Clinical Study of the effects of Immutonic capsule in human volunteers with flu symptoms

Introduction: Many herbs and natural food materials have been historically recognized as an effective panacea that can establish a balanced infl ammatory response and promoting healthy immune response as well as have antibacterial and viral effects. The clinical use of some medications can cause serious side effects. We proposed that natural ingredients could serve as a better therapeutic approach. Objective: The study aimed to evaluate the effect of IMMUTONIC capsule in human volunteers with fl u symptoms. Methods: Twenty-four male and female adult volunteers, aged between 21 and 60 years were selected for the study. Study design: The study has a randomized clinical trials for one week. Volunteers were taken IMMUTONIC capsule three times daily after meal for one week. Improving of Flu symptoms were follow up after 3 days and 7 days using improving health scale 0-5. Results: fl u symptoms and appetite were signifi cantly improving after 3 days of follow up at p <0.05 , while after 7 days were highly signifi cant improving health at p < 0.05. Conclusion: The present study indicated that Immutonic capsule improves Flu symptoms via improved immune system and its antibacterial & viral effects as well as increased appetite which lead to good feeding. Research Article Clinical Study of the effects of Immutonic capsule in human volunteers with fl u symptoms Hussien O Alkadi1*, Mohamed HK2 and Taha HK3 1Sana’a University, Faculty of Medicine and Health Sciences, Sana’a, Yemen 248 Model Hospital, Sana’a University, Yemen 3Hodiedah University, Faculty of Clinical Pharmacy, Hodiedah, Yemen Received: 11 June, 2020 Accepted: 25 June, 2020 Published: 26 June, 2020 *Corresponding author: Dr. Hussien O Alkadi, Professor, Sana’a University, Faculty of Medicine and Health Sciences, Sana’a, Yemen, Tel: 711114951; E-mail:


Introduction
Many food ingredients like Nigella sativa seed have been historically recognized as an effective panacea that can establish a balanced infl ammatory response and promoting healthy immune response as well as have antibacterial and viral effects. Garlic, ginger and black pepper are used as food supplements in India during the time of infectious diseases.
Literature shows that they have antiviral and anti-infl ammatory effects [1]. Many studies showed both prophylactic and curative effects against Chicungunya during the epidemic in Kerala form 2006-09. Antiviral [2] and stimulate immune cells such as T and Natural killer cells and macrophages effects [3], of garlic, antiviral, anti-infl ammatory [4] and related effects of black pepper [5], anti-infl ammatory [6] and anti clotting effects of ginger [7], have been reported by many workers.
These principles are known as nutritional food supplements or nutraceuticals that give protection to our body from many diseases. Therefore these and related food materials. have medicinal potential and they form the common ingredients for the indigenous system of medicines in India, Yemen, China and else where. More than 199 countries worldwide are affected by a new coronavirus disease (COVID-19) caused by infection with SARS-CoV-2gh21. The transition from early symptoms to Acute Respiratory Distress Syndrome (ARDS) is most likely due to uncontrolled cytokine release. There is an urgent need to identify safe and effective drugs for treatment. However, the clinical use of some medications can cause serious side effects [8]. We proposed that natural food supplements like that could serve as a better prophylactic , boosting immunity and therapeutic approach.

Study design
The study has a randomized clinical trials for one week.
Volunteers were taken IMMUTONIC capsule three times daily after meal for one week. Improving of Flu symptoms were follow up after 3 days and 7 days using improving health scale 0-5. Statistics Scores for the fl u symptoms before and after treatment were compared using the paired t-test. Differences were considered signifi cant when P values were less than 0.05.
All data were analyzed with SPSS statistical software.

Results
As shown in table fl u symptoms and appetite were signifi cantly improving after 3 days of follow up at p <0.05 , while after 7 days were highly signifi cant improving health at p < 0.05 Table 1.

Discussion
Infl uenza virus is capable of causing respiratory diseases worldwide. This virus is constantly evolving and new antigenic variants give rise to epidemics and pandemics. Infl uenza virus is unique among respiratory tract viruses because of its considerable antigenic variations. These mutations make it extremely diffi cult to develop effective vaccines and drugs against the virus [9]. Therefore it is an essential need to use some of the traditional medicines and combine the modern drug to inhibit the viral activity [10].
The present study shows that Immutonic capsule signifi cantly improves Flu symptoms after 3 and 7days as well as signifi cantly improves appetite.
H O. Kadi [11] reviewed that garlic, onions, black bean, ginger, black and green pepper, which have an anti-virus effect [12][13][14][15].  principles have been attributed to its poly sulfi des which react with -SH groups free radicals and also stimulants immune cells such as T and Natural killer cells and macrophages.
Ginger contains many terpenes and their derivatives such as zingiberene,beta-bisabolene, sesquiphellandrene, gingerol, zingerone and shogaols. Black pepper contains terpenoids like alpha-pinene, sabinene, beta caryophyllene, delta-3-carene, limonene and beta pinene. In addition to these, it contains an alkaloid piperine also. These principles are known as nutritional medicines or nutraceuticals that give protection to our body from many diseases. Therefore these and related spices have medicinal potential and they form the common ingredients for the indigenous system of medicines in India, China and else where [25][26][27][28][29].

Conclusion
The present study indicated that Immutonic capsule improves Flu symptoms via improved immune system and its antibacterial & viral effects as well as increased appetite which lead to good feeding and used as better prophylactic , boosting immunity and therapeutic.