Abstract

    Open Access Research Article Article ID: GJA-6-145

    Comparison of dexamethasone, granisetron and haloperidol in prevention of postoperative nausea and vomiting following laparoscopic surgeries: A prospective, double-blinded study

    Shikha Sharma*, Gnanasekar N and Pranjali Kurhekar

    Background: Laparoscopic surgeries are most commonly performed surgeries. However, they are associated with increased incidences of postoperative nausea and vomiting. 

    Aim: We aimed to compare the effectiveness of dexamethasone, haloperidol, granisetron in prevention of postoperative nausea and vomiting following laparoscopic surgeries. 

    Methods: We conducted a randomized, double-blinded study including 90 patients both males and females undergoing laparoscopic surgeries in a tertiary hospital over 18 months. The subjects were randomized into three groups. Group I Dexamethasone 8mg, Group II Granisetron 2mg, Group III Haloperidol 1mg (n=30 each group). The study drugs were administered intravenously immediately after intubation. Patients were observed every 4th hourly till 24 hours for incidence of nausea, vomiting, pain and sedation. 

    Results: Incidence of vomiting was significantly less in dexamethasone group (p=0.047) as compared to granisetron and haloperidol and was statistically significant (p<0.047).There was no significant difference in the incidence of vomiting between other two groups. All other parameters were comparable in all the groups. 

    Conclusion: Dexamethasone in the dose of 8mg significantly reduces incidence of vomiting in laparoscopic surgeries than haloperidol and granisetron. 

    Trial Registry: Clinical Trial Registry of India 2018/03/018324

    Keywords:

    Published on: Mar 29, 2019 Pages: 2-5

    Full Text PDF Full Text HTML DOI: 10.17352/2455-3476.000045
    CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat

    Indexing/Archiving

    Global Views

    Case Reports

    Peertechz Tweets

    Pinterest on GJA

    Google Reviews 11