Potential of Imiquimod and Fulvestrant against Mycobacterium tuberculosis using Molecular docking approach

Asma Noor*, Muhammad Imran Qadir, Ardas Masood, Jawaria Khan and Sania Ahmad

Mycobacterium Tuberculosis cause severe disease of lungs known as Tuberculosis. It is a major cause of morbidity and mortality even in the emerging countries also. However, to prepare an antibiotics drug against Mycobacterium tuberculosis is a major challenge. Two compounds Imiquimod, Fulvestrant were selected for our study which can stop action of Arbinosyl transferase enzyme of M.tuberculosis. In silico docking was carried out by using software named swissdock (http://www.swissdock.ch/). These are computer aided drug designing techniques which are helpful for this study. Both the above 2 drugs have the potential to block the activity of mutant strain of M.tuberculosis.

Keywords: Mycobacterium tuberculosis; Imiquimod; Fulvestrant

Published on: Jul 28, 2017 Pages: 23-25

Full Text PDF Full Text HTML DOI: 10.17352/ojc.000008
CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat