Mild depolarization of the inner mitochondrial membrane is a crucial component of the mechano-chemiosmotic mechanism of coupling

Eldar A. Kasumov*, Ruslan E. Kasumov and Irina V. Kasumova

The human body receives the main energy in the form of ATP (about 50 kg per day), mainly by oxidative phosphorylation in the mitochondria, and a small part from glycolysis. It has been recognized a long ago that several major human diseases (2 type diabetes, cancer, heart diseases, etc.), and aging are associated with mitochondrial dysfunction. Mitochondrial dysfunction causes a dramatic fall of ATP production and an increase in ROS production.

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Published on: Jun 20, 2020 Pages: 33-35

Full Text PDF Full Text HTML DOI: 10.17352/2455-5487.000075
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