Open Access Research Article Article ID: GJCT-7-138

    Essentially new inhibitors of metastasis of malignant tumors for chemotherapy-sparing treatment

    ISh Nadiradze* and NSh Chigogidze

    The purpose of this work was

    1. Processing a new concept of specific inhibitors for metastasis to mercy cancer chemotherapy for oncology.

    2. A chemical synthesis of Multinucleated Anion active Metastasis inhibitors based on processed conception.

    3. Trial them in D60p4 cell line culture of atypical fibroblasts of different concentrations.

    Georgia has received a patent for the first medicine (Amphicezine) of this class, which does not damage the normal healthy cells in the body. There are presented the synthesis schemes and methods of prospective metastasis inhibitors by the authors. The second-generation works of Multinucleated Anion active Metastasis inhibitors have been completed, there is also discussed and shown multifunctional action on tumor cells, connections between oncodrugs activity and their ligand properties.


    Published on: Feb 24, 2021 Pages: 16-30

    Full Text PDF Full Text HTML DOI: 10.17352/2581-5407.000038
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