Different roles of sex hormones in inflammation may lead to sex-disaggregation of COVID-19 pathology

Hua Li, Tengfei Zhang* and Chaofeng Han*

Severe acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2), the single strain RNA virus, infection causes the global pandemic coronavirus disease 2019 (COVID‐19), in which the immune escape ability of SARS‐CoV‐2 has an important role by inhibiting antiviral innate immunity. Pattern-Recognition Receptors (PRRs), such as Retinoic acid-Inducible Gene I (RIG-I), induce antiviral innate immune responses by sensing viral nucleotides and producing type I interferons. Epidemiological investigation reveals there is sex disaggregation in that males experience more severe symptoms and suffer higher mortality from COVID‐19 than females. This review discusses the different roles of sex hormones in the immune response to SARS‐CoV‐2 infection to explain the mechanism of sex disaggregation and explore novel preventive strategies.

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Published on: Jan 6, 2023 Pages: 1-2

Full Text PDF Full Text HTML DOI: 10.17352/jgro.000118
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