Objective: To investigate the short and long-term outcomes of a concurrent exercise protocol
(CEP) on plasma Brain-derived neurotrophic factor (BDNF) levels and the effect of this intervention in
the self-esteem and mental health in people with schizophrenia (SZ).
Methods: In this quasi-experimental study, 15 participants underwent a structured, supervised
and group based CEP for 12 weeks (the sessions were performed 3 times a week for 60 minutes). In
order to verify the short- and long-term effects of exercise on BDNF levels, blood samples of 15 ml were
collected pre-intervention and on the 4th, 8th and 12th week(s) after intervention started. To evaluate
self-esteem, the Rosemberg Self-esteem Scale was used, and the general mental health status was
measured through the General Health Questionnaire-12 (GHQ-12). Both questionnaires were applied
before and after intervention.
Results: BDNF plasma levels increased signifi cantly at the 12 th week(s) when compared to
baseline and in 4 weeks periods. There were no observed changes on self-esteem neither a trend of
improvement in the GHQ at the post-intervention phase when compared to the baseline. Finally, the
CEP reduced signifi cantly anthropometric variables.
Conclusion: The CEP induced time-dependent modulation on BDNF levels in individuals with SZ,
increasing its levels only in a long-term period.
Keywords:
Published on: Jan 18, 2018 Pages: 1-6
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DOI: 10.17352/2455-5487.000056
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