Crosstalk between oxidative stress and ocular diseases

Lizette Gil del Valle*, Mirtha Copello Noblet and Gregorio Martínez-Sanchez

Context: Diverse findings reported during the past years has established the molecular mechanisms by which a disparity in the redox balance system in microenvironment and cells with high grade of Oxidative Stress (OS) can cause oxidation of macromolecules as nucleic acids, lipids, proteins and carbohydrates, thus bringing about their function alteration. These events also result in modulation of redox circuits herein signal transduction pathways and activation of transcription factors that can lead to chronic inflammation and contribute to several chronic diseases, including eye diseases and retinopathy.

Aims: The article proposes a review of the knowledge about OS pathways in eye’s diseases.

Methods: The search was carried in the LILACS, PAHO, SciELO, EMBASE, PubMed and Infomed databases, Google search engines and Google Scholar where the key words were placed to obtain information from original articles, theses, other articles of bibliographic review and high citation index journals published from 1980 to 2019, in Spanish or English.

Results: Four hundred seventy documents were identified, of which 91 were selected. The most important oxidant and reactive oxygen species produced by various physiological pathways, chemical and biological factors, including genetic and pathological conditions have been revised.

Conclusions: This document summarizes the evidences of crosstalk between OS and ocular diseases, including retinitis pigmentosa.

Keywords:

Published on: Jun 17, 2020 Pages: 37-47

Full Text PDF Full Text HTML DOI: 10.17352/2455-1414.000071
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