The wide use of microbicide is mainly depends on its effectiveness, less frequent application,
ready availability and most importantly cost. The aim of this work was to develop affordable microbicide
mucoadhesive gel formulation of synthetic anti HIV drug, stavudine and to characterise it in terms
of its physical properties, mucoadhesiveness and spreadability. The purpose of the present study
was also to compare different dissolution media used for in vitro release of vaginal dosage form. The
gels were tested for antimicrobial, spermicidal and anti-HIV activity. Gels prepared using Carbopols
and Polycarbophil were transparent and homogenous and had excellent mucoadhesion index - and
showed fast drug release profile. Gels showed very good antimicrobial action against pathological
microorganism.
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Published on: Dec 18, 2014 Pages: 27-33
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DOI: 10.17352/2455-3786.000006
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