activity. Natural Product Research. 2017.  http://dx.doi.org/10.1080/14786419.2017.1289201.

48. Abdussamat Guzel, Huseyin Aksit, Mahfuz Elmastas, Ramazan Erenler. Bioassay-guided isolation and identification of antioxidant flavonoids from Cyclotrichium origanifolium (Labill.) Manden and Scheng. 2017. Pharmacognosy Magazine 2017;13:316-20.

49. Ramazan Erenler, Bilal Meral, Ozkan Sen, Mahfuz Elmastas, Ali Aydin, Ozgur Eminagaoglu & Gulacti Topcu. Bioassay-guided isolation, identification of compounds from Origanum rotundifolium and investigation of their antiproliferative and antioxidant activities. PHARMACEUTICAL BIOLOGY, 2017 VOL. 55, NO. 1, 1646–1653.

50. Tunay Karan, Ramazan Erenler. Screening of Norharmane from Seven Cyanobacteria by High‑performance Liquid Chromatography. Pharmacognosy Magazine. Volume 13 | Issue 51 | July-September 2017 (Supplement 3).

51.Tunay Karan, Ilyas Yildiz, Ali Aydin and Ramazan Erenler. Inhibition of Various Cancer Cells Proliferation of Bornyl Acetate and Essential Oil from Inula graveolens (Linnaeus) Desf. Rec. Nat. Prod. (2018) 12:3 273-283.

52. Tunay Karan, Ramazan Erenler. Fatty acid constituents and anticancer activity of

Cladophora fracta (OF Müller ex Vahl) Kützing. Tropical Journal of Pharmaceutical Research 2018; 17 (10): 1977-1982.

53. Perihan Koysu, Nusret Genc, Mahfuz Elmastas, Huseyin Aksit, Ramazan Erenler Isolation, identification of secondary metabolites from Salvia absconditiflora and evaluation of their antioxidative properties. Natural product research. https://doi.org/10.1080/14786419.2018.1488700.

54. Ramazan ERENLER, İsa TELCİ, Mahfuz ELMASTAŞ, Hüseyin AKSİT, Fatih GÜL, Ali Rıza TÜFEKÇİ, İbrahim DEMİRTAŞ, Ömer KAYIR. Quantification of flavonoids isolated from Mentha spicata in selected clones of Turkish mint landraces. Turk J Chem (2018) 42: 1695 – 1705.

55. F Gokalp, R Erenler. Theoretical Study of Synthesis of 1, 3-dibromonaphthanlene. JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN 40 (6), 1089-1092

56. M Elmastas, SM Celik, N Genc, H Aksit, R Erenler, İ Gulcin. Antioxidant activity of an anatolian herbal tea—Origanum minutiflorum: isolation and characterization of its secondary metabolites. International Journal of Food Properties 21 (1), 374-384

Other Publication:

1. Abser, M. N.; Karim, M. M.; Kausar, A.; Matin, M. A.; Molla, M. E.; Yeasmin, Z. and    Erenler, R. Synthesis and Liquid Crystalıne Behavior of bis[N-(3-Hydrazinato]Nikel (II) Complexes. Jahangirnagar University Journal of Science, 28, 7-21, (2005).

2. M. N. Abser, M. M. Alam, M. R. Alam, M. Hossain, M. M. Karim, M. A. Matin, M. E. Molla and R. Erenler. Synthesis and Characterisation of Some Chlorobenzylidene Derivatives of Aroylhydrazinatonicel (II) Complexes. Jahangirnagar University Journal of Science, Vol:29, 1-8, 2006.

3. D. Çelik, A. Tutar, R. Erenler. Short and Selective Synthesis of 3,5-dibromoinden-1-one, Journal of New Results in Science, 1, 1-4, 2012.

4. İbrahim DEMİRTAŞ, Nuri Kaan İNAH, Serkan KOLDAŞ, Ömer Cem KARAKOÇ, Ali Rıza TÜFEKÇ, Fatih GÜL, İsa TELCİ, Ramazan ERENLER, Muhammed ALTUN. Değerlendiremediğimiz Tarım Ürünleri Potansiyelimiz. Tarım Bilimleri Araştırma Dergisi 6 (1): 168-173, 2013 ISSN: 1308-3945, E-ISSN: 1308-027X, www.nobel.gen.tr

5. Necla Türkmen, Ayşenur Öz, Aslı Sönmez, Tuğçe Erola, Deniz Gülümser, Burcu Yurdakul, Ömer Kayır, Mahfuz Elmastas, Ramazan Erenler. Chemical Composition of Essential Oil from Rosmarinus Officinalis L. Leaves. Journal of New Results in Science 6 (2014) 27-31.

6. Burcu Bayir, Hatice Gündüz,  Tuba Usta, Esma Şahin, Zeynep Özdemir, Ömer Kayıra, Özkan Şen, Hüseyin Akşit, Mahfuz Elmastaş, Ramazan Erenler. Chemical Composition of Essential Oil from Marrubium Vulgare L. Leaves. Journal of New Results in Science 6 (2014) 44-50.

7. Gamze Kaya, Rukiye Karakaya, Esma Tilgel, Merve Sandikçı, Esra Yücel, Gayya Çicek, Ömer Kayır, Hüseyin Akşit, İsa Telci, Abdussamat Güzel, Mahfuz Elmastas, Ramazan Erenler. Essential Oil Constituents of Thuja orientalis Berries. Journal of New Results in Science 7 (2014) 1-6.

8. İsmail Çelik, Mehmet Akkurt, Hüseyin Akşit, Ramazan Erenler, Santiago Garcia-Granda. Crystal structure and computational study of 3,4-dihydroxy-3-hydroxymethyl-9-methyl-6-methylidene-3a,4,5,6,6a,9,9a,9b-octahydroazuleno[4,5-b]furan-2,8(3H,7H)-dione. Acta Cryst. (2015). E71, 1425–1428.  Thomson Reuters Emerging Sources Citation Index (ESCI).

9. Ali Aydın, Ramazan Erenler, Bulent Yılmaz, Şaban Tekin. Antiproliferative effect of Cherry laurel. Journal of the Turkish Chemical Society. JOTCSA 3(3), 217-228. 2016.

10. Tunay Karan, Ramazan Erenler, Zekeriya Altuner, Mahfuz Elmastas. Molecular Identification and Norharmane Quantification of Cyanobacterium, Geitlerinema carotinosum. International Journal of Pharmacy and Pharmaceutical Research. Ijppr.Human, 2017; Vol. 9 (3): 66-73.

11. Tunay Karan, Ramazan Erenler, Zekeriya Altuner. Isolation and Molecular Identification of Some Blue-Green Algae (Cyanobacteria) from Freshwater Sites in Tokat Province of Turkey. Turkish Journal of Agriculture - Food Science and Technology, 5(11): 1371-1378, 2017.

12. Ramazan Erenler, Tugba Adak, Tunay Karan, Mahfuz Elmastas, Ilyas Yildiz, Huseyin Aksit, Gulacti Topcu, Murat Aydin Sanda. Chemical Constituents Isolated From Origanum Solymicum With Antioxidant Activitites. The Eurasia Proceedings of Science, Technology, Engineering & Mathematics (EPSTEM). Volume 1, Pages 139-145. 2017.

13. Tunay Karan, Zekeriya Altuner, Ramazan Erenler. Growth and Metabolite Production of Chroococcus minutus Under Different Temperature and Light Conditions. 

JOURNAL OF NEW RESULTS IN SCIENCE (JNRS).  Volume: 6 Issue: 1 Year: 2017 Pages: 47-52.

14.  Ramazan ERENLER, Ibrahim DEMIRTAS, Tunay KARAN, Muhammed ALTUN, Fatih GUL. Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro. Int. J. Sec. Metabolite, Vol. 4: 3 (2017) pp. 512-516

15. Tunay KARAN, Omer KAYIR, Zekeriya ALTUNER, Ramazan ERENLER. Growth and norharmane production of Chroococcus minutus under various stress conditions. Int. J. Chem. Technol. 2018, 1, 10-15.

16. Tunay Karan, Seyda Simsek, Ilyas Yildiz, Ramazan Erenler. Chemical Composition and Insecticidal Activity of Origanum syriacum L. Essential Oil Against Sitophilus oryzae and Rhyzopertha dominica. International Journal of Secondary Metabolite 2018, Vol. 5, No. 2, 87–93.

17. İsmail Çelik, Zeliha Atioğlu, Huseyin Aksit, Ibrahim Demirtas, Ramazan Erenler, Mehmet Akkurt. Crystal structure and Hirshfeld surface analysis of 2-oxo-13-epi-manoyl oxide isolated from Sideritis perfoliata. Acta Crystallographica Section E: Crystallographic Communications. 2018. Cilt, 74, Sayı: 5, Sayfalar: 713-717


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