Introduction: The repair of peripheral nerve injuries is still one of the most challenging tasks and concerns in neurosurgery. Effect of cyclosporin (CsA) loaded silicon conduit as an in situ delivery system of CsA in bridging the defects was studied using a sciatic nerve regeneration model in diabetic rats.
Methods: A 10-mm sciatic nerve defect was bridged using a silicon conduit (SIL/CsA) filled with 10 μL carrier-drug dilution (10 ng/mL CsA). In control group (SIL), the conduit was filled with the same volume of the phosphate buffered solution. The regenerated fibers were studied 4, 8, 12 and 16 weeks after surgery.
Result: The functional and electrophysiological studies confirmed faster recovery of the regenerated axons in CsA treated than control group (P < 0.05). The mean ratios of gastrocnemius muscles weight were measured. There was statistically significant difference between the muscle weight ratios of SIL/CsA and SIL groups (P<0.05). Morphometric indices of regenerated fibers showed number and diameter of the myelinated fibers in SIL/CsA were significantly higher than in control group.
Conclusion: Cyclosporin when loaded in a silicon conduit resulted in improvement of functional recovery and quantitative morphometric indices of sciatic nerve in diabetic rats.
Keywords: Peripheral nerve repair; Sciatic; Cyclosporin A; Local diabetes
Published on: May 16, 2015 Pages: 19-26
Full Text PDF
Full Text HTML
DOI: 10.17352/2455-4634.000004
CrossMark
Publons
Harvard Library HOLLIS
Search IT
Semantic Scholar
Get Citation
Base Search
Scilit
OAI-PMH
ResearchGate
Academic Microsoft
GrowKudos
Universite de Paris
UW Libraries
SJSU King Library
SJSU King Library
NUS Library
McGill
DET KGL BIBLiOTEK
JCU Discovery
Universidad De Lima
WorldCat
VU on WorldCat
PTZ: We're glad you're here. Please click "create a new query" if you are a new visitor to our website and need further information from us.
If you are already a member of our network and need to keep track of any developments regarding a question you have already submitted, click "take me to my Query."