Transient camptocormia with citalopram treatment in a patient with mixed dementia–A case report

Camptocormia, or “bent spine,” is an involuntary fl exion of the spine that is exaggerated while standing or walking but diminished when supine. It was described in the medical literature between the years 1917 and 1928 [1,2]. Soldiers who spent time in the trenches during World War I continued walking in a bending position even after the war was over. The phenomenon was considered “a war neurosis” [3]. Today, camptocormia is mainly regarded as a symptom of Parkinson’s disease, described as a forward bended prominent posture while standing or walking [4]. The mechanism is considered to be associated with dystonia or paravertebral muscle myopathy [5]. Additional medical conditions presenting with camptocormia include Alzheimer’s disease [6], parietal lobe ischemia [7] and bipolar disorder [8]. Certain medications, such as sodium valproate and olanzapine, have been suspected to induce camptocormia [9-11]. Here we present a patient who experienced severe transient camptocormia with the induction of citalopram treatment. To our knowledge, camptocormia has not been described as a side effect of Selective Serotonin Reuptake Inhibitors (SSRI’s) as a class or of citalopram specifi cally.


Introduction
Camptocormia, or "bent spine," is an involuntary fl exion of the spine that is exaggerated while standing or walking but diminished when supine. It was described in the medical literature between the years 1917 and 1928 [1,2]. Soldiers who spent time in the trenches during World War I continued walking in a bending position even after the war was over.
The phenomenon was considered "a war neurosis" [3]. Today, camptocormia is mainly regarded as a symptom of Parkinson's disease, described as a forward bended prominent posture while standing or walking [4]. The mechanism is considered to be associated with dystonia or paravertebral muscle myopathy [5]. Additional medical conditions presenting with camptocormia include Alzheimer's disease [6], parietal lobe ischemia [7] and bipolar disorder [8]. Certain medications, such as sodium valproate and olanzapine, have been suspected to induce camptocormia [9][10][11]. Here we present a patient who experienced severe transient camptocormia with the induction of citalopram treatment. To our knowledge, camptocormia has not been described as a side effect of Selective Serotonin Reuptake Inhibitors (SSRI's) as a class or of citalopram specifi cally.

Case
A 70-year-old retired sculptor was admitted to a dementia special care unit due to severe cognitive impairment and tendency to wander around aimlessly. According to his family, the cognitive impairment began 5 years earlier. Memory and visuospatial functioning were the fi rst domains to be affected.
Severe worsening of the cognitive impairment and behavioral symptoms began near the time of a cardiac pacemaker insertion. The patient was seen crawling on the fl oor, looking for objects that were not there. When questioned, he could not explain why, and so the behavior was attributed as a reaction to visual hallucinations. Brain imaging supported diffuse vascular disease. Apart from mixed dementia, his medical history included ischemic heart disease, sick sinus syndrome and permanent pacemaker.

Abstract
This case report reviews a patient who suffered mixed dementia with depression. The addition of citalopram to the medication regimen was shortly followed by the manifestation of camptocormia, or "bent-spine." Clinical fi ndings available, without attempting invasive diagnostic procedures, point to a citalopram induced camptocormia. The frequent use of SSRI medications in the geriatric population call for an increased awareness of the possibility of SSRI induced postural side effects.

Discussion
As previously mentioned, camptocormia is thought to be a result of either dystonia or focal myopathy of the paravertebral muscles [5]. Determining a myopathic mechanism requires invasive diagnostics such as an EMG and muscle biopsy.
In general, we try to avoid or postpone invasive diagnostic procedures for patients with advanced dementia until after all non-invasive methods have been attempted to reach a diagnosis. Therefor it was fi rst attempted to remove the newest It is relatively common for patients with degenerative brain diseases whom are diagnosed with depression to be treated with various SSRI medications [12]. However, most do not experience this symptom. The question arises as to whether and why this patient was prone to develop this phenomenon. The medical condition most frequently associated with camptocormia, Parkinson's disease, was not part of the patient's medical history. Although the medication regimen included haloperidol when citalopram was initiated, camptocormia did not occur with haloperidol alone, nor with risperidone, which the patient received in the past. Use of donepezil has been cited in the literature associated with "pisa syndrome", another type of postural abnormality characterized as a lateral fl exion of the trunk [13]. Like the other medications, the patient had been taking donepezil for a long time. Although this supports the assumption that citalopram was the trigger of the camptocormia, it leaves the possibility that it was not the only pharmaceutical factor.
Another possible contributing factor may be the patient's profession. Working as a sculptor exposed him to spending hours a day in a bending position. Theoretically, this may resemble a "task specifi c dystonia," contributing to a dystonic mechanism in the development of camptocormia.
We suggest addressing the bending posture as a range of severities from normal age-related bending to the extreme posture of camptocormia, instead of an "all or none" phenomenon. It is possible that an accumulation of factors increases the risk of developing bent spine, such as neurological diseases, medications, genetic predisposition and even physical fi tness.
Camptocormia may have a major impact on the quality of life of older persons, as walking with a bent spine may lead to functional decline and increased risk of falling. In addition, a patient with camptocormia may suffer from low self-esteem that may induce or worsen social isolation and depression.

Conclusion
Although we describe citalopram induced camptocormia, we suggest increasing awareness to the possibility that this may be a side effect of other SSRI medications. Given the high prevalence of depression in the geriatric population, and the high frequency of SSRI use, one might consider reducing the dose or switching to another anti-depressant. SSRIs are known to increase the risk of falls. If the bending posture is a range from normal aging to clinical camptocormia this may be a possible mechanism by which SSRI medications worsen stability and increases the risk of falling. This case report may contribute to increasing awareness of camptocormia and its possible relation to SSRI treatment.