Abstract

    Open Access Research Article Article ID: GJCT-8-146

    A first comprehensive look at the order-disorder nature of RTK KIT native and carcinogenic targets

    Luba Tchertanov* and Julie Ledoux

    Receptors Tyrosine Kinases (RTKs) act as sensors for extracellular ligands, the binding of which triggers dimerization, activation, and autophosphorylation of specific tyrosine (Y) residues in the Cytoplasmic Domain (CD). This leads to the recruitment and activation of multiple downstream signaling proteins, which regulate various aspects of cellular physiology. 


    Keywords:

    Published on: Oct 7, 2022 Pages: 36-39

    Full Text PDF Full Text HTML DOI: 10.17352/2581-5407.000046
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