Profile of children with intestinal malrotation: A tertiary hospital experience in a developing country

Background: Intestinal malrotation is a congenital disorder resulting from abnormal rotation of the intestine during fetal development. The aim of this study was to evaluate our experience in the management of pediatric patients with intestinal malrotation. Materials and methods: This was a retrospective study of children aged 3 years and below who were treated for intestinal malrotation between January 2014 and December 2018 at the pediatric surgery unit of Enugu State University Teaching Hospital (ESUTH) Enugu, Nigeria. Results: Sixty-one patients had laparotomy for intestinal malrotation during the study period. There was predominance of male patients and the age range was 10 days to 3 years. Abdominal pain and upper gastrointestinal tract contrast study were the most common symptom and investigation respectively. Intestinal obstruction caused by congenital (Ladd’s) bands was the most common intra-operative fi nding and Ladd’s procedure was the most performed surgical procedure. Most patients did not develop any post-operative complications. However, surgical site infection was the most common complication following surgery. Mortality occurred in 8 (13.1%) patients. Conclusion: Intestinal malrotation symptoms occur more in males and abdominal pain is a common and consistent symptom. Upper gastrointestinal contrast study is usually diagnostic. There are morbidity and mortality associated with treatment of intestinal malrotation. Research Article Profi le of children with intestinal malrotation: A tertiary hospital experience in a developing country Chukwubuike Kevin Emeka* Pediatric Surgery Unit, Department of Surgery, Enugu State University Teaching Hospital, Enugu, Nigeria Received: 15 December, 2020 Accepted: 23 December, 2020 Published: 24 December, 2020 *Corresponding author: Chukwubuike Kevin Emeka, Department of Surgery, Enugu State University Teaching Hospital, Enugu, Nigeria, E-mail:


Introduction
Intestinal malrotation is a congenital disorder resulting from abnormal rotation and fi xation of the intestine during fetal development [1]. Intestinal malrotation is a spectrum of anomalies that ranges from non-rotation to normal positioning [2]. Depending on the position of ligament of Treitz, malrotation may be classifi ed into typical or atypical: Typical malrotation is when the ligament of Treitz is to the right of the midline while atypical malrotation is when ligament of Treitz is to the left of the midline [2]. Intestinal malrotation occurs in between 1 in 200 and 1 in 500 live births [3]. Symptoms of intestinal malrotation manifest in the early weeks of postnatal life. About 40% of malrotation is diagnosed within 1 week after birth and 75% to 85% within 1 year after birth [4]. Embryologically, intestinal rotation and fi xation of the fetal bowel occur between the 4 th and 10 th week of intrauterine life. The fi xation places the duodenojejunal loop to the left of the midline and the caecum in the right lower quadrant [5]. Variations or deviations from this normal process of intestinal development result in malrotation. Symptoms of intestinal malrotation may vary from one patient to another. In newborns, bilious vomiting is a typical presentation [6]. Older children may present with crampy abdominal pain, nausea and/or bilious vomiting [7]. An upper gastrointestinal contrast study is necessary for the diagnosis of intestinal obstruction [8].
Surgery for incidentally detected asymptomatic malrotation is controversial. In the presence of midgut volvulus and intestinal obstruction, surgery is mandatory [7]. The aim of this study was to evaluate our experience in the management of pediatric patients with intestinal malrotation.

Materials and methods
This was a retrospective study of children aged 3 years and below who were treated for intestinal malrotation between January 2014 and December 2018 at the pediatric surgery unit of Enugu State University Teaching Hospital (ESUTH) Enugu, Nigeria. ESUTH is a tertiary hospital located in Enugu, South East Nigeria. The hospital serves the whole of Enugu State, which according to the 2016 estimates of the National Population Commission and Nigerian National Bureau of Statistics, has a population of about 4 million people and a population density of 616.0/km 2 . The hospital also receives referrals from its neighboring states. Patients with incomplete medical records and those who have had previous intestinal surgery were excluded from the study. Information was extracted from case notes, operation notes, operation register, and admission-discharge records. The information extracted included age, gender, presenting symptoms, interval between onset of symptoms and presentation, investigations performed, intra-operative fi nding, defi nitive operative procedure performed, complications of treatment, duration of hospital stay and outcome of treatment. Ethical approval was obtained from the ethics and research committee of ESUTH. Statistical Package for Social Science (SPSS) version 21, manufactured by IBM Cooperation Chicago Illinois, was used for data entry and analysis. Data were expressed as percentage, median, mean and range.

Patients' demographics
A total of 65 cases of symptomatic intestinal malrotation in pediatric patients were seen during the study period but only 61 patients had complete medical records and form the basis of this report. Demographic features are shown in Table 1.

Presenting symptoms
The patients presented with symptoms in various combinations ( Table 2).

Investigations performed
All the patients had plain abdominal radiograph and abdominal ultrasound. Forty-nine (80.3%) patients had upper gastrointestinal contrast study. None of the patients had abdominal CT scan. Plain x ray showed features of duodenal obstruction in 6 (9.8%) patients, abdominal ultrasound was suggestive of malrotation in 11 (18.0%) patients. A radiological diagnosis of malrotation was made through upper gastrointestinal contrast study in 47 (47/49) (95.9%) patients.

Intra-operative fi nding and operative procedure performed
The intra-operative fi ndings and operation performed are depicted in Table 3.

Complications of treatment
Post-operative complications of the patients are shown in Table 4.

Outcome of treatment
Fifty-three (86.9%) patients recovered and were discharged home. Eight (13.1%) patients expired. The causes of death were overwhelming sepsis and extensive bowel resection resulting in short bowel syndrome. Mortality occurred in 7 neonates and 1 infant. More males died, male: female ratio (5:3). Mortality was more in patients with intra-operative fi nding of midgut volvulus. Two of the patients that died had intestinal resection while the other 6 patients presented after a mean period of 6 months from the onset of symptoms and they died from fulminant respiratory system infections. The high mortality recorded in the present study could be attributed to late    presentation. In a resource constrained environment like ours, lack of parenteral nutrition and lack of intensive care facilities for close monitoring of patients may also responsible.

Discussion
The fi rst reports of intestinal malrotation were surgical and autopsy fi ndings. The fi rst description of the embryologic process of intestinal rotation and fi xation was published in 1898 [9]. In 1923, Dott described the relationship between embryologic intestinal rotation and surgical treatment [10].
In 1936, William Edward Ladd wrote the classic article on treatment of malrotation. His surgical approach, Ladd's procedure, remains the cornerstone of the treatment of intestinal malrotation [11]. The clinical signifi cance of intestinal malrotation is duodenal obstruction and midgut volvulus.
In the present study, there is male predominance. This is consistent with the report of other authors [12,13] [19]. Another study documented that up to 80% of their patients were neonates [20]. The predominance of neonates in intestinal malrotation may be explained by the congenital nature of intestinal malrotation. The duration of hospitalization of our patients is comparable to the report of Ooms, et al. [21].
Post operatively, the length of time patients with malrotation stay in the hospital may depend on the modality of treatment and extent of the operative procedure performed. Laparoscopic treatment is associated with reduced period of hospitalization [21].
Abdominal pain was the most common and consistent symptom in our patients. Other series on malrotation also reported abdominal pain as the most common symptom [14,17].
The abdominal pain may be chronic and crampy due to partial intermittent intestinal obstruction or may be severe and acute in cases of midgut volvulus [22]. Non-specifi c symptoms such as vomiting, diarrhea, bloating, dyspepsia and early satiety have been reported in patients with intestinal malrotation.
Some patients have been labeled as having functional or psychiatric disorders [23].
In cases of duodenal obstruction by Ladd's band, the double bubble sign is seen on plain abdominal radiograph. This double bubble sign was observed in one-tenth of our patients and is produced by an enlarged stomach and proximal duodenum.
About one-fi fth of our patients had reversal of the relationship between superior mesenteric artery and vein (Whirlpool) sign.
This sign is mostly seen in midgut volvulus due to the twist of the superior mesenteric vessels. The upper gastrointestinal series is the criterion standard required for the diagnosis of intestinal malrotation [24]. The high sensitivity of upper gastrointestinal series reported by other studies is in line with the report of the present study [24,25]. Majority of our patients did not develop any complications.
Surgical site infection was the most common complication in the current series. Other studies also recorded surgical site infections following surgery for malrotation [15,27]. The incidence of wound infection is less in laparoscopic surgery than in open surgery [28]. As recorded in one of our patients,

Conclusion
Intestinal malrotation symptoms occur mainly in males and abdominal pain is a common and consistent symptom. Upper gastrointestinal contrast study is usually diagnostic. There are morbidity and mortality associated with the treatment of intestinal malrotation. Early presentation and referral is recommended for patients with symptoms suggestive of intestinal malrotation to avoid bowel gangrene.