Histomorphological characterization of Moringa- oleifera oil and walnut oil on cadmium induced lateral geniculate body damage in adult wistar rats (Rattus novergiccus)

Omotoso OD, Adelakun SA*, Idomeh IJ and Ogbonna E

Background: Cadmium (Cd) has been reported to cause distinct neurotoxic effects in adult and newborn animals. This study was designed to investigate some of the effects caused by cadmium on the lateral geniculate body of adult male wistar rats and the ameliorative properties of antioxidants present in Moringa oleifera seed oil and walnut oil extracts. 

Methods: Seven groups of five animals each were used in this experiment. Group A received 3 ml of 0.9% normal saline; group B received 2.5 mg/kg bw of 3CdSO4.8H2O, group C received 5 mg/kg bw vitamin C & 6 mg/kg bw vitamin  E, group D received 5 mg/kg bw vitamin C & 6cmg/kg bw vitamin E + 2.5mg/kg bw Cd, group E received 2.5 mg/kg bw Cd + 4 mg/kg bw Moringa oleifera Oil, group F received 2.5 mg/kg bw Cd + 4 mg/kg bw walnut oil, while group G received 2.5 mg/kg bw Cd + 2 mg/kg bw walnut + 2 mg/kg bw Moringa oleifera oil concomitantly for 3 weeks, histomorphological investigations were carried out in the brain tissues. 

Results: Light microscopy examination revealed marked changes in the structure of the studied tissues of Cd administered animals. However, administration of vitamin C & E, walnut and Moringa oleifera seed oil was seen to counteract the changes of the measured parameters and restore the damaged tissues associated with Cd administration to appear nearly like those of the control group A.

Conclusion: Walnut and Moringa oleifera seed oil administration attenuated morphological changes induced by cadmium in the lateral geniculate body of the brain of the adult male wistar rats.

Keywords: Lateral geniculate body; Histomorphological; Cadmium; Oxidative damage

Published on: Jan 4, 2019 Pages: 1-7

Full Text PDF Full Text HTML DOI: 10.17352/jbm.000005
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