Liposomes, sphere-shaped vesicles consisting of one or more phospholipid bilayers, were fi rst
described in the mid-60s. Nowadays, they are a very useful reproduction, reagent, and device in various
scientifi c disciplines, including medicine, chemistry, biochemistry, colloid science, biology, physics,
biophysics, mathematics and theoretical. After the initial discoveries liposomes have made their way to
the market. Among numerous brilliant new drug delivery systems developed, liposomes characterize an
advanced technology to deliver active molecules to the site of action, and at present, several formulations
are in clinical use. Research on liposome technology has progressed from conventional vesicles to
‘second-generation liposomes’, in which long-circulating liposomes are obtained by modulating the lipid
composition, size, and charge of the vesicle. Liposomes with modifi ed surfaces have also been developed
using several molecules, such as glycolipids or sialic acid. This paper mini review summarizes exclusively
Nano-lipids, its applications in medicine scalable techniques in treating dreadful diseases cancer, AIDS,
paralysis etcand focuses on strengths, respectively, limitations in respect to industrial applicability and
regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.
Keywords: Liposome; Drug delivery; Methods; Cell; Carriers
Published on: Oct 26, 2018 Pages: 5-21
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DOI: 10.17352/ojpp.000007
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