Open Access Case Report Article ID: JCRO-8-190

    Fresh frozen plasma as a source of plasminogen for ligneous conjunctivitis: Case report and a review of the literature

    Benjamin J Park, David Camoriano, Mark C Vital, Patricia Chévez-Barrios, John D Goosey and Marcel Belloso*

    Purpose: To describe management of a patient with ligneous conjunctivitis secondary to plasminogen deficiency and review the literature on treatment with plasminogen.

    Design: Interventional case report.

    Methods: A 6-year-old Caucasian girl developed ligneous conjunctivitis recalcitrant to debridement and treatment with topical cyclosporin A and steroids. The literature was reviewed regarding treatment of ligneous conjunctivitis with plasminogen.

    Results: The patient was treated with plasminogen containing drops derived from her father’s fresh frozen plasma. The ligneous conjunctivitis resolved, and the patient was managed on these drops for the following 8 years, initiating treatment for flares and tapering according to clinical response.

    Conclusions: Plasminogen drops concentrated from fresh frozen plasma are a safe and effective option for long-term treatment of ligneous conjunctivitis.


    Published on: Jul 19, 2021 Pages: 31-35

    Full Text PDF Full Text HTML DOI: 10.17352/2455-1414.000090
    CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat


    Global Views

    Case Reports

    Peertechz Tweets

    Pinterest on JCRO

    Help ? Google Reviews 11