Open Access Case Report Article ID: RAOA-1-104

    Laryngeal Primary Amyloidosis: Differential Diagnosis of Localized Granulomatosis with Polyangiitis. Report of Two Cases

    Clarissa de Queiroz Pimentel, Luciana Depiere Lanzarin, Frederico Adão de Oliveira Santana, Rosa Maria Rodrigues Pereira, Maurício Levy-Neto and Samuel Katsuyuki Shinjo*

    Primary laryngeal amyloidosis (PLA) and granulomatosis with polyangiitis (GPA) can present rarely with the isolated symptom of dyspnea and/or dysphonia, affecting exclusively the larynx.

    Granulomatosis with polyangiitis is one of the anti-neutrophil cytoplasmatic antibodies (ANCA) associated vasculitis. It may be limited to the airways including may be exclusively laryngeal. This localized form of GPA has a diffi cult diagnosis because the biopsy rarely does the diagnosis and the ANCA tests are frequently negative.

    In the aim of emphasizing the importance of this rare entity as a differential diag

    Keywords: Amyloidosis; Dysphonia; Dyspnea; Granulomatosis withpolyangiitis; Larynx.

    Published on: Mar 8, 2017 Pages: 17-19

    Full Text PDF Full Text HTML DOI: 10.17352/raoa.000004
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