Clinical study on blood routine and dynamic changes, condition and prognosis of hand foot and mouth disease (EV71)

Ling-liang Yao* and Le Kang

Objective: To explore the relationship between the total number of white blood cells and the ratio of neutrophils to lymphocytes in the blood of hand-foot-mouth disease (EV71) and the condition of the disease, and to explore the relationship between the dynamic changes of blood samples above the early severe cases and the trend of prognosis. 

Methods: 216 outpatient and hospitalized cases according to the condition can be divided into: (I group) in critical group of 17 cases, (II group) early intensive group 167 cases, 32 cases (III group) ordinary group. Age, course of disease, total number of white blood cells and neutrophil ratio were compared. According to the dynamic changes of the above blood images, the patients in the early severe group were further divided into: group A, 49 patients in the group with increased ratio of white blood cells and neutrophils. In group B, the ratio of leukocyte to lymphocyte was increased in 53 patients. In group C, there were 67 cases of leukocyte decrease and lymphocyte ratio increase. 

Results: (1) statistical analysis of various indicators including age, course of disease, total number of white blood cells and neutrophil ratio of patients with different disease conditions: there was no statistically significant difference in disease course between the groups (F=1.38 P>0.05), while there were statistically significant differences among the groups in age, total number of white blood cells and neutrophil ratio (F value: 4.9, 14.15, 25.98, respectively). P < 0.01). (2) in group A, 4 of the 49 cases developed into critically ill patients, and the conversion rate of critically ill patients was 8.16%; in group B and group C, the conversion rate of critically ill patients was 0; in group A, the conversion rate of critically ill patients was statistically significant compared with the other two groups (P<0.01). 

Conclusion: HFMD (EV71) is related to the total number of white blood cells and the ratio of neutrophils. The changes of the dynamic ratio of leukocytes and neutrophils to lymphocytes have clinical significance for the trend of prognosis.

Keywords:

Published on: Apr 20, 2021 Pages: 33-36

Full Text PDF Full Text HTML DOI: 10.17352/2455-5363.000043
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