Background: One hundred once patients underwent heart transplants due to multiple causes. These patients included 36 females and 65 males whose mean age was 51 years.
Objective: To study metabolic and lipid changes after heart transplantation with emphasis on HDL in rejected and non rejected hearts.
Methods: The metabolic changes pre and post transplant were analyzed.
1. Body mass index (BMI): 25 ± 4 - 28 ± 5 kg/ m2 (P<0.05)
2. Systolic blood pressure (sBP): 107 ± 17 - 131 ± 20mmHg (P<0.05)
3. Diastolic blood pressure (dBP): 70 ± 13 - 81 ± 10 mmHg(P<0.05)
4. Fasting blood sugar (FBS): 107 ± 37- 117 ± 55 mg%(0.164) (non significant)
5. Cholesterol: 170 ± 55 - 189 ± 32 mg/dl(P<0.05)
6. High density lipoprotein (HDL): 38 ± 16 - 52 ± 17 mg/dl (P<0.05)
7. Low density lipoprotein (LDL): 99 ± 20- 83 ± 15 mg/dl (0.34).
8. Triglycerides: 163 ± 10 -188 ± 12 mg/dl (0.144).
Conclusions: The heart transplant patients developed metabolic syndrome (MetS). The elevated HDL levels observed after transplantation are indicative of role of immunologic reaction to chronic rejection processes. The patients who died of rejection (19) exhibited greater elevations in HDL that those who did not (47 ± 22 – 71 ± 40 mg/dl, P<0.05). Seven autopsies were performed and revealed severe atherosclerotic changes in the aorta and coronary arteries that were likely related to dysfunctional HDL. The transplanted hearts were 21 years old. The high levels and persistent elevation of HDL observed in the rejected group can be used as a biomarker of rejection and this will help to change the anti-rejection protocol to try to avoid the rejection of the implanted heart. LDL was found to be a factor in the progressive atherosclerotic process because the level was reduced post transplant.
Keywords: Metabolic syndrome; Heart transplant; HDL; Rejection
Published on: Sep 20, 2014 Pages: 1-6
Full Text PDF
Full Text HTML
CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat
Sassari University, Italy
Archive of Urological Research
Marco Matteo Ciccone
University of Bari , Italy
Archives of Organ Transplantation
Hon. Pierre Guertin
Laval University, Canada
Global Journal of Obesity, Diabetes and Metabolic Syndrome
Catholic University of Lyon, France
Annals of Cytology and Pathology
Ohio State University, USA
Open Journal of Bioinformatics and Biostatistics
Beijing University of Technology , PR China
Journal of Civil Engineering and Environmental Sciences
University of Padua, Italy
Journal of Gynecological Research and Obstetrics
Democritus University of Thrace , Greece
International Journal of Vascular Surgery and Medicine
Columbia University, USA
Journal of Novel Physiotherapy and Physical Rehabilitation
University of Genoa, Italy
Global Journal of Allergy