Non-Opioid Otolaryngology Medical Practice

Opioids have been used as pain medications in the United States since the late 1990s. Since then, opioid pain medication prescriptions increased exponentially after pharmaceutical companies informed medical practitioners that opioids were not addictive pain medications. There have been 42,000 deaths related to opioid overdoses in 2016 in the US, and 40% of the opioid overdose deaths involved prescription opioids [1]. Based on a signifi cant number of opioid-related deaths, the US Department of Health and Human Services (HHS) declared a public health emergency and announced a fi vepoint strategy to combat the opioid crisis on October 26, 2017 [2]. As an otolaryngologist, the author previously prescribed a remarkable amount of opioids for his patients’ postoperative pain management. After the HHS declaration, the author switched from opioids to non-opioids without any notable reported pain concerns from his postoperative patients [3]. Abstract


Introduction
Opioids have been used as pain medications in the United States since the late 1990s. Since then, opioid pain medication prescriptions increased exponentially after pharmaceutical companies informed medical practitioners that opioids were not addictive pain medications. There have been 42,000 deaths related to opioid overdoses in 2016 in the US, and 40% of the opioid overdose deaths involved prescription opioids [1]. Based on a signifi cant number of opioid-related deaths, the US Department of Health and Human Services (HHS) declared a public health emergency and announced a fi vepoint strategy to combat the opioid crisis on October 26, 2017 [2]. As an otolaryngologist, the author previously prescribed a remarkable amount of opioids for his patients' postoperative pain management. After the HHS declaration, the author switched from opioids to non-opioids without any notable reported pain concerns from his postoperative patients [3].
The primary purpose of this article was to demonstrate how much narcotic in Morphine Milligram Equivalents (MME) was prescribed per month by the author according to Michigan Prescription Monitoring Program (PMP) Prescriber Activity Reports (PAR) before and after 2018 for management of pain in his otolaryngology postoperative surgical patients. The author intends to actively discourage the use of opioid pain medications for routine otolaryngology procedures and to instead use acetaminophen with or without Nonsteroidal Anti-Infl ammatory Drugs (NSAIDs) to improve patient care. was deemed to be Institutional Review Board (IRB) except by not including patient specifi c information. t-Test: Two-Sample Assuming Unequal Variances statistical method was used to analyze the data and notable fi ndings were highlighted in table format in the following sections.

Material and methods
The author of this paper is referred to as the primary author. The term similar prescriber (SP) is defi ned as a prescriber that has the same role (e.g., physician, dentist, nurse practitioner) and the same healthcare specialty (e.g., internal medicine, pain management, oncology).
The author's pain medication regimens are as follows. Prior to 2018 and the HHS declaration, the author primarily prescribed one of the following pain regimens: Tylenol with Codeine #3 (acetaminophen 300 mg/codeine phosphate 30 mg) every six hours, Norco (hydrocodone and acetaminophen at 5.0/325, 7.5/325, or 10/325 mg) every six hours, or tramadol. After 2018 and the HHS declaration, the author shifted to prescribing either acetaminophen (500 mg) every six hours, for fi ve to 10 days and diclofenac (50 mg) every 12 hours for fi ve days, or ibuprofen (600 mg) three times daily for fi ve days.
The primary endpoints of this investigation were two-fold: (1) to identify and quantify the monthly narcotic prescribing patterns in MME preceding and following the implementation of the HHS based on the PMP PAR. (2) Compare and contrast this to Similar Prescribers (SP) meeting the same criteria described in the aforementioned fashion. Table 1 depicts narcotic prescriptions before and after 2018 resulting in 16.45 prescriptions per month relative to 6.9 prescriptions per month by SP within the same specialty (p=3.7). Following the HHS declaration, the author's narcotic prescriptions were remarkably lower relative to the SP group (1.5; 10.16) (p=1.8).

Results
When looking at prescriptions by MME (Table 2). No notable difference were found in MME values from 0-50 before and after the HHS declaration among the author and SP groups. However, a notable decrease, although, not statistically signifi cant (p=1.79) in MME for values in the 51-90 range among all groups after the HHS declaration.
Opioid treatment duration is outlined in Table 3. Prior to 2018, the authors mean prescriptions were 6.29 compared to 55.54 prescriptions from SP's (p=2.49). Following the HHS declaration, the author's prescriptions for longer than seven days signifi cantly dropped (90; 84.02); compated to SP's. Prescriptions for fewer than seven days went up for all two groups after the HHS declaration.
The author prescribed a notable amount of oxycodone and hydrocodone medications prior to the HHS declaration. The number of these prescriptions dropped notably after the HHS declaration, as shown in Table 4. At the same time, no notable change in opioid prescriptions in the SP group were seen even after the HHS declaration. There was no remarkable change in number of authors surgical procedures even after the HHS declaration, as illustrated in Figure 1.

Discussion
Management of perioperative pain is a medical conundrum and misuse or improper narcotic prescribing has been lead to prolonged rehabilitation, development of chronic pain, and reduced quality of life scales [4,5]. The effectiveness of      opium's ability to ameliorate pain has been used for decades.
Opioids trigger a release of dopamine, stimulating the brain by occupying pain receptors. This leads to a cascade of receptor downregulation and an initial feeling of euphoria for patients prior to the amelioration of pain. The opioid epidemic is a serious health problem in the US at present. Overdoses caused more than 47,000 deaths in 2017, and 36% of those deaths involved prescription opioids [1]. On average, 130 Americans die every day from an opioid overdose [6]. The author did not notice any remarkable uncontrolled postoperative pain concerns from surgical patients after switching to non-opioid pain medications, which explain why his narcotic prescriptions were signifi cantly lower in the PMP report after 2018. Additionally, the author performed almost the same number of surgeries mentioned above before and after 2018. At present, the author is prescribing opioid pain medications only to renal and head-neck malignancy patients.
After analysis, it was noted that the PMP reports indicate the SP group was still prescribing a large amount of opioid pain medications. It was also noted in a recently published article that opioids remained the primary modality for postoperative tonsillectomy pain management [13]. If ear-nose-throat surgeons keep prescribing narcotic pain medications, we are not helping society to curb the opioid epidemic. The main intention of this paper is to discourage the use of opioid pain Multi-center, randomized, prospective controlled trials on acetaminophen and NSAID pain medication use in these cases are needed.

Conclusion
The opioid epidemic is causing signifi cant mortality in the US; most of this originates from prescription opioids. The author discourages the use of Opioid pain medications for routine otolaryngology procedures and herein demonstrates the effective use of acetaminophen with or without NSAIDs (ibuprofen and diclofenac) to improve patient care.