Introduction: Catalase decomposes hydrogen peroxide into oxygen and water. Its low concentration could be involved in signaling while its high concentration is toxic.
Aim: This short review discusses the association of blood catalase and diabetes mellitus in Hungarian diabetic patients.
Results: Several cohort studies showed decreased blood catalase activity in type 2 diabetes and in gestational diabetes.
Among the catalase gene polymorphisms rs769217 showed a weak association with type 1 diabetes. Regarding rs1001179 polymorphism patients with TT genotype have a risk for lower life expectancy.
In acatalasemics the frequency of diabetes mellitus is higher (P˂0.001) than in the Hungarian population. 11 of 12 known Hungarian acatalasemia mutations are found in diabetic patients. Acatalasemia may be associated with a higher risk for diabetes mellitus especially for its type 2 form.
Acatalasemia mutations could explain the decreased (˂50%) blood catalase activities only in 17.4% of the cases.
Conclusions: Blood catalase activity is decreased in type 2 and gestional diabetes. Patients with inherited catalase deficiency and known acatalasemia mutation are at higher risk of diabetes mellitus.
The lifelong effect of oxidative damage on the oxidant sensitive, insulin producing pancreatic beta-cells could contribute to the manifestation of diabetes mellitus especially to type 2 form.
Acatalasemia mutations could explain the reason for the catalase decrease while for the other (82.6 %) cases it remains unsolved.
The decreased blood catalase activity in type 2 and gestational diabetes rather due to regulatory mechanisms than to the catalase gene mutations.
Keywords: Catalase enzyme; Blood catalase; Catalase gene polymorphisms; Acatalasemia; Diabetes mellitus
Published on: Mar 21, 2016 Pages: 1-5
Full Text PDF
Full Text HTML
CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat
Ohio State University, USA
Open Journal of Bioinformatics and Biostatistics
Leeds Beckett University, UK
Archives of Community Medicine and Public Health
Wei Min HUANG
Nanyang Technological University, Singapore
Archive of Biomedical Science and Engineering
Metaxas Memorial Anticancer Hospital , Greece
Annals of Bone Marrow Research
Catholic University of Lyon, France
Annals of Cytology and Pathology
Vingolo Enzo Maria
Sapienza University of Rome, Italy
Journal of Clinical Research and Ophthalmology
University of Genoa, Italy
Global Journal of Allergy
Former member of MGH, USA
International Journal of Immunotherapy and Cancer Research
Rafal Tomasz Pawliczak
Medical University of Lodz, Poland
Open Journal of Asthma
University of Parma, Italy
International Journal of Dermatology and Clinical Research