Open Access Review Article Article ID: OJPG-3-105

    Serum Pharmacochemistry in Herbal Medicine and Its Active Ingredients: Current Evidence and Future Development

    Kai Zhou, Ai-hua Zhang, Jian-hua Miao, Hui Sun, Guang-li Yan, Fang-fang Wu and Xi-jun Wang*

    Traditional Chinese medicine (TCM) is more and more increasingly concerned all over the world based on its multiple ingredients, multi-target, effectiveness and hypotonicity. However, the fuzzy cognition of the effective ingredients of TCM has been the fundamental reason that hinders its development due to complexity and uncertainty.

    For the sake of modernization of TCM, discovering the effective ingredients of Herb Medicine (HM) or TCM formulae as the markers of the inner quality control is urgent now. Luckily, the new technologies and methods are more applied for discovering the active constituents of HM or TCM formulae. In the context of the effective ingredients which are absorbed into blood, the method of serum pharmacochemistry of TCM (SPT) has been considered as a rapidly and effective tool to investigate the effective constituents. Therefore, one of the purposes of the review is to make it easier to understand and apply the theory of SPT by meaning of briefly introducing some strategies, key technologies and recently applications. Secondly, it is necessary for SPT to integrate with metabolomics based on its inherent disadvantages, in addition, network analysis and Q-Marker will be referred as the new directions to better develop SPT, it is not only for comprehensive control of quality of HM and TCM formulae, but also for the modernization and internationalization of TCM.


    Published on: Dec 31, 2018 Pages: 1-10

    Full Text PDF Full Text HTML DOI: 10.17352/ojpg.000005
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