Abstract

    Open Access Research Article Article ID: OJPP-7-120

    To evaluate the anti-diabetic effects of Salvia cabulica ethanolic extract on alloxan-induced diabetic rabbits

    Abdul Ghaffar, Marvi, Mohammad Younis, Abdul Wahid*, Shafi Muhammad and Faisal Ahmed

    Objective: This study aimed to investigate the hypoglycemic effects of Salvia cabulica ethanolic extract on alloxan-induced diabetic rabbits. 

    Method: During the plant’s extraction, the dried plant was soaked in ethanol for 14 days at room temperature and filtered. The dark green gummy filtrate was obtained by using a rotary evaporator at 40oC. Rabbits with fasting glucose levels of more than 250 mg/dL were considered diabetic. These rabbits were treated with aqueous plant extract in different doses (250 mg and 500 mg) respectively. 

    Results: The fasting blood glucose level (BGL) mean was 293 ± 25.65 in diabetic control group D-I compared to the normal control group A 99 ± 6.16 after the 48 hours of diabetes induction. The fasting blood glucose level (BGL) in group D-II was 192 ± 17.06, group D-III 93.515.95and group D-IV was 89.33 ± 7.79. 

    There was a significant decrease in blood glucose among the group III and IV treated with plant extract at 250 mg/kg and 500 mg/kg, respectively

    Conclusion: The plant Salvia cabulica has potential hypoglycemic activity. Therefore, the medicinal plant can be used as a folklore herbal drug in the treatment of diabetes locally.

    Keywords:

    Published on: Jul 19, 2022 Pages: 7-12

    Full Text PDF Full Text HTML DOI: 10.17352/ojpp.000020
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