An Updated Systematic Review and Meta-analysis of the Short- and Long-term Outcomes of Percutaneous Coronary Intervention for Patients with Severe Left Ventricular Systolic Dysfunction

Nuremanguli Abudukeremu§, Zi- Xiang Yu1§, Yi-Ning Yang, Siew- Pang Chan, Xiao-Mei Li, Fen Liu, Yi-Tong Ma*

Background: Coronary artery disease (CAD) is the most common cause of left ventricular dysfunction

(LVD). Confl icting evidence exists with regards to available treatments and patient prognosis.

Revascularization may improve ventricular function while coronary artery bypass surgery (CABG) has

signifi cantly improved survival. The effectiveness of percutaneous coronary intervention (PCI) has also

not been thoroughly investigated to date.

Objectives: To ascertain the in-hospital and long-term (≥1 year) outcomes of CAD patients with LV

systolic dysfunction (ejection fraction ≤40%) after PCI according to a meta-analysis.

Methods: A systematic literature search and a series of random-effect meta-analyses were conducted to evaluate the short- and long-term outcomes of PCI of the selected studies. Single-center studies andthose that did not report evidence on long-term mortality were excluded in the analysis. All statistical tests were performed with 95% confi dence intervals. A p-value of less than 0.05 was considered statistically significant.

Keywords: Coronary artery disease; Left ventricular dysfunction; Percutaneous coronary intervention; Mortality

Published on: Nov 6, 2018 Pages: 73-80

Full Text PDF Full Text HTML DOI: 10.17352/2455-2976.000076
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