History of depression through the ages

Depression is often presented as a fashionable disease. It is considered to be the disease of the 21st century. Yet it was already described by Hippocrates in antiquity and it was at the beginning of the 1800s that this term of depression, of the Latin "depressio" meaning depression, will make sense with the birth of psychiatry. From this distant period to the present day, it is possible to discover the long journey which is a fact of depression, a well-defi ned clinical entity. The aim of this article is to follow the concept of depression through the ages, from ancient times to the present day; to see how it was built.


Introduction
Depression is often presented as a fashionable disease. It is considered to be the disease of the 21st century. Yet it was already described by Hippocrates in antiquity and it was at the beginning of the 1800s that this term of depression, of the Latin "depressio" meaning depression, will make sense with the birth of psychiatry. From this distant period to the present day, it is possible to discover the long journey which is a fact of depression, a well-defi ned clinical entity. The aim of this article is to follow the concept of depression through the ages, from ancient times to the present day; to see how it was built.

Greco-Roman antiquity
Hippocrates Melancholy has been known since Antiquity and described as such: "If fear and sadness last a long time, such a state is melancholy," writes Hippocrates in his book Aphorisms [1]. Indeed, Hippocrates, a Greek physician, is considered the fi rst physicist to describe melancholy or depression clinically. In the 5th century BC, Hippocrates founded the theory of moods. According to this theory, the body contains four moods that each determines our temperament. The four moods are [2].
-blood: produced by the liver and received by the heart (blood type) -the phlegm or phlegm or lymph attached to the brain (lymphatic character) -yellow bile coming from the liver (bilious character, that is to say anxious) -the black or atrabile bile coming from the spleen (melancholic character) These moods correspond to the four elements themselves characterized by their own qualities: -fi re: hot and dry -air: hot and humid -the earth: cold and dry -water: cold and wet The sanguine, the one in whom blood predominates over other moods, is in a happy mood.
The phlegmatic (air) is said of the calm and imperturbable man who keeps his cold and almost apathetic.
The bilious (fi re) is an inclined to anger.
The atrabilist is the one that a black bile makes sad and sorrowful.
The notion of melancholy is therefore very old and holds its place within these four temperaments [3]. Until rebirth, melancholy (mêlas= noir and chole= bile in Greek) will be considered as a disease caused by an excess of black bile in the body. We fi nd this use in expressions like "to make bile" or "to make a blood of ink". The spleen is the organ responsible for this disorder (while current medicine sees the organ of immune defenses). Its psychic origin will be recognized only from the 18th century. It is especially to one of these disorders that Hippocrates is interested: the melancholy or "spleen" signifying the "spleen", "the bad mood". He inspired Baudelaire a French poet, who later wrote "the fl owers of evil" by drawing his ideas from this theory [4], Figure 1. in the nineteenth century. Conversely, when a mood is lacking, it can be remedied by appropriate food or exercises (walking, massage).
Aristotle (384-322 before BC) The melancholic temperament summarized at the time to the symptoms that go from fear to anxiety, misanthropy and constant despondency, is an idea that, once again, goes back to Hippocrates and more specifi cally to the problems attributed to Aristotle where it is more clearly explained.
In the famous problem, called "Problem XXX, 1" [6], Aristotle explains that there are two kinds of melancholy: natural melancholy and pathological melancholy.
This Greek philosopher associate's melancholy with imagination and therefore indirectly with genius. Melancholy is for him, a perfect oscillation between genius and madness. As a result, the great men (philosopher, artist, poet) are melancholic with a complex mixture of astonishment and skepticism. The author of this "problem" thus observes and understands this "tragic anomaly of the exceptional man, between exaltation and overwhelming depression". He wonders, "Why were all the exceptional men of the past, in philosophy, politics, poetry, or the arts, manifestly melancholy?" Dark mood is recognized for developing "the unmanageable faculties of the imagination ".
Melancholy can therefore be associated with a pathology, or on the contrary, with the sign of genius, depending on what will be privileged between the illusions of imagination and creativity.
According to Aristotle: "There is no genius without a grain of madness" [7]. Finally, he distinguishes two psychopathological charts. On one side, we fi nd the quiet madness caused by an excess of cold black bile resulting in states of unconsciousness, euthymia and dysthymia. On the other side, there is the agitated madness due to an excess of hot black bile causing mania, the subjects are impulsive and angry.
Galen (129-201) The name of melancholy has been imposed on this species of madness because according to Galen, Greek physician of antiquity, the sad moral affections depend on the bile which, become black, darkens the animal spirits and makes delirious [8].
Areteo of Cappadoce (2nd century AD) The fi rst written descriptions of a relationship between mania and melancholy are established before the Christian era by Areteo of Cappadocia.
This Greek doctor insists on the character of hyper-religiosity, guilt and sacrifi ce of the melancholic. Hippocratic thought distinguishes several nosological entities some of which will continue: frenzy, lethargy, mania or melancholy. Frenzy and lethargy result in acute madness with fever. Mania and melancholy, meanwhile, correspond to two chronic follies without fever: mania with excitement and melancholy with depression [9].

Middle ages
From the 4th century, the Christian hermit movement will highlight the dangers of melancholy. The anchorites are Christians who decide to live in solitude and for that they retire After the theory of the four moods which had its full development with Hippocrates at the end of the fi fth century and beginning of the fourth century BC [5] and recovery then reinforced centuries later, including Galen, doctor and philosopher of the times that followed. Through the Middle Ages and the Renaissance, these people speculated on the four temperaments that result from these moods and their correspondence with the four ages of man. There was talk of a "sanguine" youth, a "choleric" maturity (up to 40 years), a "melancholy" period (40 to 60 years) and a "phlegmatic" old age.
Melancholy therefore immediately has its place as a typical temperament. The major symptoms are fear and sadness.
Treatments are studied to restore balance and diets to maintain it. We can correct the excessive coldness of the old men by offering them a little wine, but the excessive heat of young to the desert to break with a society they consider in perdition.
In this isolation, one of the dangers that threatens them is acedia. The acedia is, initially, a discomfort linked to the excess of deprivation which seizes the monks [10]. This term means "negligence", "grief", "indifference". By seizing this symptom, which among the desert monks is rather psychic discomfort than "evil", Christians turn it into emissions of evil and evil thoughts. It becomes the most formidable temptations in connection with the demon and the moral fault. Acedia becomes a divine punishment. It will haunt the monasteries of the West but also the secular society until the end of the Middle Ages.

Renaissance (16 th century)
From the 16th century, the nascent humanism will restore to honor the previous reasoning of Aristotle for which the melancholic is primarily a man of genius. Faced with questioning, with knowledge, with metaphysical refl ection, man is melancholy. "The Renaissance," said Starobinski, "is the golden age of melancholy" [11]. Such an assertion may seem with great coherence the four great human temperaments according to the predominance of this or that mood . The melancholy temperament predisposes individuals to be "sad, annoying, fi rm, severe and harsh, envious and shy".

The classical age (16 th -18 th century)
In the classical age stretching from the completion of the Renaissance to the end of the Enlightenment, there is a new reversal: melancholy is considered an alienation of the imagination. It must be fought with reason, irony. Melancholy becomes a disease. Mental pathology takes place in medicine with the appearance of institutions some of which will claim the specifi city. There is no longer one but "some" melancholy.
His representations multiply: vanities of earthly goods, vanity of knowledge, of philosophical refl ection, of art itself [12].
The melancholy par excellence is a person weakened by the absence of meaning, meanings of things, emptiness.
Nevertheless, it is possible to fi ght against this pathology by the desire to control reason.

Robert Burton (1577-1640)
The " Anatomy of Melancholy" published in 1621 by Robert Burton [13], a teacher and vicar at Oxford, has a great infl uence on the ideas concerning this disposition of the mind. He analyzes melancholy: its causes, its symptoms, its effects, the most unexpected characteristics of these manifestations, its remedies. For him, melancholy is a disease. He refuses to believe in the existence of a possible natural and non-pathological form of melancholy, that melancholy previously evoked as a natural temperament that can lead to genius. This book constitutes an important sum of all the knowledge and theories that Burton binds to mourning.
Burton proposes to make religious melancholy a species full of melancholy. It launches the kick-off of a medicalization of religious controversies that takes all its importance following the English Civil War. The Anglican orthodox criticize these ideas and present fanatics or atheists as patients suffering from a humoral imbalance. This category of religious melancholy will end up, however, by designating, in the early eighteenth century, a certain way of practicing religion but also the kind of life of the subjects who devote their existence to religion.
In this transitional period of the passage from the Renaissance to the lights, Burton is one of the fi rst to condemn this "melancholy fashion" that leads people to indulge in a state that may be a priori pleasant but that may lead to withdrawal on oneself and on madness.
"Among so many thousands of authors, you will fi nd it diffi cult to fi nd some whose reading will make you a little better; on the contrary, it will infect you when it should help to perfect you. Burton considered himself melancholic.

Birth of modern psychiatry in the early nineteenth century
Philippe Pinel (1745-1826) After the "great confi nement" of the seventeenth century seen above, a growing population is relegated to General Hospitals (crazy, vagabonds, foolish, bad women, libertines). The increase of the population in these establishments is thus considerable and those until the circular of 1785 which will be decisive for the birth of psychiatry.
"Instructions on how to govern the foolish and to work for their healing in the asylum intended for them" is a circular government where the "foolish" will benefi t from a particular confi nement. 1785 marks the beginning of the therapeutic asylum [18]. Indeed, this circular recommends not to sequester the insane, but to treat them in specialized institutions, subdivided into neighborhoods (quiet, violent lunatics, foolish fools, etc.). In this context, Pinel arrives at the hospital Bicêtre in 1793, where we receive the crazy estimated incurable, their living conditions are abominable [19].
Philippe Pinel, appointed doctor of the infi rmary in Bicêtre, meets Jean-Baptiste Pussin "governor general of the fools" who gives him a report concerning "the state of the fools entered Bicêtre since January 1, 1784 just and including the last 2) mania, where delirium is general.
3) dementia, where there is impairment of all mental faculties, generalized intellectual debility.

4) idiotism, where there is suppression of mental activity.
We can also quote William Cullen, author of the famous book "Institution of Practical Medicine", which will greatly infl uence Pinel by emphasizing the main role of the nervous system in the transmission of sensations and irritations [21].  is an alternation of mania and melancholy called "circular insanity" [24]. He developed a new form of "moral treatment"

Second half of the 19 th century
using the words of Philippe Pinel. This time, it is a "bullying", the mad must give up delirium under penalty of sanctions.

The crossroads of the late nineteenth century: 1870-1920
The theory of degeneration: The theory of degeneration opens a new page in the history of the evolution of ideas in mental pathology. The doctrine of degeneration is associated with the name Bénédict Augustin Morel (1809-1873) who popularized this term in 1857, the year of publication of his "Treatise on physical, intellectual and moral degenerations of the human species", then in 1860 in his Treaty of mental illnesses. Under the effect of debilitating infl uences of the environment, adverse social factors and negative moral factors, the individual sees his nervous system subjected to constant aggressions. The origin of these disorders constituting this mental state, according to Morel, thus fi nds its origin, either in affections acquired at a young age, or in heredity. He will illustrate these, citing intoxications and alcoholism, misery, malaria, etc. The latter could cause injuries that were at the root of the various mental disorders of which the person was a victim during his life. The individual thus found himself engaged in a "sickly deviation" leading to dementia [25].
Valentin Magnan (1835-1916) Valentin Magnan, meanwhile, separates the lunatics into two groups: the normal and the degenerate. The normal ones become sick, maniac, delirious or melancholic under the effect of various causes but of great intensities. In return, the degenerates present a primitively troubled mentality which, for a commonplace cause, will present great troubles. We observe in this category the lower degenerates (idiots and imbeciles) or the average ones (the morons) with weak moral and intellectual faculties and marked brain lesions, and the higher degenerates with a disharmonious moral and intellectual development explained by a dissociation of the centers: psychic and motor [26].
Emile Kraepelin (1856Kraepelin ( -1926) Emile Kraepelin is a prominent clinician from a period when German psychiatry is at its peak. From his point of view, the essential lies in the careful observation and the clinic [27]. In his "Introduction to Clinical Psychiatry" (1907), he carries out a varied classifi cation of depressive states. At the head of the chapters, one fi nds successively: melancholy, depressive circular states, catatonic stupor, manic-depressive mixed states, catatonic excitation ... The categories multiplied according to the alternation or the permanence of the episodes and according to their duration [28]. His defi nition of melancholy brings together the different elements that psychiatry of the time had noticed: "The syndrome of melancholy is characterized by the insensitive development of anxious depression, to which delirious conceptions are joined in very variable proportions" [29]. The most common are guilt ideas. At other times, hypochondriac ideas dominate the picture. Finally, it may be the fear of becoming poor, starving, going to jail, being judged, etc. Gradually anxiety becomes so great that the sick want to die, and very frequently indeed, they commit suicide. » It brings together, on the one hand, the vast majority of delusional disorders under the name "early dementia", a term that emphasizes a terminal disturbance of intellectual faculties. On the other hand, and symmetrically, he creates a set that he will call "manic-depressive illness", whose fundamental disorder does not concern the intellectual but he proposes an analogy between melancholy and the work of mourning. In short, the self identifi es with the lost object to the point of losing itself in the infi nite despair of an irremediable nothingness " In 1915, he published "Mourning and Melancholia" [31], founding text for psychoanalysis of the theory of melancholy. In fact, to a certain extent, what happens in the melancholy crisis is entirely like the loss suffered by the death of a loved one. A painful state of mind, a lack of interest in the outside world as well as the inability to choose a new object of love and in general the abandonment of any social activity characterizes the mourning. With one exception, the loss to which the melancholic reacts is unconscious, and is not directly related to a real loss as in mourning. The only difference between mourning and melancholy is thus manifested by the presence, in the last, of a deprecating attitude towards one's own self, which goes as far as "delirious" forms of violence, among which suicide remains the most radical. This trait manifests itself through the discourse of the subject suffering from depression and is most often realized by complaints that the analyst must not reject. For Freud, the melancholy has made the objectual disinvestment, but the quantity of libido remains intact and affi xed to the ego, which then becomes the lost object. The melancholy thus regresses to narcissistic identifi cation, becoming its own object, and privileging the side of hatred: it can explain self-reproaches.

Psychoanalysts Sigmund Freud, Karl Abraham and Melanie
Klein defi ne depression as the result of a psychic confl ict (oedipal or narcissistic) and not as the passive carrier of a disease to heal. For Freud, it is a question of resolving the repressed confl ict by analyzing the resistances, so that the patient fi nds the freedom to decide for this or that thing [32].

Symptoms of depression nowadays
Nowadays the diagnostic criteria for the major depressive episode are listed in ICD-10 (International Classifi cation of Diseases, 10th Edition) [33]  The different types of depression in the 21st century [34] Dysthymia: To be able to speak of a diagnosis of "dysthymia", you must observe at least two of the symptoms of depression. It is a very common form of depression. Minor depression is depression that can affect anyone. We talk about depression, but it is less severe than other forms of depression. The symptoms of depression that manifest with this form of depression are the common symptoms of depression. You can fi nd these symptoms in the symptoms of depression section or in the main article on depression. The maximum number of symptoms of depression observed for this form of depression can amount to 4 symptoms. If this criterion is exceeded, we speak of a more serious form of depression. Dysthymia is therefore a mild form of depression because there are only a limited number of symptoms of depression. This is not to say that the person's subjective suffering cannot be treated as much or at all. Although this is a milder form of depression, you can effectively combat your suffering and symptoms of depression. The milder the symptoms, the sooner you seek treatment, the sooner you will see the effect of this treatment.

Major depression:
In order to speak of a diagnosis of major depression, one should observe between 5 and 9 symptoms of depression. This form of depression is also common. It may be one of the lesser known forms of depression when it is often encountered. Research indicates that more than 17% of the world's population suffers from major depression during their lifetime (D. G Blazer and R. C. Kessler, 1994). The symptoms that should be observed for this form of depression are the common symptoms that are spoken of in the event of depression. You can fi nd these symptoms in the symptoms of depression section or in the main article on depression.
When it comes to major depression, the known symptoms of depression appear for a single period for at least two weeks. A major depression is therefore a single period which can last from several weeks to several years. If more than one episode occurs, this is called another form of depression.

Chronic depression:
In the case of chronic depression, the symptoms of depression appear repeatedly. This means that you are going through several depressive periods, unlike major depression. This form of depression belongs to the encompassing forms of depression. Chronic depression, however, is a lesser-known form of depression, as the most well-known forms of depression only occur once. You can fi nd common symptoms of depression also for this kind of depression. Between periods of depression, there must be a period of at least two months. During these two months, you cannot experience any symptoms of depression, otherwise it is called persistent depression.
Chronic depression is a period in which you have no symptoms of depression. After these two months, you can go through a depressed period again with the associated symptoms.

Bipolar depression:
To be able to speak of a diagnosis of bipolar depression, depressive periods must alternate with periods of high euphoria or agitation. Euphoric periods are also called manic periods. During these periods, the patient feels "king of the world" and is quickly irritated. Many people also do irrational things during manic times, such as making purchases that they cannot afford. After this manic period, the client relapses into a depressive period. During this depressive period, the client experiences several symptoms of depression in an overwhelming climate. We will therefore feel constantly sullen and depressed. These depressive periods generally last longer than manic periods. In bipolar disorder 2 the manic episodes are replaced by hypomania [35].
Other forms of depression: There are also fewer common forms of depression, such as postnatal depression [36], a form of depression that occurs after the birth of a child, seasonal depression, a type of depression that occurs primarily during a particular season, etc. These forms of depression can be linked to certain hormones, such as in the case of postnatal depression, or to the perception of light, as in the case of seasonal depression. You may then feel depressed in winter, for example, because you are not getting enough sunlight.

The revolution of neurology and neuroscience
After the revolution of nineteenth-century brainwashing with the role played by the hypothalamus, the regulating center of the needs and orders of the great metabolism, we can cite Von Economo, Vogt and Brodman, who describe the architecture of the brain by exploring the motor areas [37].
At the beginning of the 20th century, the fi rst truly effective therapies were shock methods such as insulin treatments or electroconvulsive therapy (ECT).
It is also the successes of pharmacology that have brought depression to its current dimension. If we do not know enough how to defi ne it, we at least try to cure it. Henri Laborit, Pierre Deniker and Jean Delay discover the fi rst neuroleptics in Paris in 1952, this discovery inaugurates the era of commercialization of modern psychotropic drugs. Roland Kuhn, a Swiss psychiatrist, close to psychoanalytic circles who in 1956, elaborated the antidepressant effects of imipramine [38]. The scientists are based on the study of chemical mediators whose action is at the level of neuronal synapses: acetylcholine, norepinephrine, adrenaline and dopamine, whose dysregulation (excess or depletion) could be the cause of a certain number of symptoms. psychiatric, from depression to psychotic symptoms.
These fi rst antidepressants were prescribed in the hospital mainly by psychiatrists for fear of side effects. The understanding of the brain has led to the discovery of more effective biological therapies and especially less disabling.
From the late 1980s, newer antidepressants came on the market with fewer side effects. In parallel, the development of cognitive psychology will join the progression of brain imaging techniques to gradually build the wide fi eld of neuroscience.

Brain plasticity and depression
The brain is constantly being remodeled [39]. For the links between depression, plasticity and recent events, we must briefl y talk about the mode of action of antidepressants, which are increasingly believed to have cerebral neurotrophic effects.
This means that antidepressants activate the secretion in the brain of molecules, which are peptides, whose properties are to make neurons grow (or their extensions). This would imply that there is some kind of atrophy or agenesis of certain neurons, or neuronal extensions, in the brain of the depressed, a hypothesis that not everyone shares (some researchers even believe that if antidepressants stimulate secretion neurotrophic factors, that's because they themselves have neurotoxic properties).
Electroshock also stimulates the production of neurotrophic factors, as do certain mood stabilizers, but it would be wrong to say that the neurotrophic theory of depression has now completely found its mark. There are therefore certainly in depression phenomena which fall within the framework of what is called recent plasticity, but we are always looking, on the qualitative level, for the plastic mechanisms which make that in the depressed neurotransmitters do not more optimally perform their role as activators or coordinators of the various brain structures involved in stress, and which make antidepressants capable of restoring neurotransmitters this capacity by enhancing their activity.
The links between old events and plasticity are the subject of much research. There are links between experiences of separation, or social isolation, at different stages of life, and the development of neurotransmitter systems, expression of peptides (neurotrophics and opiates), the activity of the hypothalamic axis -cortico-adrenal (HPA) and the sensitivity of central receptors to corticosteroids. It is certain that individual history, and more precisely traumatic history, that of stresses of different types, leaves imprints in the brain, and we are able today to recognize a certain number of these imprints in animal experimentation.