Protective Effect of Alkaloids from Amaranthus Viridis Linn. Against Hydrogen Peroxide Induced Oxidative Damage in Human Erythrocytes (RBC)

Vadivukkarasi Sasikumar*, Arunambiga Subramaniam, Anila Aneesh, Ganapathy Saravanan

Plants are rich in antioxidants which play an essential role in disease prevention. maranthus viridis linn. Is a common medicinal plant, spread throughout the world is used in traditional yurvedic medicine. The present study was aimed to examine the protective effect of partially purified alkaloids (PPA) from Amaranthus viridis against hydrogen peroxide induced oxidative damage in human erythrocytes in vitro conditons. The experiments are performed in groups (Control, H2O2 induced and H2O2 + 25, 50 mg conc of alkaloids). The enzymic antioxidants like CAT, SOD, GPx, GST and non enzymic antioxidants like vitamin C, vitamin E and GSH levels and LPO were evaluated to determine the protective effect of alkaloids. The alkaloids prevent the decline of antioxidant status which in turn decreases LPO levels by preventing MDA formation in erythrocytes. The results confirm the protective effect of  lkaloids against free radical induced oxidative damage in human erythrocytes.

Keywords: Antioxidants; Amaranthus; Erythrocytes; Antihaemolytic activity; Alkaloid; hydrogen peroxide

Published on: Dec 9, 2015 Pages: 49-53

Full Text PDF Full Text HTML DOI: 10.17352/ijcem.000011
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