Disrupt Medicine

From humourism to germs, from exorcism to trephination, from herbs and unguents, and from all that past where medicine was at the borderline between magic and science to our days, the distance is enormous. The history of how disease was identifi ed in various cultures and treated over millennia is probably the most faithful testimony to a progressively better understanding of the human being. Medicine is the most complete—and contradictory—treatise on what life is and what defi nes an individual [1].


Introduction
From humourism to germs, from exorcism to trephination, from herbs and unguents, and from all that past where medicine was at the borderline between magic and science to our days, the distance is enormous. The history of how disease was identifi ed in various cultures and treated over millennia

Reactive vs. Anticipation-informed medicine
Current medicine is anchored in a reactive practice. For all practical purposes, it became an extension of physics and chemistry, operating within the perspective of reductionistdeterminism not of biology, i.e., the science of the living. If physicians do not want to be replaced by machines, they should stop treating human beings as machines. Medical practice grounded in anticipation, which is guided not by reaction, but by possible future outcomes, can save medicine from itself.
Reaction, by its nature, is amoral, void of ethic. Anticipation informed medicine does not eliminate reactive medicine (essential in helping those affected in accidents, for example). the ethical dimension of health care which in the age of the machine reductionism was lost.

The underlying science
Science anchored in reductionist determinism is giving up understanding reality in favor of measuring it. The measured reality becomes numbers. As processed data, they facilitate inferences from the past-causes represented by numbersto the present-effects, as yet other numbers. Data are raw material for predictions void of understanding. This path is legitimate where the subject of change has no active role in making choices. Stones erode into sand; water evaporates, ice melts-all without any trace of intentionality. But that is not the case with the path from the stem cell to a new organism, to aging, to eventual death. The patient plays an important role in healing.
Understanding is a long-term endeavor, with many pitfalls. Suffi ce it to recall that pandemic outbursts were once associated with sin and godly revenge. The meaning of otherwise unexplainable death was hijacked into the irrational. It derives from misconstrued intentionality attributed to constructs (deities, gods and goddesses) meant to explain what seemed unexplainable. Data processed without any understanding of what they stand for is of the same nature. Ascertainments about the future in disregard of meaning are agnostic of intentionality.
The broader crisis of vision, CoVID (VID from the Latin vedere, to see), within which Covid-19 takes place, is the result of giving up knowledge in favor of the more expedient data, in particular automated processing of data. This choice: data over knowledge, i.e. the abandoning of understanding, is the expression of living on borrowed time. Indeed, what is at stake is sustainability Figure 1.
Turning a deeply rooted crisis-the pandemic that affected the entire world--into an opportunity became the justifi cation for the effort to understand the obsession with numbers in disregard of meaning. Huge amounts of money were spent to react to Covid-19 without even understanding what it is. The alternative would have been the meaningful mapping of human interactions represented as signifi cant information. This is also the unavoidable path towards effective prevention. Expensiveand only partially adequate-reactions to breakdowns based on data-driven predictions, but not on knowledge, are not sustainable. Integrating reaction and anticipation, science can be at the same time effective and meaningful.
If someone were to take the mathematics used in the representation of physical phenomena as a model for describing the organism, the number of variable necessary would exceed the number of entities that make up the universe [2]. This illustrates why the predictive power of physics, describing the non-living universe, is insuffi cient should someone attempt to describe change in the living based on it. The virus-organism interaction that eventually led to the pandemics is an example. It constitutes a reality for which not yet enough knowledge has been available in order to understand it to the extent to which something can be done about it, not only describe it. There are a lot of data-no doubt about this-there is little (if any) effective science. That genetics, for example, provides descriptions (in the form of sequencing data) of the make-up of the virus is admirable-but not consequential for treating the sick. With the pandemic, humankind realized that the exploration of the universe (rockets, satellites, measurement technology, etc.) is trivial compared to the new biological entity labelled Covid-19.
The rocket made it to Mars and will generate data about its changes. In the same time interval, people died because current reactive science could not save them. It probably never crossed the minds of those who put their blind trust in the science capable of landing Perseverence on Mars that this same science might, in some ways, be the cause of their SARS-CoV-2 induced anguish. This is a spectrum condition of the human body resulting from its accidental interaction with a virus that existed for millions of years in the ecosphere. It is important to take note of the fact that the corona virus was studied since the SARS (acute respiratory syndrome) epidemic (ca. 2003), but actually known since 1965. However, Dr. Jeffrey Kahn, of the University of Texas Medical Center, stated, "I didn't believe there was a big effort to make vaccines against these because here were thought to be more of a nuisance than anything else" [3]. Infectivity, extremely high, goes to the credit (if the expression can be used in the context of a life-threatening condition) of the human being-sick or only carrying the virus-not to that of the agency-free virus. What also escaped the attention of those desperately seeking to help the victims was the paradoxical fact that the new possibilities opened by science and technology proved to be, at the same time, sources of new risks. In other words, vulnerability is actually self-infl icted. At this point, a bit of history could be useful in explaining the focus on the WHY? question of the pandemic, a bit of history could be useful.

Understanding the Why?
John Snow, celebrated as the founder of epidemiology, traced the source of the cholera epidemic (London 1852-1860) not to miasma ("bad air"), but to contaminated well water, and published On the Mode of Communication of Cholera (1855)which the medical establishment rejected out of hand.
Cholera in England-fi rst cases in 1831. John Snow was at that time still a student of medicine. It is not clear what triggered the outbreak at that time. But there is a long history of plagues of all kinds that Snow was aware of. They go back to the Plague of Athens and the belief that the gods abandoned the Athenians (who in turn faced the curse through extreme indulgence). The plagues extended to the Antonine: almost one-third of the population of the vast Roman Empire perished. Apollo, the "avatar of evil" was of no help. Neither was Christianity. The Plague of Cyprian was named after a bishop, not so much for his healing abilities as for preparing the victims for life after death.
To reference each and every disaster within different cultures and different religions is to accumulate answers to the WHY? question that everyone considered. The answers deliver an epistemological portrait of humankind in its evolution over time. Indeed, it is about what the people in Athens knew, what the Romans started to discover, what the Moslems or the worshippers of Buddha practiced. The Jews, given to handwashing and bathing (based on Biblical injunctions turned into rules defi ning a way of living), were many times spared lethal diseases, only to be accused of having provoked them. The irrationality of the argument did not make it disappear. In our days of epidemiological research well beyond what John Snow accomplished there are, "The Chinese did it," "Americans spread the virus," and, again, the "Jews (this time Israel) caused it"-answers to the WHY? question impossible to ignore. They echo assertions that testify to a primitive mentality: fi nd guilt in the darkest assignment of it to those one hates or despises.
But back to England, 23 years later: 1854, SoHo, a suburb of London, and a terrible situation: people were dying of cholera. The Bishop's pronouncements, along the line of the centuries-old answer that God punishes sinners, called for acts of redemption. Dr. John Snow found out that "within 250 yeards of the spot where Cambridge Street joins Broad Street there were upwards of 500 fatal attacks of cholera in 10 days." This is data: numbers that describe a situation.
There was a hypothesis-the virus was waterborne-and there was anecdotal evidence: the coffee shop served glasses of water from the Broad Street pump along with meals. Nine of the customers got cholera. A woman who no longer lived close to the pump liked the taste of its water so much that she had some delivered to her new address. She died the next day. However, in the neighborhood, the prison, with 535 inmates, had no cholera. It had its own water source. And fi nally, there was the grid, on which data were referenced to particular persons. This made the meaning of data evident: there was a contaminated source of cholera infections. Meaning always informs action: I had an interview with the Board of Guardians of St. James's parish, on the evening of Thursday, 7 th September, and represented the above circumstance to them. In consequence of what I said, the handle of the pump was removed on the following day.

From data to meaning
Data, no matter how "Big," do not answer the WHY? question. They must be referenced to what lies behind them, to the processes from which they are extracted. Practitioners of medicine might not even be aware that one of their precursors, Ignaz Semmelweiss, pleaded (1847) for hygienehandwashing between patient visits-only to be mocked by his colleagues. Doctors were not willing to accept that they themselves contributed to the spreading of disease by rejecting handwashing before treating patients. But surprisingly, in the context of Covid-19, "Wash your hands!" sounded like a new commandment for those not yet really convinced to do it as a matter of routine. It was repeated as though no one has learned anything from the lessons of past pandemics, or even yearly bouts of contagious illnesses. Handwashing (part of hygiene), social distancing, mask wearing, diet, and physical activityanticipatory actions-are elements of behavior [4]. During the lockdowns tried at the climax of Covid-19, and 600 years after quarantine has been tried, people asked if society will relax after 40 days, or however long lockdowns and social distancing will be in effect? Or will everyone turn into a mask-wearing member of the herd-despite the warning that masks (including the N95) are only partially effective?
Will life return to normal? "Sorry, but grandma's die and babies are born. So goes the cycle of life" was repeated again and again in various chats. The descriptive "We don't need to slow the spread. We need to have health organizations throw spaghetti noodles at the wall for a cure and treatment until one sticks" [5]

Problem solution
The anticipatory perspective as complementary to deterministic medicine is the alternative-a new Cartesian revolution [6]. But it is not as comfortable as the beaten path of physics and its promise for technology. It took over