Recent Hearing Loss and Earache due to Bilateral Otitis Media associated with SARS-CoV-2 infection

Background: Since the outbreak began in late December 2019, COVID-19 has been declared a global pandemic, with over 3 million cases reported worldwide. COVID-19 is known to present commonly with symptoms such as fever, cough, shortness of breath, myalgias, loss of sense of taste and smell. Otalgia and hearing loss have been reported very rarely. We present a case of upper respiratory tract infection with involvement of the sinuses and middle ear secondary to SARS-CoV-2 infection.


Introduction
Since the outbreak began in late December 2019, coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a global pandemic by the World Health Organization (WHO) on March 11,2020, with over 3 million cases reported worldwide [1]. The novel coronavirus is closely related to the previous Severe Acute Respiratory Syndrome (SARS) coronavirus epidemic in China in 2002 and the Middle East Respiratory Syndrome (MERS) in 2012 in Saudi Arabia [2,3]. Prior coronavirus epidemics in 2002 and 2012 presented with predominantly with lower respiratory tract symptoms such as cough, shortness of breath and fever and could progress rapidly to acute respiratory distress syndrome (ARDS). SARS-CoV-2 infection has been found to present commonly with both lower respiratory tract symptoms such as fever, cough, shortness of breath, ARDS as well as upper respiratory tract symptoms such as loss of sense of taste and smell [4]. Otalgia and hearing loss have been reported very rarely [5]. We present a case of upper respiratory tract infection with involvement of the sinuses and middle ear secondary COVID-19 infection due to SARS-CoV-2. smell [4,7]. Involvement of the middle ear and sinuses from upper respiratory tract infection with SARS-CoV-2 has been previously reported in a very small number of case reports [5].

Case report
Coronavirus disease 2019 (COVID-19) is usually transmitted from person to person through respiratory droplets and human body fl uids. The main harboring sites are the nasopharynx and the oropharynx. In our patient, SARS-CoV-2 infection was confi rmed by reverse transcription-polymerase chain reaction (RT-PCR) testing from nasopharyngeal swabs.
Viruses commonly cause upper respiratory tract disease inducing an infl ammatory response which leads to mucus secretions and ciliary damage to the ciliated columnar epithelium in the middle ear, eustachian tubes and sinuses (8,9) .These events lead to otitis media and sinusitis and are commonly caused by influenza virus, rhinovirus, adenovirus and parainfluenza viruses. Maxillary and ethmoid sinuses are commonly affected in such cases with rare involvement of sphenoidal and frontal sinuses. Frequently, the CT scans of patients are abnormal with viral upper tract infections. Symptoms and radiologic fi ndings spontaneously resolve in most cases. The clinical fi ndings and radiology in the present patient demonstrated that infection due to SARS-CoV-2 can lead to co-infections involving the sinuses and middle ear, similar to other viruses with gradual spontaneous resolution.
Ear, nose and throat examination is considered to be in very close proximity to the mucosal surfaces of the upper aerodigestive tract and thus all medical staff must take the necessary personal protective measures such as N-95 Face mask, face shield and gown and gloves while examining patients suspected of having COVID-19 [10,11].

Conclusion
COVID-19 most commonly presents with fever and respiratory symptoms, including cough, shortness of breath, anosmia, hyposmia, dysgeusia and sore throat. Involvement of the ear and sinuses from upper respiratory tract infection with SARS-CoV-2 has been previously reported in very small number of case reports. We are presenting this case because we believe these fi ndings should possibly alert clinicians to suspect SARS-CoV-2 infection and take proper protective measures to prevent the spread of infection.

Authors contributioSahrish Ilyas -Conception and
design, Acquisition of data, Analysis and interpretation, , Drafting the article, critical revision and fi nal approval of article, agreement to be accountable for all aspects of the work.
2. Samba Siva R Bathula -Acquisition of data, Analysis and interpretation, critical revision and fi nal approval of article, agreement to be accountable for all aspects of the work.

Funding disclosure
This research did not receive any specifi c grant from funding agencies in the public, commercial, or not-for-profi t sectors.