Open Access Review Article Article ID: JCMC-5-174

    Nature of Human Gut Microbiome: How do they play in Cardiovascular Disease?

    Han Naung Tun*

    Cardiovascular disease is the number one killer of death around the world. Most of the cardiovascular

    diseases are caused by sedentary life style, bad eating habit, tobacco smoking, high alcohol intake,

    dyslipidemia and genetic factors .Recently the idea of human microbiome science has emerged

    in diseases pathogenesis .The human gut is a house of trillions of microbial fl oral. Since a couple of

    decades ago, there has been interesting insights into the human gut microbiota and have highlighted

    its increasingly association to cardiovascular (CV) and metabolic diseases. Trimethylamine N-oxide

    (TMAO), which is a metabolic product from gut microbiota plays a central role in cardiovascular disease

    pathogenesis. Nature of microbial inhabitants within the host has been noticed by the numbers of

    scientists and researchers to understand more about the hidden mechanism of diseases pathogenesis

    including cardiovascular disease, metabolic and autoimmune diseases and it has become a good hope to

    develop new drug designs to prevent metabolic and cardiovascular disease in near future.

    Keywords: Cardiovascular disease; Metabolic; Gut bacteria; TMAO; Microbiome

    Published on: Nov 5, 2018 Pages: 64-66

    Full Text PDF Full Text HTML DOI: 10.17352/2455-2976.000074
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