Primary laryngeal amyloidosis (PLA) and granulomatosis with polyangiitis (GPA) can present rarely with the isolated symptom of dyspnea and/or dysphonia, affecting exclusively the larynx.
Granulomatosis with polyangiitis is one of the anti-neutrophil cytoplasmatic antibodies (ANCA) associated vasculitis. It may be limited to the airways including may be exclusively laryngeal. This localized form of GPA has a diffi cult diagnosis because the biopsy rarely does the diagnosis and the ANCA tests are frequently negative.
In the aim of emphasizing the importance of this rare entity as a differential diag
Keywords: Amyloidosis; Dysphonia; Dyspnea; Granulomatosis withpolyangiitis; Larynx.
Published on: Mar 8, 2017 Pages: 17-19
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DOI: 10.17352/raoa.000004
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