Meta-analysis of the epidemiology of microvascular complications in people with Type 2 diabetes in mainland China

Yuanyuan CHENG, Shuli QU, Yanjun LIU, Yuqi ZHANG, Wenjie XU, Li CHEN*

Objective:  This study aims to estimate the overall prevalence of microvascular complications of type 2 diabetes in mainland China, and to identify any associated risk factors. 

Methods: A systematic literature search was conducted to collect the prevalence information of microvascular complications over the past 5 years (2014 -2019) in CNKI, Wanfang, PubMed and the Cochrane Library. A meta-analysis was conducted using R3.4.3 following normal transformations given the skewed raw data. Due to high heterogeneity, a random effect model was selected. A meta-regression analysis was performed to investigate risk factors. 

Results: A total of 171 studies were included in the meta-analysis. Of which, 86 studies in diabetic retinopathy, 61 in diabetic nephropathy and 24 in diabetic foot. Results of the meta-analysis showed that the prevalence of diabetic retinopathy was 26.19% [95% CI: 23.02%-29.50%], diabetic nephropathy 27.09% [95% CI: 23.55%-30.79%], and diabetic foot 7.41% [95% CI.5.48%-10.03%], respectively. Duration of type 2 diabetes was identified as the risk factor which was significantly associated with the prevalence of all three microvascular complications (p<0.05).

Conclusion: In mainland China, the prevalence of microvascular complications in patients with type 2 diabetes is high. Early diagnosis and treatment of type 2 diabetes may prevent or delay the development of microvascular complications.

Keywords:

Published on: Jun 5, 2020 Pages: 18-23

Full Text PDF Full Text HTML DOI: 10.17352/2455-8583.000042
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