Study of the µ opioid receptor in cutaneous ulcers of leishmaniasis and sporotrichosis according to the complaints of local pain

Patrícia Elizabeth Pignataro*, Leonardo Pereira Quintella, Luiz Cláudio Ferreira, Francisco das Chagas de Carvalho Rodrigues, Liliane de Fátima Antonio Oliveira, Marcelo Rosandiski Lyra and Maria Inês Fernandes Pimentel

Patients with cutaneous leishmaniasis or sporotrichosis with ulcerated lesions may present similar epidemiological and clinical characteristics. Local pain is often referred to in the sporotrichosis lesions, but not in cutaneous leishmaniasis. The µ Opioid Receptor (MOR) is indirectly associated to the production of cytokines, and is related to the epidermal proliferation. The aim of this study was to evaluate MOR expression and the histopathological changes in cutaneous lesions of sporotrichosis and leishmaniasis, and its association with complaints of local pain. Thirty-eight outpatients with sporotrichosis (19), leishmaniasis (14) and unspecific ulcers (5) treated at Rio de Janeiro, Brazil, were submitted to histological and immunohistochemically analysis for MOR according to the complaints of local pain. No association was found among the expression of MOR; the cutaneous histopathological changes of cellular composition of the inflammatory infiltrate tissue, of keratinocyte, of endothelial cells and of nerves; and the presence or absence of local pain in the cutaneous lesions of leishmaniasis, sporotrichosis or unspecific ulcers. A plausible explanation is that nociception is regulated by neurons of the dorsal root ganglion or by descending modulation through noradrenergic inhibitory neurons from central nervous system.

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Published on: Dec 31, 2019 Pages: 7-13

Full Text PDF Full Text HTML DOI: 10.17352/ojtm.000009
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