Open Access Short Communication Article ID: JCMC-9-286

    In Silico modeling of immune-cardiovascular-endocrine interactions

    Kristen A Windoloski, Johnny T Ottesen and Mette S Olufsen*

    The immune system provides an intricate, balanced response to combat the effects of inflammatory stimuli. It incorporates both positive and negative feedback from multiple physiological systems such as the cardiovascular and endocrine systems including mechanisms functioning on a variety of time scales. They have been studied individually via scientific experiments and using mathematical modeling. However, more analysis is needed to study the interactions between these three systems during an inflammatory event. We present the first dynamical systems model studying immune, cardiovascular and endocrine responses to a 2 ng/kg bolus dose of endotoxin. The model is calibrated to experimental data from two endotoxin challenge studies and we use this model to investigate the effects of endotoxin dosage, administration timing and administration method. Our model shows that most repercussions of endotoxin administration clear the system within 24 hours, but effects can linger for up to 72 hours.


    Published on: Oct 15, 2022 Pages: 37-41

    Full Text PDF Full Text HTML DOI: 10.17352/2455-2976.000186
    CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat


    Global Views

    Case Reports

    Peertechz Tweets

    Pinterest on JCMC

    Help ? Google Reviews 11