In-silico analysis of tenidap and its derivative as a novel 5-lipoxygenase inhibitor

Asma Noor*, Ardas Masood, Jawaria Khan, Tanveer Abbas and Muhammad Imran Qadir

Tenidap is a derivative of Flavonoids which are actually plant derivatives, it shows inhibition activity

of 5-lipoxygenase. Molecular models were directed to discover molecular docking mode, also to help

explain molecular tool behind its inhibitory action. Molecular relations of tenidap with the catalytic trio

(His523, His518, Ile875) inside active or dynamic position of 5-lipoxygenase through hydrogen bonding,

appears to the major reason elaborate in its substantial 5-lipoxygenase activity of inhibition.

Keywords: Tenidap; 5-lipoxygenase; Anti-inflammatory effect

Published on: Nov 24, 2017 Pages: 36-38

Full Text PDF Full Text HTML DOI: 10.17352/ijpsdr.000015
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