Natural bee bread positively regulates lipid metabolism in rats

Zhen Li, Qiang Huang, Yibo Liu, Chengtao Peng and Zhijiang Zeng*

Natural bee bread contains various active ingredients, which can promote human health. However, the functional evaluation of bee bread is seldom reported. We conducted this study to evaluate the effect of natural bee bread on lipid metabolism using rats as model organism. 

Rats were treated with three doses of bee bread (80 mg/kg, 400 mg/kg and 800 mg/kg). A blank control group and a high fat model control group also were set up. The protein and gene expression of Fatty Acid Synthase (FAS), Acetyl CoA carboxylase (ACC) and lipoprotein lipase (LPL) in the liver tissue of rats were measured by reagent kits and real time quantitative PCR (RT-qPCR), respectively. The results showed that bee bread treatment groups significantly decreased the concentration of FAS and ACC in the liver (P<0.05). LPL was also reduced after bee bread treatment, even though the difference was not statistically significant from the high fat model group. The gene expression levels of FAS and ACC significantly declined (P<0.05) in all treatment groups compared with the high fat model group. It was concluded that the natural bee bread has a positive effect on the regulation of rat lipid metabolism, indicating that it is a promising lipid metabolic regulator candidate to treat hyperlipidemia.

Practical applications: Our results show that it is a promising lipid metabolism regulator, and may be used to treat hyperlipidemia. 

Keywords:

Published on: Sep 4, 2021 Pages: 266-271

Full Text PDF Full Text HTML DOI: 10.17352/2455-815X.000118
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