Cite this asFleming RM, Fleming MR, Chaudhuri TK (2020) What is the role for treatment of hyperlipidemia in the primary prevention patient? J Cardiovasc Med Cardiol 7(1): 004-005. DOI: 10.17352/2455-2976.000104
It is reported that Hippocrates said If someone wishes for good health, one must first ask oneself if he is ready to do away with the reasons for his illness. Only then is it possible to help him and Our food should be our medicine and our medicine should be our food.
While we may never know if Hippocrates actually made these statements, they seem intuitively valid. In the later half of the 20th Century, changes in dietary and lifestyle practices raised the awareness of the importance of diet and lifestyle and the development of chronic inflammatory diseases-entering the lexicon -and the understanding that it is this inflammatory process which is ultimately responsible for the development of many of our chronic diseases, including coronary artery disease , which has gone on to become the number one killer of people worldwide. This case introduces one such example that should remind us to remain vigilant to what Hippocrates said.
A middle age gentleman without known history of prior medical problems underwent routine blood work, revealing an elevated total cholesterol level of 146 mg/dl (3.77 mmol/l). He elected not to begin lipid-lowering medications quoting Hippocrates (above). He stated he planned to change his diet and promised to return in 6-months for repeat blood work.
Six months later he returned at which time his total cholesterol was 230 mg/dl (5.95 mmol/l). When he was seen in the clinic, it was discovered that he had been experiencing intermittent chest discomfort.
Following recommendations promulgated for decision making in individuals without prior cardiac events and elevated lipids , the patient was referred for a coronary artery calcium test (Figure 1A), which revealed no evidence of calcium. He was then referred for cardiology evaluation and subsequently underwent cardiac catheterization given the clinical suspicion by his cardiologist, revealing a 99% narrowing of his proximal left anterior descending coronary artery (Figure 1B-left image) followed by treatment (Figure 1B-right image).
In recent years, there has been considerable debate [4-6] over evidence-based outcomes and the treatment of hyperlipidemia – particularly in the setting of primary prevention. The fundamental question being one of How to best approach the patient with elevated lipids ? Partially in response to these questions, medical organizations have attempted to develop evolving guidelines utilizing changes in diagnostic tools such as coronary artery calcium (CAC) scores which look for one component of coronary atherosclerosis-sclerosis-but is truly only a test for calcium thereby potentially limiting its application .
While the time tested cardiac catheterization-coronary lumenogram-also has its limitations [8-10], like CAC, when positive for the detection of coronary artery disease (CAD), as it was in this instance, it can be a life saver-particularly when coupled with initial treatment (stenting), as it was in this case. We emphasize the term initial treatment because all too often, patients and sometimes their physicians are under the impression that once a stent is placed, they no longer have CAD.
The very inflammatory plaque that inflamed and impaired the coronary artery, eventually invading the coronary lumen, remains behind after angioplasty (PTCA) or stent placement. As we now know, the act of PTCA with or without stent placement produces iatrogenic damage to the wall of the coronary artery through the outward displacement of the tunica intima, media and externa, with loss of integrity of the external elastic membrane. A small price to pay given the alternatives, but nonetheless a consequence, which should not be ignored or forgotten about. Understanding the continued nidus for further inflammation  is of the utmost importance in understanding not only how the patient developed their CAD, but the attention which needs to be given to the subsequent treatment from here out.
What Would You Do Next?
• Begin intensive statin regimen followed by frequent lipid monitoring to maximize treatment and lower lipid levels.
• Discuss the changes in the dietary patterns followed by the patient during the 6-month period of time leading up to the development of chest discomfort and increased lipid levels and make dietary changes accordingly.
• Schedule a myocardial perfusion imaging study to determine the extent of myocardial damage and ischemia.
• Screen the patient and family members for familial hyperlipidemias and begin treatment of those family members with hyperlipidemia.
The evaluation of both acute and chronic coronary artery disease can be approached either from an anatomic-such as CAC scoring or arteriography approaches-or physiologic perspective-e.g. myocardial perfusion imaging (MPI) including either single photon emission tomography (planar/SPECT) or positron emission tomography (PET). Independent of which approach is considered, our currently utilized methods have too long employed imaging modalities using qualitative or semi-quantitative imaging which miss disease as noted by the continued use of sensitivity and specificity results . Such methods are inferior to quantitative imaging  now made possible with FMTVDM, which can not only define the extent of disease but treatment response-including dietary, statin or other medications, stents, surgery, et cetera-thus making it possible to save time, money and lives. In view of this new knowledge, we need to reconsider our approaches to the diagnosis and treatment of patients with suspected coronary artery disease .
FMTVDM is issued to the first author. All figures are reproduced with the expressed consent of the first author. All patient data is redacted for patient privacy.
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