MicroRNAs in Oncology

Yusuf Tutar*

MicroRNAs (miRNAs) are a family of short non-coding RNA molecules which contain about 18-24 nucleotides.miRNAs play significant regulatory roles in biological processes (cell proliferation, differentiation,survival and motility). miRNAs are essential regulators of coding genes at the post-transcriptional level.The biogenesis of miRNAs is composed of complex processes, and human genome contains approximately two thousand miRNAs (http://www.mirbase.org) [1,2]. Expression patterns of miRNAs have been found to have links with pathogenesis of many diseases including neurodegenerative diseases, diabetes, cardiovascular diseases,and particularly cancer.miRNAs have been identified as a critical biomarker for treatment, diagnosis, and progression of cancer.Experimental and computational data indicates that miRNAs are up-regulated or down-regulated in cancer cells, and therefore, they
have oncogenic (oncomirs) or tumor-suppressive roles in apoptosis,angiogenesis, proliferation, metastasis, and differentiation in cancer cells [

Keywords:

Published on: Jul 6, 2015 Pages: 9-9

Full Text PDF Full Text HTML DOI: 10.17352/gjbbs.000003
CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat